FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3017241775> ?p ?o ?g. }

• W3017241775 endingPage "e0231972" @default.
• W3017241775 startingPage "e0231972" @default.
• W3017241775 abstract "At present, a large number of studies have reported that hydrogen has antioxidant functions and prevents oxidative stress damage. However, it is not clear whether hydrogen can prolong longevity based on these effects. Therefore, we studied and explored the antiaging potential of exogenous hydrogen and its ability to extend longevity using Caenorhabditis elegans (C. elegans) as an animal model. Our results showed that the lifespans of the N2, sod-3 and sod-5 mutant strains were extended by approximately 22.7%, 9.5%, and 8.7%, respectively, after hydrogen treatment, but hydrogen had no effect on the lifespans of the daf-2 and daf-16 mutant strains. Meanwhile, the level of reactive oxygen species (ROS) in the hydrogen treatment group was significantly lower than that in the control group. At the transcript level, the expression of age-1 and let-363 was obviously decreased, while the expression of ins-18 was increased at the same time point (14 d). Compared with the control group, paraquat (PQ) could reduce the lifespan of the N2 and sod-5 mutant strains. Importantly, the longevity of these mutant strains recovered to normal levels when the animals were treated with exogenous hydrogen. According to these results, the lifespan of C. elegans is closely related to oxidative stress and can be significantly prolonged by reducing oxidative stress damage. Taken together, our data showed that hydrogen is a valuable antioxidant that can significantly reduce the body's ROS levels and extend the lifespan of C. elegans. This study also laid a foundation for the subsequent application of hydrogen in antiaging studies." @default.
• W3017241775 created "2020-04-24" @default.
• W3017241775 creator A5000894136 @default.
• W3017241775 creator A5012857374 @default.
• W3017241775 creator A5036031567 @default.
• W3017241775 creator A5052778171 @default.
• W3017241775 creator A5080662237 @default.
• W3017241775 creator A5090819151 @default.
• W3017241775 date "2020-04-22" @default.
• W3017241775 modified "2023-10-11" @default.
• W3017241775 title "Hydrogen extends Caenorhabditis elegans longevity by reducing reactive oxygen species" @default.
• W3017241775 cites W1938310987 @default.
• W3017241775 cites W1940436875 @default.
• W3017241775 cites W1943519585 @default.
• W3017241775 cites W1963789809 @default.
• W3017241775 cites W1965414585 @default.
• W3017241775 cites W1971058433 @default.
• W3017241775 cites W1976654687 @default.
• W3017241775 cites W1979705609 @default.
• W3017241775 cites W1982647833 @default.
• W3017241775 cites W1985299574 @default.
• W3017241775 cites W1987815360 @default.
• W3017241775 cites W1998104906 @default.
• W3017241775 cites W2033350584 @default.
• W3017241775 cites W2038279476 @default.
• W3017241775 cites W2054256473 @default.
• W3017241775 cites W2059745607 @default.
• W3017241775 cites W2068939472 @default.
• W3017241775 cites W2089071989 @default.
• W3017241775 cites W2132826785 @default.
• W3017241775 cites W2134975446 @default.
• W3017241775 cites W2169657429 @default.
• W3017241775 cites W2216787670 @default.
• W3017241775 cites W2230204591 @default.
• W3017241775 cites W2296334259 @default.
• W3017241775 cites W2315512556 @default.
• W3017241775 cites W2395616623 @default.
• W3017241775 cites W2535649952 @default.
• W3017241775 cites W2587676932 @default.
• W3017241775 cites W2591210164 @default.
• W3017241775 cites W2593816418 @default.
• W3017241775 cites W2612641650 @default.
• W3017241775 cites W2616612259 @default.
• W3017241775 cites W2804071071 @default.
• W3017241775 cites W2885006502 @default.
• W3017241775 cites W2988046530 @default.
• W3017241775 cites W2996848303 @default.
• W3017241775 doi "https://doi.org/10.1371/journal.pone.0231972" @default.
• W3017241775 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7176462" @default.
• W3017241775 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32320994" @default.
• W3017241775 hasPublicationYear "2020" @default.
• W3017241775 type Work @default.
• W3017241775 sameAs 3017241775 @default.
• W3017241775 citedByCount "7" @default.
• W3017241775 countsByYear W30172417752020 @default.
• W3017241775 countsByYear W30172417752021 @default.
• W3017241775 countsByYear W30172417752022 @default.
• W3017241775 countsByYear W30172417752023 @default.
• W3017241775 crossrefType "journal-article" @default.
• W3017241775 hasAuthorship W3017241775A5000894136 @default.
• W3017241775 hasAuthorship W3017241775A5012857374 @default.
• W3017241775 hasAuthorship W3017241775A5036031567 @default.
• W3017241775 hasAuthorship W3017241775A5052778171 @default.
• W3017241775 hasAuthorship W3017241775A5080662237 @default.
• W3017241775 hasAuthorship W3017241775A5090819151 @default.
• W3017241775 hasBestOaLocation W30172417751 @default.
• W3017241775 hasConcept C104317684 @default.
• W3017241775 hasConcept C143065580 @default.
• W3017241775 hasConcept C2776151105 @default.
• W3017241775 hasConcept C2776527163 @default.
• W3017241775 hasConcept C2776759703 @default.
• W3017241775 hasConcept C2778004101 @default.
• W3017241775 hasConcept C2778944004 @default.
• W3017241775 hasConcept C2778979269 @default.
• W3017241775 hasConcept C48349386 @default.
• W3017241775 hasConcept C54355233 @default.
• W3017241775 hasConcept C55493867 @default.
• W3017241775 hasConcept C86803240 @default.
• W3017241775 hasConcept C95444343 @default.
• W3017241775 hasConceptScore W3017241775C104317684 @default.
• W3017241775 hasConceptScore W3017241775C143065580 @default.
• W3017241775 hasConceptScore W3017241775C2776151105 @default.
• W3017241775 hasConceptScore W3017241775C2776527163 @default.
• W3017241775 hasConceptScore W3017241775C2776759703 @default.
• W3017241775 hasConceptScore W3017241775C2778004101 @default.
• W3017241775 hasConceptScore W3017241775C2778944004 @default.
• W3017241775 hasConceptScore W3017241775C2778979269 @default.
• W3017241775 hasConceptScore W3017241775C48349386 @default.
• W3017241775 hasConceptScore W3017241775C54355233 @default.
• W3017241775 hasConceptScore W3017241775C55493867 @default.
• W3017241775 hasConceptScore W3017241775C86803240 @default.
• W3017241775 hasConceptScore W3017241775C95444343 @default.
• W3017241775 hasFunder F4320335777 @default.
• W3017241775 hasIssue "4" @default.
• W3017241775 hasLocation W30172417751 @default.
• W3017241775 hasLocation W30172417752 @default.
• W3017241775 hasLocation W30172417753 @default.
• W3017241775 hasLocation W30172417754 @default.

• next