FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3017293526> ?p ?o ?g. }

• W3017293526 endingPage "1" @default.
• W3017293526 startingPage "1" @default.
• W3017293526 abstract "Adequate skeletal perfusion is necessary to maintain bone remodeling processes, and decrements in bone arterial function and regional blood flow may lead to conditions such as osteoporosis. Aging elicits progressive bone loss, associated with impaired bone vasomotor function and perfusion, that can lead to osteoporosis. Although these age-related adaptations are ameliorated via exercise training, the specific mechanisms underlying exercise-induced alterations of bone vasomotor function with aging remain largely unknown. The purpose of this study was to elucidate the age- and exercise-induced vasomotor adaptations of the bone principal nutrient artery and subsequent alterations in bone blood flow. Young and old male Fischer-344 rats underwent treadmill exercise training (15 m/min, 15° incline, 1hr/day, 5 days/wk for 10–12 wks) or remained sedentary in cages. At the end of the experimental period, the femoral principal nutrient artery (PNA) was isolated, cannulated, and pressurized for vascular response studies. Vasoconstrictor responses of the PNA were assessed in vitro using α-adrenergic agonist phenylephrine (PE, 10−9–10−4 M), receptor-independent potassium chloride (KCl, 10–100 mM) and myogenic responsiveness to increasing intraluminal pressure (0 to 140 cmH2O). Endothelium-dependent (ACh, 10−9–10−4 M) and -independent (Dea-NONOate, 10−9–10−4 M) vasodilator responses were also evaluated. Additionally, regional blood flow to the femur was measured at rest and during exercise using radiolabeled microspheres. Vasomotor responses to agonists for constriction (PE, KCl) and dilation (ACh, Dea-NONOate) decreased with aging. In contrast, myogenic responsiveness in old rats was greater compared with young rats (p<0.05). Vasoconstrictor response to KCl was greater after training in both young and old rats as compared to the sedentary rats. Exercise-trained old rats also showed increased vasoconstrictor responses to PE and myogenic responsiveness; however, no significant difference was shown in young rats (p<0.05). Exercise training enhanced endothelium-dependent vasodilation in both young and old rats; however, no significant exercise effect was observed in endothelium-independent vasodilation (p<0.05). Regional femur blood flow to the proximal and distal metaphysis and epiphysis, as well as diaphyseal marrow, was lower in aged rats compared to young rats at rest. However, exercise-trained old rats showed significantly increased regional blood flow during exercise compared with old SED rats (p<0.05). These results demonstrate vasomotor responses are impaired in the femoral PNA from aged rats; however, endurance training intervention at advancing age can reverse vasomotor deficits including vasoconstrictor and vasodilator response in bone resistance arteries and enhance regional bone and marrow blood flow. Such changes in bone and marrow perfusion could play an important role in enhancing the quality and strength of bone in old age following exercise training. Support or Funding Information NIH grant AG055029" @default.
• W3017293526 created "2020-04-24" @default.
• W3017293526 creator A5000910403 @default.
• W3017293526 creator A5006771820 @default.
• W3017293526 creator A5036089203 @default.
• W3017293526 creator A5044948647 @default.
• W3017293526 creator A5047630765 @default.
• W3017293526 creator A5054541179 @default.
• W3017293526 creator A5062098372 @default.
• W3017293526 creator A5064659293 @default.
• W3017293526 creator A5081975706 @default.
• W3017293526 creator A5082343607 @default.
• W3017293526 creator A5089025967 @default.
• W3017293526 date "2020-04-01" @default.
• W3017293526 modified "2023-09-26" @default.
• W3017293526 title "Effects of Aging and Exercise Training on Vasomotor Function of Bone Resistance Arteries and Bone Blood Flow" @default.
• W3017293526 doi "https://doi.org/10.1096/fasebj.2020.34.s1.03210" @default.
• W3017293526 hasPublicationYear "2020" @default.
• W3017293526 type Work @default.
• W3017293526 sameAs 3017293526 @default.
• W3017293526 citedByCount "0" @default.
• W3017293526 crossrefType "journal-article" @default.
• W3017293526 hasAuthorship W3017293526A5000910403 @default.
• W3017293526 hasAuthorship W3017293526A5006771820 @default.
• W3017293526 hasAuthorship W3017293526A5036089203 @default.
• W3017293526 hasAuthorship W3017293526A5044948647 @default.
• W3017293526 hasAuthorship W3017293526A5047630765 @default.
• W3017293526 hasAuthorship W3017293526A5054541179 @default.
• W3017293526 hasAuthorship W3017293526A5062098372 @default.
• W3017293526 hasAuthorship W3017293526A5064659293 @default.
• W3017293526 hasAuthorship W3017293526A5081975706 @default.
• W3017293526 hasAuthorship W3017293526A5082343607 @default.
• W3017293526 hasAuthorship W3017293526A5089025967 @default.
• W3017293526 hasBestOaLocation W30172935261 @default.
• W3017293526 hasConcept C120770815 @default.
• W3017293526 hasConcept C126322002 @default.
• W3017293526 hasConcept C134018914 @default.
• W3017293526 hasConcept C170033053 @default.
• W3017293526 hasConcept C2776214587 @default.
• W3017293526 hasConcept C2776541429 @default.
• W3017293526 hasConcept C2777952589 @default.
• W3017293526 hasConcept C2779961880 @default.
• W3017293526 hasConcept C71924100 @default.
• W3017293526 hasConcept C84393581 @default.
• W3017293526 hasConceptScore W3017293526C120770815 @default.
• W3017293526 hasConceptScore W3017293526C126322002 @default.
• W3017293526 hasConceptScore W3017293526C134018914 @default.
• W3017293526 hasConceptScore W3017293526C170033053 @default.
• W3017293526 hasConceptScore W3017293526C2776214587 @default.
• W3017293526 hasConceptScore W3017293526C2776541429 @default.
• W3017293526 hasConceptScore W3017293526C2777952589 @default.
• W3017293526 hasConceptScore W3017293526C2779961880 @default.
• W3017293526 hasConceptScore W3017293526C71924100 @default.
• W3017293526 hasConceptScore W3017293526C84393581 @default.
• W3017293526 hasIssue "S1" @default.
• W3017293526 hasLocation W30172935261 @default.
• W3017293526 hasOpenAccess W3017293526 @default.
• W3017293526 hasPrimaryLocation W30172935261 @default.
• W3017293526 hasRelatedWork W1556367950 @default.
• W3017293526 hasRelatedWork W1561198074 @default.
• W3017293526 hasRelatedWork W1998567660 @default.
• W3017293526 hasRelatedWork W2115582809 @default.
• W3017293526 hasRelatedWork W2117062737 @default.
• W3017293526 hasRelatedWork W2152412226 @default.
• W3017293526 hasRelatedWork W2154871933 @default.
• W3017293526 hasRelatedWork W2188696810 @default.
• W3017293526 hasRelatedWork W2314941988 @default.
• W3017293526 hasRelatedWork W2363908187 @default.
• W3017293526 hasVolume "34" @default.
• W3017293526 isParatext "false" @default.
• W3017293526 isRetracted "false" @default.
• W3017293526 magId "3017293526" @default.
• W3017293526 workType "article" @default.