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- W3017597029 abstract "Background: Studies has shown that the prevalence and incidence of diabetes mellitus varies with type of diagnostic criteria used: fasting plasma glucose of ≥ 7 mmol/l or a two hours post prandial glucose of ≥ 11.1 mmol/l or a glycated haemoglobin of 6.5%. This mean that the sensitivity and specificity of these parameters may vary. Though the diagnostic criteria of FPG and 2HPPG is used independent of the other, the cost of these tests become important and significant with regards to choice in resource- constrained setting. Aim: This study is to compare the ability of FPG and 2HPPG diagnostic criteria in making a diagnosis of diabetes from oral glucose tolerance test (OGTT) results in this resource constrained locality. Methods: A retrospective study of OGTT results from the laboratory of a tertiary hospital in southern Nigeria. WHO criteria for diagnosing diabetes mellitus using FPG≥ 7mmol/l and/or a 2HPPG ≥ 11.1 mmol/l from each subject was compared for sensitivity, specificity and accuracy. This OGTT results were determined using the glucose oxidase method to evaluate plasma glucose. Results: 150 subjects were diagnosed diabetic when the FPG was used, while 160 subjects were diagnosed diabetic when 2HPPG parameter was used. Those that were simultaneously positive for both FPG and 2HPPG were 120 and were regarded as the true positives (TP) for the purpose of this study. The sensitivity of both FPG and 2HPPG were 58% and 67% respectively while the specificities were both 98%. Conclusion: From this study, it was noted that more subjects were diagnosed diabetic using the 2HPPG which also had a higher sensitivity and positive predictive value. Therefore, the use of 2HPPG should be encouraged for targeted screening of diabetes mellitus to reduce a false sense of security for those who may be misdiagnosed and FPG test used for mass screening of diabetes mellitus to save time." @default.
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- W3017597029 date "2020-01-01" @default.
- W3017597029 modified "2023-09-26" @default.
- W3017597029 title "Diagnosis of Diabetes Mellitus in a Resource-Constrained Setting: A Comparison of Fasting Plasma and Two Hours Post Prandial Glucose Values" @default.
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