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- W3017600963 abstract "Increase in the nitrogen (N)-use efficiency and optimization of N response in crop species are urgently needed. Although transcription factor-based genetic engineering is a promising approach for achieving these goals, transcription factors that play key roles in the response to N deficiency have not been studied extensively. Here, we performed RNA-seq analysis of root samples of 20 Asian rice (Oryza sativa) accessions with differential nutrient uptake. Data obtained from plants exposed to N-replete and N-deficient conditions were subjected to coexpression analysis and machine learning-based pathway inference to dissect the gene regulatory network required for the response to N deficiency. Four transcription factors, including members of the G2-like and bZIP families, were predicted to function as key regulators of gene transcription within the network in response to N deficiency. Cotransfection assays validated inferred novel regulatory pathways, and further analyses using genome-edited knockout lines suggested that these transcription factors are important for N-deficiency responses in planta. Many of the N deficiency-responsive genes, including those encoding key regulators within the network, were coordinately regulated by transcription factors belonging to different families. Transcription factors identified in this study could be valuable for the modification of N response and metabolism." @default.
- W3017600963 created "2020-05-01" @default.
- W3017600963 creator A5002916772 @default.
- W3017600963 creator A5006924123 @default.
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- W3017600963 creator A5055401085 @default.
- W3017600963 creator A5065227938 @default.
- W3017600963 creator A5077696016 @default.
- W3017600963 date "2020-05-29" @default.
- W3017600963 modified "2023-10-17" @default.
- W3017600963 title "Gene regulatory network and its constituent transcription factors that control nitrogen‐deficiency responses in rice" @default.
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