FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3017584156> ?p ?o ?g. }

• W3017584156 endingPage "2014" @default.
• W3017584156 startingPage "2014" @default.
• W3017584156 abstract "The sesquiterpene lactones eupatoriopicrin, estafietin, eupahakonenin B and minimolide have been isolated from Argentinean Astearaceae species and have been found to be active against Trypanosoma cruzi epimastigotes. The aim of this work was to evaluate the activity of these compounds by analyzing their effect against the stages of the parasites that are infective for the human. Even more interesting, we aimed to determine the effect of the most active and selective compound on an in vivo model of T. cruzi infection. Eupatoriopicrin was the most active against amastigotes and tripomastigotes (IC50 = 2.3 µg/mL, and 7.2 µg/mL, respectively) and displayed a high selectivity index. This compound was selected to study on an in vivo model of T. cruzi infection. The administration of 1 mg/kg/day of eupatoriopicrin for five consecutive days to infected mice produced a significant reduction in the parasitaemia levels in comparison with non-treated animals (area under parasitaemia curves 4.48 vs. 30.47, respectively). Skeletal muscular tissues from eupatopicrin-treated mice displayed only focal and interstitial lymphocyte inflammatory infiltrates and small areas of necrotic; by contrast, skeletal tissues from T. cruzi infected mice treated with the vehicle showed severe lymphocyte inflammatory infiltrates with necrosis of the adjacent myocytes. The results indicate that eupatoriopicrin could be considered a promising candidate for the development of new therapeutic agents for Chagas disease." @default.
• W3017584156 created "2020-05-01" @default.
• W3017584156 creator A5001727798 @default.
• W3017584156 creator A5003158924 @default.
• W3017584156 creator A5008746969 @default.
• W3017584156 creator A5021923098 @default.
• W3017584156 creator A5022619388 @default.
• W3017584156 creator A5031134164 @default.
• W3017584156 creator A5071367947 @default.
• W3017584156 creator A5074901091 @default.
• W3017584156 creator A5076759477 @default.
• W3017584156 creator A5077733914 @default.
• W3017584156 date "2020-04-25" @default.
• W3017584156 modified "2023-10-12" @default.
• W3017584156 title "Trypanocidal Activity of Four Sesquiterpene Lactones Isolated from Asteraceae Species" @default.
• W3017584156 cites W1963792340 @default.
• W3017584156 cites W1977098642 @default.
• W3017584156 cites W1977645089 @default.
• W3017584156 cites W1986834345 @default.
• W3017584156 cites W2007740910 @default.
• W3017584156 cites W2015826901 @default.
• W3017584156 cites W2021858407 @default.
• W3017584156 cites W2043714820 @default.
• W3017584156 cites W2048265476 @default.
• W3017584156 cites W2095997387 @default.
• W3017584156 cites W2100958335 @default.
• W3017584156 cites W2107367762 @default.
• W3017584156 cites W2145367956 @default.
• W3017584156 cites W2169488022 @default.
• W3017584156 cites W2169982530 @default.
• W3017584156 cites W2171765967 @default.
• W3017584156 cites W2333935186 @default.
• W3017584156 cites W2546811311 @default.
• W3017584156 cites W2780381661 @default.
• W3017584156 cites W2911095776 @default.
• W3017584156 cites W2913010358 @default.
• W3017584156 cites W2924347252 @default.
• W3017584156 cites W2970257708 @default.
• W3017584156 doi "https://doi.org/10.3390/molecules25092014" @default.
• W3017584156 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7248990" @default.
• W3017584156 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32344932" @default.
• W3017584156 hasPublicationYear "2020" @default.
• W3017584156 type Work @default.
• W3017584156 sameAs 3017584156 @default.
• W3017584156 citedByCount "18" @default.
• W3017584156 countsByYear W30175841562021 @default.
• W3017584156 countsByYear W30175841562022 @default.
• W3017584156 countsByYear W30175841562023 @default.
• W3017584156 crossrefType "journal-article" @default.
• W3017584156 hasAuthorship W3017584156A5001727798 @default.
• W3017584156 hasAuthorship W3017584156A5003158924 @default.
• W3017584156 hasAuthorship W3017584156A5008746969 @default.
• W3017584156 hasAuthorship W3017584156A5021923098 @default.
• W3017584156 hasAuthorship W3017584156A5022619388 @default.
• W3017584156 hasAuthorship W3017584156A5031134164 @default.
• W3017584156 hasAuthorship W3017584156A5071367947 @default.
• W3017584156 hasAuthorship W3017584156A5074901091 @default.
• W3017584156 hasAuthorship W3017584156A5076759477 @default.
• W3017584156 hasAuthorship W3017584156A5077733914 @default.
• W3017584156 hasBestOaLocation W30175841561 @default.
• W3017584156 hasConcept C112418997 @default.
• W3017584156 hasConcept C136764020 @default.
• W3017584156 hasConcept C150903083 @default.
• W3017584156 hasConcept C202751555 @default.
• W3017584156 hasConcept C203014093 @default.
• W3017584156 hasConcept C207001950 @default.
• W3017584156 hasConcept C26291073 @default.
• W3017584156 hasConcept C2776211264 @default.
• W3017584156 hasConcept C2777625466 @default.
• W3017584156 hasConcept C2777752497 @default.
• W3017584156 hasConcept C2779243328 @default.
• W3017584156 hasConcept C2781092759 @default.
• W3017584156 hasConcept C41008148 @default.
• W3017584156 hasConcept C503630168 @default.
• W3017584156 hasConcept C54355233 @default.
• W3017584156 hasConcept C55493867 @default.
• W3017584156 hasConcept C59822182 @default.
• W3017584156 hasConcept C71928629 @default.
• W3017584156 hasConcept C86803240 @default.
• W3017584156 hasConcept C98274493 @default.
• W3017584156 hasConcept C98319499 @default.
• W3017584156 hasConceptScore W3017584156C112418997 @default.
• W3017584156 hasConceptScore W3017584156C136764020 @default.
• W3017584156 hasConceptScore W3017584156C150903083 @default.
• W3017584156 hasConceptScore W3017584156C202751555 @default.
• W3017584156 hasConceptScore W3017584156C203014093 @default.
• W3017584156 hasConceptScore W3017584156C207001950 @default.
• W3017584156 hasConceptScore W3017584156C26291073 @default.
• W3017584156 hasConceptScore W3017584156C2776211264 @default.
• W3017584156 hasConceptScore W3017584156C2777625466 @default.
• W3017584156 hasConceptScore W3017584156C2777752497 @default.
• W3017584156 hasConceptScore W3017584156C2779243328 @default.
• W3017584156 hasConceptScore W3017584156C2781092759 @default.
• W3017584156 hasConceptScore W3017584156C41008148 @default.
• W3017584156 hasConceptScore W3017584156C503630168 @default.
• W3017584156 hasConceptScore W3017584156C54355233 @default.
• W3017584156 hasConceptScore W3017584156C55493867 @default.
• W3017584156 hasConceptScore W3017584156C59822182 @default.

• next