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- W3017493685 abstract "Antigen-specific immunotherapies (ASIT) present compelling potential for introducing precision to the treatment of autoimmune diseases where nonspecific, global immunosuppression is currently the only treatment option. Central to ASIT design is the delivery of autoantigen, which parallels allergy desensitization approaches. Clinical success in tolerizing allergen-specific responses spans longer than a century, but autoimmune ASITs have yet to see an FDA-approved breakthrough. Allergens and autoantigens differ substantially in physicochemical properties, and these discrepancies influence the nature of their interactions with the immune system. Approved allergen-specific immunotherapies are typically administered as water soluble, neutrally charged protein fractions from 10 to 70 kDa. Conversely, autoantigens are native proteins that exhibit wide-ranging sizes, solubilities, and charges that render them susceptible to immunogenicity. To translate the success of allergen hyposensitization to ASIT, delivery strategies may be necessary to effectively format autoantigens, guide biodistribution, and engage appropriate immune mechanisms. • Antigen-specific immunotherapy (ASIT) seeks to introduce precision to autoimmune disease treatments. • Autoimmune ASIT principles parallel those of allergen desensitization regimens, but none have been FDA-approved to date. • Allergens and autoantigens differ substantially in physicochemical properties including size, solubility, and charge. • Drug delivery and biomaterial design strategies are likely necessary to overcome detrimental autoantigen properties." @default.
- W3017493685 created "2020-05-01" @default.
- W3017493685 creator A5049010871 @default.
- W3017493685 creator A5050936966 @default.
- W3017493685 creator A5052507833 @default.
- W3017493685 creator A5066191092 @default.
- W3017493685 creator A5090889599 @default.
- W3017493685 date "2020-01-01" @default.
- W3017493685 modified "2023-10-16" @default.
- W3017493685 title "Linking autoantigen properties to mechanisms of immunity" @default.
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