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• W3017235341 abstract "Abstract Background The mechanism underlying the occurrence of the J wave in low temperature remains unclear. However, low temperature is associated with metabolic disorder and 5' AMP‐activated protein kinase (AMPK), which modulates ionic currents and cardiac metabolism. This study investigated whether AMPK regulation can modulate the occurrence of the J wave at low temperature. Methods Unipolar and bipolar leads were used to record monophasic action potential (the endocardium and epicardium) and pseudo‐electrocardiograms (inferior leads) to study the cardiac electrical activity. Measurements were taken in isolated Langendorff rabbit hearts at both 30℃ and 37℃ before and after administration of 4‐aminopyridine (an ultrarapid delayed rectifier potassium current inhibitor, I Kur , 50 µmol L −1 ), PF06409577 (an AMPK activator, 1 µmol L −1 ), compound C (an AMPK inhibitor, 10 µmol L −1 ) and glibenclamide (an ATP‐sensitive inward rectifier potassium channel inhibitor, I KATP , 20 µmol L −1 ). Results The amplitude of the J wave (2.46 ± 0.34 mV vs. 1.11 ± 0.23 mV, P < .01) at 30℃ (n = 15) was larger than that at 37℃ (n = 15). PF06409577 (1 µmol L −1 ) increased the J waves at both 30℃ and 37℃. In contrast, compound C (10 µmol L −1 ) reduced J wave at both 37℃ and 30℃. Low‐temperature‐induced J waves were individually suppressed by 4‐AP (50 µmol L −1 ) and glibenclamide (20 µmol L −1 ). Conclusions AMPK inhibition reduces low‐temperature‐induced J waves and possible ventricular arrhythmogenesis by modulating I KATP and I Kur channels." @default.
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• W3017235341 date "2020-05-15" @default.
• W3017235341 modified "2023-10-10" @default.
• W3017235341 title "The AMP‐activated protein kinase modulates hypothermia‐induced J wave" @default.
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• W3017235341 doi "https://doi.org/10.1111/eci.13247" @default.
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