FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3017107596> ?p ?o ?g. }

• W3017107596 abstract "The neurochemical background of the evolution of headache disorders, still remains partially undiscovered. Accordingly, our aim was to further explore the neurochemical profile of Complete Freund's adjuvant (CFA)-induced orofacial pain, involving finding the shift point regarding small molecule neurotransmitter concentrations changes vs. that of the previously characterized headache-related neuropeptides. The investigated neurotransmitters consisted of glutamate, γ-aminobutyric acid, noradrenalin and serotonin. Furthermore, in light of its influence on glutamatergic neurotransmission, we measured the level of kynurenic acid (KYNA) and its precursors in the kynurenine (KYN) pathway (KP) of tryptophan metabolism.The effect of CFA was evaluated in male Sprague Dawley rats. Animals were injected with CFA (1 mg/ml, 50 μl/animal) into the right whisker pad. We applied high-performance liquid chromatography to determine the concentrations of the above-mentioned compounds from the trigeminal nucleus caudalis (TNC) and somatosensory cortex (ssCX) of rats. Furthermore, we measured some of these metabolites from the cerebrospinal fluid and plasma as well. Afterwards, we carried out permutation t-tests as post hoc analysis for pairwise comparison.Our results demonstrated that 24 h after CFA treatment, the level of glutamate, KYNA and that of its precursor, KYN was still elevated in the TNC, all diminishing by 48 h. In the ssCX, significant concentration increases of KYNA and serotonin were found.This is the first study assessing neurotransmitter changes in the TNC and ssCX following CFA treatment, confirming the dominant role of glutamate in early pain processing and a compensatory elevation of KYNA with anti-glutamatergic properties. Furthermore, the current findings draw attention to the limited time interval where medications can target the glutamatergic pathways." @default.
• W3017107596 created "2020-04-24" @default.
• W3017107596 creator A5004326925 @default.
• W3017107596 creator A5005274128 @default.
• W3017107596 creator A5008364196 @default.
• W3017107596 creator A5016258023 @default.
• W3017107596 creator A5035093314 @default.
• W3017107596 creator A5045790555 @default.
• W3017107596 creator A5057907020 @default.
• W3017107596 creator A5071179672 @default.
• W3017107596 creator A5078936689 @default.
• W3017107596 creator A5090527299 @default.
• W3017107596 date "2020-04-21" @default.
• W3017107596 modified "2023-10-15" @default.
• W3017107596 title "Neurotransmitter and tryptophan metabolite concentration changes in the complete Freund’s adjuvant model of orofacial pain" @default.
• W3017107596 cites W1536136614 @default.
• W3017107596 cites W1543274849 @default.
• W3017107596 cites W1968935486 @default.
• W3017107596 cites W1973081422 @default.
• W3017107596 cites W1973413068 @default.
• W3017107596 cites W1974512593 @default.
• W3017107596 cites W1976502580 @default.
• W3017107596 cites W1978565834 @default.
• W3017107596 cites W1982737489 @default.
• W3017107596 cites W1987485485 @default.
• W3017107596 cites W1990013738 @default.
• W3017107596 cites W1990516752 @default.
• W3017107596 cites W1996177596 @default.
• W3017107596 cites W1996580716 @default.
• W3017107596 cites W2003283695 @default.
• W3017107596 cites W2003760083 @default.
• W3017107596 cites W2010252509 @default.
• W3017107596 cites W2010713665 @default.
• W3017107596 cites W2012782470 @default.
• W3017107596 cites W2020557792 @default.
• W3017107596 cites W2023779727 @default.
• W3017107596 cites W2024583380 @default.
• W3017107596 cites W2024707503 @default.
• W3017107596 cites W2027336204 @default.
• W3017107596 cites W2041323587 @default.
• W3017107596 cites W2053175792 @default.
• W3017107596 cites W2058687732 @default.
• W3017107596 cites W2060792410 @default.
• W3017107596 cites W2061102454 @default.
• W3017107596 cites W2065358147 @default.
• W3017107596 cites W2066869040 @default.
• W3017107596 cites W2067494870 @default.
• W3017107596 cites W2069370488 @default.
• W3017107596 cites W2070763795 @default.
• W3017107596 cites W2072442157 @default.
• W3017107596 cites W2077427606 @default.
• W3017107596 cites W2083386201 @default.
• W3017107596 cites W2084911947 @default.
• W3017107596 cites W2084970044 @default.
• W3017107596 cites W2085970203 @default.
• W3017107596 cites W2100880723 @default.
• W3017107596 cites W2108344016 @default.
• W3017107596 cites W2108655765 @default.
• W3017107596 cites W2108941381 @default.
• W3017107596 cites W2109366245 @default.
• W3017107596 cites W2120208239 @default.
• W3017107596 cites W2122642594 @default.
• W3017107596 cites W2124879125 @default.
• W3017107596 cites W2141092268 @default.
• W3017107596 cites W2145053905 @default.
• W3017107596 cites W2148088449 @default.
• W3017107596 cites W2150300556 @default.
• W3017107596 cites W2154855467 @default.
• W3017107596 cites W2155245252 @default.
• W3017107596 cites W2159388899 @default.
• W3017107596 cites W2167121838 @default.
• W3017107596 cites W2171690527 @default.
• W3017107596 cites W2245128406 @default.
• W3017107596 cites W2306954358 @default.
• W3017107596 cites W2307405065 @default.
• W3017107596 cites W2333255806 @default.
• W3017107596 cites W2342820855 @default.
• W3017107596 cites W2519364805 @default.
• W3017107596 cites W2527778140 @default.
• W3017107596 cites W2528385426 @default.
• W3017107596 cites W2541569759 @default.
• W3017107596 cites W2593999046 @default.
• W3017107596 cites W2600119935 @default.
• W3017107596 cites W260396355 @default.
• W3017107596 cites W2603968264 @default.
• W3017107596 cites W2613194071 @default.
• W3017107596 cites W2623042297 @default.
• W3017107596 cites W2751893154 @default.
• W3017107596 cites W2784122121 @default.
• W3017107596 cites W2789970806 @default.
• W3017107596 cites W2790632305 @default.
• W3017107596 cites W2795835597 @default.
• W3017107596 cites W2800936510 @default.
• W3017107596 cites W2804058954 @default.
• W3017107596 cites W2807660320 @default.
• W3017107596 cites W2849561320 @default.
• W3017107596 cites W2892050951 @default.
• W3017107596 cites W2921332535 @default.
• W3017107596 cites W2947158236 @default.
• W3017107596 cites W2971348120 @default.

• next