FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3017303018> ?p ?o ?g. }

• W3017303018 endingPage "396" @default.
• W3017303018 startingPage "387" @default.
• W3017303018 abstract "Background: Hepatocellular carcinoma (HCC) is an aggressive primary hepatic cancer with high malignancy and poor prognosis. Long noncoding RNA HOTAIR has been classified as an oncogene to accelerate cell proliferation, migration, and invasion in many cancer types by interacting with the miRNA. Therefore, we assumed that HOTAIR might participate in HCC cell progression by interacting with miR-217-5p expression. Materials and Methods: The expression of HOTAIR and miR-217-5p in 35 HCC patients and HCC cells was measured by quantitative real-time polymerase chain reaction. Cell transfection was conducted using Lipofectamine 2000 transfection reagent. CCK8 and flow cytometry was applied for the measurement of cell proliferation and apoptosis. Cell migration and invasion capacities were carried out by transwell assay. Xenograft mice were constructed by subcutaneously injecting of stably transfected Huh-7 cells in mice. The interaction between HOTAIR and miR-217-5p was determined by luciferase reporter system. Protein expression of P13K, p-P13K, AKT, p-AKT, MMP-2, and MMP-9 was analyzed using Western blot assay. Results: The expression of HOTAIR was upregulated, whereas miR-217-5p was downregulated in HCC tumor tissues and cell lines (Hep3B and Huh-7) compared with normal tissues and human normal liver cell line MIHA. In addition, HOTAIR expression was negatively correlated with miR-217-5p expression in HCC (r2 = 0.1867, p = 0.0171). More importantly, HOTAIR knockdown induced apoptosis and inhibited cell proliferation, migration, invasion, and epithelial-mesenchymal transition (EMT). In vivo experiments revealed that the interference of HOTAIR inhibited tumor growth. Subsequently, luciferase reporter system confirmed the interaction between HOTAIR and miR-217-5p. The rescue experiments clarified that miR-217-5p inhibitor attenuated the suppression of HOTAIR silencing on HCC cell proliferation, migration, invasion, and EMT. Furthermore, miR-217-5p inhibitor restored the inhibition of HOTAIR silencing mediated p-PI3K/p-AKT/MMP-2/9 protein expression. Conclusions:HOTAIR contributes to cell progression in HCC by sponging miR-217-5p, representing promising biomarkers for HCC treatment." @default.
• W3017303018 created "2020-04-24" @default.
• W3017303018 creator A5000877894 @default.
• W3017303018 creator A5086338661 @default.
• W3017303018 date "2020-06-01" @default.
• W3017303018 modified "2023-09-29" @default.
• W3017303018 title "<b><i>Retracted:</i></b> Long Noncoding RNA <i>HOTAIR</i> Contributes to Progression in Hepatocellular Carcinoma by Sponging <i>miR-217-5p</i>" @default.
• W3017303018 cites W2056593219 @default.
• W3017303018 cites W2146573461 @default.
• W3017303018 cites W2512070260 @default.
• W3017303018 cites W2552300896 @default.
• W3017303018 cites W2621543314 @default.
• W3017303018 cites W2755894008 @default.
• W3017303018 cites W2767767494 @default.
• W3017303018 cites W2799836092 @default.
• W3017303018 cites W2802099340 @default.
• W3017303018 cites W2804537586 @default.
• W3017303018 cites W2808395852 @default.
• W3017303018 cites W2809315334 @default.
• W3017303018 cites W2883170129 @default.
• W3017303018 cites W2889463948 @default.
• W3017303018 cites W2889600610 @default.
• W3017303018 cites W2889992809 @default.
• W3017303018 cites W2890737189 @default.
• W3017303018 cites W2892157950 @default.
• W3017303018 cites W2897240779 @default.
• W3017303018 cites W2898574296 @default.
• W3017303018 cites W2899949902 @default.
• W3017303018 cites W2904248391 @default.
• W3017303018 cites W2908264996 @default.
• W3017303018 cites W2912374763 @default.
• W3017303018 cites W2919377429 @default.
• W3017303018 cites W2921079547 @default.
• W3017303018 cites W2939038464 @default.
• W3017303018 cites W2940489329 @default.
• W3017303018 cites W2943072796 @default.
• W3017303018 cites W2943152130 @default.
• W3017303018 cites W2943931488 @default.
• W3017303018 cites W2944809728 @default.
• W3017303018 cites W4236599030 @default.
• W3017303018 doi "https://doi.org/10.1089/cbr.2019.3070" @default.
• W3017303018 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32315535" @default.
• W3017303018 hasPublicationYear "2020" @default.
• W3017303018 type Work @default.
• W3017303018 sameAs 3017303018 @default.
• W3017303018 citedByCount "17" @default.
• W3017303018 countsByYear W30173030182020 @default.
• W3017303018 countsByYear W30173030182021 @default.
• W3017303018 countsByYear W30173030182022 @default.
• W3017303018 countsByYear W30173030182023 @default.
• W3017303018 crossrefType "journal-article" @default.
• W3017303018 hasAuthorship W3017303018A5000877894 @default.
• W3017303018 hasAuthorship W3017303018A5086338661 @default.
• W3017303018 hasBestOaLocation W30173030181 @default.
• W3017303018 hasConcept C104317684 @default.
• W3017303018 hasConcept C127561419 @default.
• W3017303018 hasConcept C1491633281 @default.
• W3017303018 hasConcept C153911025 @default.
• W3017303018 hasConcept C173396325 @default.
• W3017303018 hasConcept C190283241 @default.
• W3017303018 hasConcept C22615655 @default.
• W3017303018 hasConcept C2781018059 @default.
• W3017303018 hasConcept C2781128886 @default.
• W3017303018 hasConcept C29537977 @default.
• W3017303018 hasConcept C502942594 @default.
• W3017303018 hasConcept C54009773 @default.
• W3017303018 hasConcept C54355233 @default.
• W3017303018 hasConcept C553184892 @default.
• W3017303018 hasConcept C55493867 @default.
• W3017303018 hasConcept C62112901 @default.
• W3017303018 hasConcept C62203573 @default.
• W3017303018 hasConcept C75217442 @default.
• W3017303018 hasConcept C81885089 @default.
• W3017303018 hasConcept C86803240 @default.
• W3017303018 hasConceptScore W3017303018C104317684 @default.
• W3017303018 hasConceptScore W3017303018C127561419 @default.
• W3017303018 hasConceptScore W3017303018C1491633281 @default.
• W3017303018 hasConceptScore W3017303018C153911025 @default.
• W3017303018 hasConceptScore W3017303018C173396325 @default.
• W3017303018 hasConceptScore W3017303018C190283241 @default.
• W3017303018 hasConceptScore W3017303018C22615655 @default.
• W3017303018 hasConceptScore W3017303018C2781018059 @default.
• W3017303018 hasConceptScore W3017303018C2781128886 @default.
• W3017303018 hasConceptScore W3017303018C29537977 @default.
• W3017303018 hasConceptScore W3017303018C502942594 @default.
• W3017303018 hasConceptScore W3017303018C54009773 @default.
• W3017303018 hasConceptScore W3017303018C54355233 @default.
• W3017303018 hasConceptScore W3017303018C553184892 @default.
• W3017303018 hasConceptScore W3017303018C55493867 @default.
• W3017303018 hasConceptScore W3017303018C62112901 @default.
• W3017303018 hasConceptScore W3017303018C62203573 @default.
• W3017303018 hasConceptScore W3017303018C75217442 @default.
• W3017303018 hasConceptScore W3017303018C81885089 @default.
• W3017303018 hasConceptScore W3017303018C86803240 @default.
• W3017303018 hasIssue "5" @default.
• W3017303018 hasLocation W30173030181 @default.
• W3017303018 hasLocation W30173030182 @default.
• W3017303018 hasOpenAccess W3017303018 @default.

• next