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- W3017335458 abstract "Mitochondria play an important role in numerous processes, including energy generation, regulating ion homeostasis, and cell signaling. Mitochondria are also the main source of reactive oxygen species (ROS). Due to the oxidative environment within mitochondria, the macromolecules therein, for example, mtDNA, proteins, and lipids are more susceptible to sustaining damage. During aging, mitochondrial functions decline, partly as a result of an accumulation of mtDNA mutations, decreased mtDNA copy number and protein expression, and a reduction in oxidative capacity. The aim of this study was to summarize the knowledge on DNA oxidative damage in aging and age-related neurodegenerative diseases. It has been hypothesized that various ROS may play an important role not only in physiological senescence but also in the development of neurodegenerative diseases, for example, Alzheimer's disease and Parkinson's disease. Thus, mitochondria seem to be a potential target of novel treatments for neurodegenerative diseases." @default.
- W3017335458 created "2020-04-24" @default.
- W3017335458 creator A5023111093 @default.
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- W3017335458 creator A5081734923 @default.
- W3017335458 date "2020-08-01" @default.
- W3017335458 modified "2023-10-11" @default.
- W3017335458 title "Mitochondrial and Nuclear DNA Oxidative Damage in Physiological and Pathological Aging" @default.
- W3017335458 cites W123195486 @default.
- W3017335458 cites W1450758155 @default.
- W3017335458 cites W1487243507 @default.
- W3017335458 cites W1503983308 @default.
- W3017335458 cites W1532873251 @default.
- W3017335458 cites W1833739857 @default.
- W3017335458 cites W1913796783 @default.
- W3017335458 cites W1964382334 @default.
- W3017335458 cites W1968346496 @default.
- W3017335458 cites W1971160716 @default.
- W3017335458 cites W1979369962 @default.
- W3017335458 cites W1982647833 @default.
- W3017335458 cites W1987379856 @default.
- W3017335458 cites W1987885263 @default.
- W3017335458 cites W1989420290 @default.
- W3017335458 cites W1989810429 @default.
- W3017335458 cites W1990171977 @default.
- W3017335458 cites W1990353436 @default.
- W3017335458 cites W1990811092 @default.
- W3017335458 cites W1992423211 @default.
- W3017335458 cites W1992958009 @default.
- W3017335458 cites W1993781471 @default.
- W3017335458 cites W1994619720 @default.
- W3017335458 cites W1998171008 @default.
- W3017335458 cites W2000396570 @default.
- W3017335458 cites W2004904888 @default.
- W3017335458 cites W2010179451 @default.
- W3017335458 cites W2011727503 @default.
- W3017335458 cites W2021460489 @default.
- W3017335458 cites W2024533804 @default.
- W3017335458 cites W2025564854 @default.
- W3017335458 cites W2026970282 @default.
- W3017335458 cites W2030477444 @default.
- W3017335458 cites W2032350023 @default.
- W3017335458 cites W2045416175 @default.
- W3017335458 cites W2049972682 @default.
- W3017335458 cites W2051274874 @default.
- W3017335458 cites W2052210065 @default.
- W3017335458 cites W2052742260 @default.
- W3017335458 cites W2052815889 @default.
- W3017335458 cites W2053779702 @default.
- W3017335458 cites W2055308573 @default.
- W3017335458 cites W2055346161 @default.
- W3017335458 cites W2056293127 @default.
- W3017335458 cites W2056585943 @default.
- W3017335458 cites W2056620406 @default.
- W3017335458 cites W2056648984 @default.
- W3017335458 cites W2060626022 @default.
- W3017335458 cites W2062603557 @default.
- W3017335458 cites W2064308541 @default.
- W3017335458 cites W2067195259 @default.
- W3017335458 cites W2067656585 @default.
- W3017335458 cites W2070982075 @default.
- W3017335458 cites W2076241970 @default.
- W3017335458 cites W2076554838 @default.
- W3017335458 cites W2076740879 @default.
- W3017335458 cites W2076951953 @default.
- W3017335458 cites W2077640472 @default.
- W3017335458 cites W2078710187 @default.
- W3017335458 cites W2078868796 @default.
- W3017335458 cites W2084391189 @default.
- W3017335458 cites W2091217262 @default.
- W3017335458 cites W2095210160 @default.
- W3017335458 cites W2101802274 @default.
- W3017335458 cites W2103024032 @default.
- W3017335458 cites W2104615592 @default.
- W3017335458 cites W2109291482 @default.
- W3017335458 cites W2113547127 @default.
- W3017335458 cites W2117671645 @default.
- W3017335458 cites W2119278281 @default.
- W3017335458 cites W2121966499 @default.
- W3017335458 cites W2126773395 @default.
- W3017335458 cites W2130753450 @default.
- W3017335458 cites W2133103790 @default.
- W3017335458 cites W2140075873 @default.
- W3017335458 cites W2140190549 @default.
- W3017335458 cites W2144602958 @default.
- W3017335458 cites W2146002095 @default.
- W3017335458 cites W2147101735 @default.
- W3017335458 cites W2153455224 @default.
- W3017335458 cites W2154111088 @default.
- W3017335458 cites W2167764101 @default.
- W3017335458 cites W2168126136 @default.
- W3017335458 cites W2169020430 @default.
- W3017335458 cites W2169817108 @default.
- W3017335458 cites W2170398463 @default.
- W3017335458 cites W2196369193 @default.