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- W3017248124 abstract "Necrosis-avid agents possess exploitable theragnostic utilities including evaluation of tissue viability, monitoring of therapeutic efficacy as well as diagnosis and treatment of necrosis-related disorders. Rhein (4,5-dihydroxyl-2-carboxylic-9,10-dihydrodiketoanthracene), a naturally occurring monomeric anthraquinone compound extensively found in medicinal herbs, was recently demonstrated to have a newly discovered necrosis-avid trait and to show promising application in necrosis imaging. In this overview, we present the discovering process of rhein as a new necrosis-avid agent as well as its potential imaging applications in visualisation of myocardial necrosis and early evaluation of tumour response to therapy. Moreover, the molecular mechanism exploration of necrosis avidity behind rhein are also presented. The discovery of necrosis avidity with rhein and the development of rhein-based molecular probes may further expand the scope of necrosis-avid compounds and highlight the potential utility of necrosis-avid molecular probes in necrosis imaging." @default.
- W3017248124 created "2020-04-24" @default.
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- W3017248124 creator A5052311485 @default.
- W3017248124 creator A5057209439 @default.
- W3017248124 creator A5084351198 @default.
- W3017248124 date "2020-04-30" @default.
- W3017248124 modified "2023-10-16" @default.
- W3017248124 title "Discovery of necrosis avidity of rhein and its applications in necrosis imaging" @default.
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- W3017248124 doi "https://doi.org/10.1080/1061186x.2020.1759079" @default.
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- W3017248124 hasPublicationYear "2020" @default.
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