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• W3017380644 abstract "Abstract Background : Streptococcus mutans , considered as principal causative agent of dental caries, maintains a biofilm lifestyle in the dental plaque. The oral cavity harbors numerous S. mutans strains which displayed remarkable genotypic and phenotypic diversity. This study evaluated the genotypic and phenotypic diversity of S. mutans strains isolated from patients with dental caries and compared with the universal reference strain UA159. Methods : Selective cultivation on mitis-salivaries-bacitracin agar and species-specific polymerase chain reaction (PCR) was carried out to isolate and identify the 209 S. mutans isolates from 336 patients with dental caries. Arbitrarily primed polymerase chain reaction (AP-PCR), PCR amplification of specific gene, acid production, biofilm formation capacity, and deferred antagonism bacteriocin assay were performed to evaluate the genotypic and phenotypic variation. All statistical analysis was performed using the SPSS software version 20 (SPSS, Chicago, IL, USA). Results : Our study revealed a high degree of genotypic and phenotypic variability among the clinical strains. We observed significant differences in colony morphology, generation time, biofilm formation, bacteriocin and acid production while growing in culture medium. All the clinical isolates were able to lower pH while growing in Todd-Hewitt broth. Consistent with phenotypic variations, we also observed genotypic variation by AP-PCR and gene specific PCR. AP-PCR analysis suggested that most of the patients with dental caries have distinct type of S. mutans strains . Genes related to various two component systems were highly conserved among the isolated strains, however, bacteriocin encoding genes such as nlmAB , nlmC were absent in nearly half of the clinical isolates. Conclusions : Our study highlights the genotypic and phenotypic diversity of S. mutans clinical isolates and indicates the presence of diverse mechanism to initiate and establish the biofilm lifestyle which leads to tooth decay." @default.
• W3017380644 created "2020-04-24" @default.
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• W3017380644 date "2020-12-29" @default.
• W3017380644 modified "2023-09-27" @default.
• W3017380644 title "Genotypic and Phenotypic Characterization of Streptococcus Mutans Isolated From Dental Caries" @default.
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• W3017380644 doi "https://doi.org/10.21203/rs.3.rs-132779/v1" @default.
• W3017380644 hasPublicationYear "2020" @default.
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