FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3017090987> ?p ?o ?g. }

• W3017090987 endingPage "e4528" @default.
• W3017090987 startingPage "e4528" @default.
• W3017090987 abstract "Fully understanding the chemicals in an herbal medicine remains a challenging task. Molecular networking (MN) allows to organize tandem mass spectrometry (MS/MS) data in complex samples by mass spectral similarity, which yet suffers from low coverage and accuracy of compound annotation due to the size limitation of available databases and differentiation obstacle of similar chemical scaffolds. In this work, an enhanced MN-based strategy named diagnostic fragmentation-assisted molecular networking coupled with in silico dereplication (DFMN-ISD) was introduced to overcome these obstacles: the rule-based fragmentation patterns provide insights into similar chemical scaffolds, the generated in silico candidates based on metabolic reactions expand the available natural product databases, and the in silico annotation method facilitates the further dereplication of candidates by computing their fragmentation trees. As a case, this approach was applied to globally profile the steroidal alkaloids in Fritillariae bulbus, a commonly used antitussive and expectorant herbal medicine. Consequently, a total of 325 steroidal alkaloids were discovered, including 106 cis-D/E-cevanines, 142 trans-D/E-cevanines, 29 jervines, 23 veratramines, and 25 verazines. And 10 of them were confirmed by available reference standards. Approximately 70% of the putative steroidal alkaloids have never been reported in previous publications, demonstrating the benefit of DFMN-ISD approach for the comprehensive characterization of chemicals in a complex plant organism." @default.
• W3017090987 created "2020-04-24" @default.
• W3017090987 creator A5004766943 @default.
• W3017090987 creator A5016394975 @default.
• W3017090987 creator A5025834518 @default.
• W3017090987 creator A5036436313 @default.
• W3017090987 creator A5073070877 @default.
• W3017090987 creator A5078663555 @default.
• W3017090987 creator A5086214987 @default.
• W3017090987 date "2020-06-19" @default.
• W3017090987 modified "2023-10-16" @default.
• W3017090987 title "Diagnostic fragmentation-assisted mass spectral networking coupled with in silico dereplication for deep annotation of steroidal alkaloids in medicinal Fritillariae Bulbus" @default.
• W3017090987 cites W1598925596 @default.
• W3017090987 cites W1980073604 @default.
• W3017090987 cites W1988997384 @default.
• W3017090987 cites W1989299822 @default.
• W3017090987 cites W1997591231 @default.
• W3017090987 cites W2005326953 @default.
• W3017090987 cites W2016346244 @default.
• W3017090987 cites W2049765837 @default.
• W3017090987 cites W2052331706 @default.
• W3017090987 cites W2070340546 @default.
• W3017090987 cites W2075033706 @default.
• W3017090987 cites W2077488126 @default.
• W3017090987 cites W2077979680 @default.
• W3017090987 cites W2079930144 @default.
• W3017090987 cites W2099983582 @default.
• W3017090987 cites W2101394823 @default.
• W3017090987 cites W2103745872 @default.
• W3017090987 cites W2105059634 @default.
• W3017090987 cites W2125636651 @default.
• W3017090987 cites W2150842057 @default.
• W3017090987 cites W2179948434 @default.
• W3017090987 cites W2283606770 @default.
• W3017090987 cites W2285468881 @default.
• W3017090987 cites W2291051953 @default.
• W3017090987 cites W2313909440 @default.
• W3017090987 cites W2344454748 @default.
• W3017090987 cites W2365285489 @default.
• W3017090987 cites W2473773485 @default.
• W3017090987 cites W2504691963 @default.
• W3017090987 cites W2555163954 @default.
• W3017090987 cites W2562488253 @default.
• W3017090987 cites W2588052175 @default.
• W3017090987 cites W2608236502 @default.
• W3017090987 cites W2611174581 @default.
• W3017090987 cites W2740619240 @default.
• W3017090987 cites W2900505235 @default.
• W3017090987 cites W2901787718 @default.
• W3017090987 cites W2922522932 @default.
• W3017090987 cites W2928460039 @default.
• W3017090987 cites W2939988707 @default.
• W3017090987 cites W2975464263 @default.
• W3017090987 cites W2980680496 @default.
• W3017090987 cites W2981175365 @default.
• W3017090987 doi "https://doi.org/10.1002/jms.4528" @default.
• W3017090987 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32559823" @default.
• W3017090987 hasPublicationYear "2020" @default.
• W3017090987 type Work @default.
• W3017090987 sameAs 3017090987 @default.
• W3017090987 citedByCount "10" @default.
• W3017090987 countsByYear W30170909872021 @default.
• W3017090987 countsByYear W30170909872022 @default.
• W3017090987 countsByYear W30170909872023 @default.
• W3017090987 crossrefType "journal-article" @default.
• W3017090987 hasAuthorship W3017090987A5004766943 @default.
• W3017090987 hasAuthorship W3017090987A5016394975 @default.
• W3017090987 hasAuthorship W3017090987A5025834518 @default.
• W3017090987 hasAuthorship W3017090987A5036436313 @default.
• W3017090987 hasAuthorship W3017090987A5073070877 @default.
• W3017090987 hasAuthorship W3017090987A5078663555 @default.
• W3017090987 hasAuthorship W3017090987A5086214987 @default.
• W3017090987 hasConcept C104317684 @default.
• W3017090987 hasConcept C111919701 @default.
• W3017090987 hasConcept C162356407 @default.
• W3017090987 hasConcept C185592680 @default.
• W3017090987 hasConcept C191015642 @default.
• W3017090987 hasConcept C2775905019 @default.
• W3017090987 hasConcept C2776321320 @default.
• W3017090987 hasConcept C31827203 @default.
• W3017090987 hasConcept C41008148 @default.
• W3017090987 hasConcept C43617362 @default.
• W3017090987 hasConcept C55493867 @default.
• W3017090987 hasConcept C60644358 @default.
• W3017090987 hasConcept C70721500 @default.
• W3017090987 hasConcept C86803240 @default.
• W3017090987 hasConceptScore W3017090987C104317684 @default.
• W3017090987 hasConceptScore W3017090987C111919701 @default.
• W3017090987 hasConceptScore W3017090987C162356407 @default.
• W3017090987 hasConceptScore W3017090987C185592680 @default.
• W3017090987 hasConceptScore W3017090987C191015642 @default.
• W3017090987 hasConceptScore W3017090987C2775905019 @default.
• W3017090987 hasConceptScore W3017090987C2776321320 @default.
• W3017090987 hasConceptScore W3017090987C31827203 @default.
• W3017090987 hasConceptScore W3017090987C41008148 @default.
• W3017090987 hasConceptScore W3017090987C43617362 @default.
• W3017090987 hasConceptScore W3017090987C55493867 @default.
• W3017090987 hasConceptScore W3017090987C60644358 @default.

• next