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- W3017449457 abstract "Abstract Although 60 min-immobilization stress increased 3-methoxy-4-hydroxyphenyl-thyleneglycol sulfate (MHPG-SO4) level in various brain regions of rats, the stress-induced elevations of MHPG-SO4 level are partially attenuated by pretreatment with morphine (6mg/kg) and further enhanced by pretreatment with naloxone (5mg/kg) selectively in the hypothalamus, thalamus and amygdala. In order to study whether these effects of opioid agents in stressed rats is linked to some functional changes or merely to greatly enhanced noradrenaline (NA) release, the interaction of opioid agents and the NA system in the brain was examined 60 min after injections of methamphetamine (2,5mg/kg) and haloperidol (5mg/kg). Morphine attenuated the effects of amphetamine and haloperidol in the cerebral cortex and enhanced the effect of haloperidol in the hypothalamus. Naloxone failed to show an influence on the regional increases of MHPG-SO4 in methamphetamine treated rats, but attenuated the effect of haloperidol in the pons+medulla oblongata. These results indicate that stimulation or blockade of opiate receptors causes differential changes in acutely enhanced NA release in brain regions. The results also support our previous view that morphine and endogenous opioids act to relieve anxiety or fear in animals exposed to the stress partly by inhibiting the activity of noradrenergic neurons in the hypothalamus, thalamus and amygdala (Tanaka et al., Life Sci., 30, 1663, 1982; Tanaka et al., Brain Res., in press)." @default.
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- W3017449457 date "1983-01-01" @default.
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- W3017449457 title "Effects of morphine and naloxone on enhanced noradrenaline release in brain regions of haloperidol treated rats - comparative study on the effects of opioid agents in stressed and methamphetamine treated animals" @default.
- W3017449457 doi "https://doi.org/10.1016/s0021-5198(19)64818-3" @default.
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