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- W3017153222 abstract "Adult hippocampal neurogenesis is strongly dependent on thyroid hormone (TH). Whether TH signaling regulates this process in a cell-autonomous or non-autonomous manner remains unknown. To answer this question, we used global and conditional knockouts of the TH transporter monocarboxylate transporter 8 (MCT8), having first used FACS and immunohistochemistry to demonstrate that MCT8 is the only TH transporter expressed on neuroblasts and adult slice cultures to confirm a necessary role for MCT8 in neurogenesis. Both mice with a global deletion or an adult neural stem cell-specific deletion of MCT8 showed decreased expression of the cell-cycle inhibitor P27KIP1, reduced differentiation of neuroblasts, and impaired generation of new granule cell neurons, with global knockout mice also showing enhanced neuroblast proliferation. Together, our results reveal a cell-autonomous role for TH signaling in adult hippocampal neurogenesis alongside non-cell-autonomous effects on cell proliferation earlier in the lineage." @default.
- W3017153222 created "2020-04-24" @default.
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- W3017153222 date "2020-05-01" @default.
- W3017153222 modified "2023-10-13" @default.
- W3017153222 title "Hippocampal Neurogenesis Requires Cell-Autonomous Thyroid Hormone Signaling" @default.
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- W3017153222 doi "https://doi.org/10.1016/j.stemcr.2020.03.014" @default.
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