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- W3017334080 abstract "The reconsolidation and extinction of aversive memories and their boundary conditions have been extensively studied. Knowing their network mechanisms may lead to the development of better strategies for the treatment of fear and anxiety-related disorders. In 2011, Osan et al. developed a computational model for exploring such phenomena based on attractor dynamics, Hebbian plasticity and synaptic degradation induced by prediction error. This model was able to explain, in a single formalism, experimental findings regarding the freezing behavior of rodents submitted to contextual fear conditioning. In 2017, through the study of inhibitory avoidance in rats, Radiske et al. showed that the previous knowledge of a context as non-aversive is a boundary condition for the reconsolidation of the shock memory subsequently experienced in that context. In the present work, by adapting the model of Osan et al. (2011) to simulate the experimental protocols of Radiske et al. (2017), we show that such boundary condition is compatible with the dynamics of an attractor network that supports synaptic labilization common to reconsolidation and extinction. Additionally, by varying parameters such as the levels of protein synthesis and degradation, we predict behavioral outcomes, and thus boundary conditions that can be tested experimentally." @default.
- W3017334080 created "2020-04-24" @default.
- W3017334080 creator A5057423073 @default.
- W3017334080 creator A5082342136 @default.
- W3017334080 date "2020-07-01" @default.
- W3017334080 modified "2023-09-26" @default.
- W3017334080 title "On the boundary conditions of avoidance memory reconsolidation: An attractor network perspective" @default.
- W3017334080 cites W1589010633 @default.
- W3017334080 cites W1608785134 @default.
- W3017334080 cites W1964259998 @default.
- W3017334080 cites W1970988011 @default.
- W3017334080 cites W1977532393 @default.
- W3017334080 cites W1977798186 @default.
- W3017334080 cites W1979751654 @default.
- W3017334080 cites W1982333295 @default.
- W3017334080 cites W1983540839 @default.
- W3017334080 cites W2000874341 @default.
- W3017334080 cites W2002734542 @default.
- W3017334080 cites W2007305681 @default.
- W3017334080 cites W2007653857 @default.
- W3017334080 cites W2012876560 @default.
- W3017334080 cites W2013517273 @default.
- W3017334080 cites W2018162107 @default.
- W3017334080 cites W2025672359 @default.
- W3017334080 cites W2026663553 @default.
- W3017334080 cites W2029548206 @default.
- W3017334080 cites W2036773579 @default.
- W3017334080 cites W2041465636 @default.
- W3017334080 cites W2041516961 @default.
- W3017334080 cites W2044179603 @default.
- W3017334080 cites W2045466646 @default.
- W3017334080 cites W2051902405 @default.
- W3017334080 cites W2058080450 @default.
- W3017334080 cites W2061233919 @default.
- W3017334080 cites W2062912896 @default.
- W3017334080 cites W2071845794 @default.
- W3017334080 cites W2072570863 @default.
- W3017334080 cites W2072724677 @default.
- W3017334080 cites W2073708754 @default.
- W3017334080 cites W2074222476 @default.
- W3017334080 cites W2076345622 @default.
- W3017334080 cites W2081961955 @default.
- W3017334080 cites W2088903528 @default.
- W3017334080 cites W2089059900 @default.
- W3017334080 cites W2091064369 @default.
- W3017334080 cites W2093069982 @default.
- W3017334080 cites W2093235773 @default.
- W3017334080 cites W2105089471 @default.
- W3017334080 cites W2114465430 @default.
- W3017334080 cites W2119051448 @default.
- W3017334080 cites W2119885245 @default.
- W3017334080 cites W2120485135 @default.
- W3017334080 cites W2121007598 @default.
- W3017334080 cites W2123663795 @default.
- W3017334080 cites W2128084896 @default.
- W3017334080 cites W2128283823 @default.
- W3017334080 cites W2130106262 @default.
- W3017334080 cites W2133083344 @default.
- W3017334080 cites W2140817479 @default.
- W3017334080 cites W2142925815 @default.
- W3017334080 cites W2146165206 @default.
- W3017334080 cites W2146460558 @default.
- W3017334080 cites W2147008239 @default.
- W3017334080 cites W2148764920 @default.
- W3017334080 cites W2155547196 @default.
- W3017334080 cites W2157518752 @default.
- W3017334080 cites W2159475829 @default.
- W3017334080 cites W2161113761 @default.
- W3017334080 cites W2162958801 @default.
- W3017334080 cites W2168204169 @default.
- W3017334080 cites W2172149172 @default.
- W3017334080 cites W2327209428 @default.
- W3017334080 cites W2344667183 @default.
- W3017334080 cites W2410479170 @default.
- W3017334080 cites W2604988916 @default.
- W3017334080 cites W2612356851 @default.
- W3017334080 cites W2617413315 @default.
- W3017334080 cites W2746305777 @default.
- W3017334080 cites W2753646780 @default.
- W3017334080 cites W2768516711 @default.
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- W3017334080 cites W2969678152 @default.
- W3017334080 cites W2971432862 @default.
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- W3017334080 doi "https://doi.org/10.1016/j.neunet.2020.04.013" @default.
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- W3017334080 hasPublicationYear "2020" @default.
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