Matches in SemOpenAlex for { <https://semopenalex.org/work/W3017655345> ?p ?o ?g. }
- W3017655345 abstract "Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive and lethal interstitial lung disease characterized by consistent pulmonary inflammation. Although protein kinase C delta (PKCδ) is involved in broad scope cellular response, the role of PKCδ in IPF is complicated and has not been fully defined yet. Here, we reported that PKCδ deficiency (PKCδ-/-) aggravated bleomycin (BLM)-induced pulmonary fibrosis and inflammation. Upon challenge with BLM, the pulmonary capillary permeability, immune cell infiltration, inflammatory cytokine production, and collagen deposition were enhanced in PKCδ-/- mice compared to that in PKCδ+/+ mice. In response to poly(I:C) stimulation, PKCδ deficient macrophages displayed an increased production of IL-1β, IL-6, TNF-α, and IL-33, which were associated with an enhanced NF-κB activation. Furthermore, we found that PKCδ could directly bind to and phosphorylate A20, an inhibitory protein of NF-κB signal. These results suggested that PKCδ may inhibit the NF-κB signaling pathway via enhancing the stability and activity of A20, which in turn attenuates pulmonary fibrosis, suggesting that PKCδ is a promising target for treating pulmonary fibrosis." @default.
- W3017655345 created "2020-05-01" @default.
- W3017655345 creator A5008726894 @default.
- W3017655345 creator A5010607811 @default.
- W3017655345 creator A5024639292 @default.
- W3017655345 creator A5035701638 @default.
- W3017655345 creator A5042241049 @default.
- W3017655345 creator A5049387493 @default.
- W3017655345 creator A5051434149 @default.
- W3017655345 creator A5066886337 @default.
- W3017655345 creator A5068586842 @default.
- W3017655345 date "2020-04-22" @default.
- W3017655345 modified "2023-10-17" @default.
- W3017655345 title "Protein Kinase C δ (PKCδ) Attenuates Bleomycin Induced Pulmonary Fibrosis via Inhibiting NF-κB Signaling Pathway" @default.
- W3017655345 cites W1491701504 @default.
- W3017655345 cites W1530104357 @default.
- W3017655345 cites W1885503144 @default.
- W3017655345 cites W1913050826 @default.
- W3017655345 cites W1950305586 @default.
- W3017655345 cites W1966365711 @default.
- W3017655345 cites W1970722898 @default.
- W3017655345 cites W1973256540 @default.
- W3017655345 cites W1978800133 @default.
- W3017655345 cites W1980573760 @default.
- W3017655345 cites W1986178107 @default.
- W3017655345 cites W1990509075 @default.
- W3017655345 cites W1995747121 @default.
- W3017655345 cites W2000085856 @default.
- W3017655345 cites W2006928695 @default.
- W3017655345 cites W2007711402 @default.
- W3017655345 cites W2009114557 @default.
- W3017655345 cites W2011101614 @default.
- W3017655345 cites W2011236111 @default.
- W3017655345 cites W2018233812 @default.
- W3017655345 cites W2025923829 @default.
- W3017655345 cites W2034236127 @default.
- W3017655345 cites W2035312486 @default.
- W3017655345 cites W2036149026 @default.
- W3017655345 cites W2058065781 @default.
- W3017655345 cites W2070054912 @default.
- W3017655345 cites W2073856262 @default.
- W3017655345 cites W2075964458 @default.
- W3017655345 cites W2076649145 @default.
- W3017655345 cites W2079576820 @default.
- W3017655345 cites W2079872255 @default.
- W3017655345 cites W2080889523 @default.
- W3017655345 cites W2083793558 @default.
- W3017655345 cites W2085637098 @default.
- W3017655345 cites W2085870660 @default.
- W3017655345 cites W2093881154 @default.
- W3017655345 cites W2110583109 @default.
- W3017655345 cites W2117905385 @default.
- W3017655345 cites W2118901290 @default.
- W3017655345 cites W2125577882 @default.
- W3017655345 cites W2134940821 @default.
- W3017655345 cites W2140916429 @default.
- W3017655345 cites W2158668670 @default.
- W3017655345 cites W2164881817 @default.
- W3017655345 cites W2191666140 @default.
- W3017655345 cites W2301044272 @default.
- W3017655345 cites W2468567807 @default.
- W3017655345 cites W2521483984 @default.
- W3017655345 cites W2570109500 @default.
- W3017655345 cites W2573628710 @default.
- W3017655345 cites W2580451638 @default.
- W3017655345 cites W2611560826 @default.
- W3017655345 cites W2616395876 @default.
- W3017655345 cites W2746187103 @default.
- W3017655345 cites W2767139385 @default.
- W3017655345 cites W2770262779 @default.
- W3017655345 cites W2790240574 @default.
- W3017655345 cites W2791214769 @default.
- W3017655345 cites W2791676985 @default.
- W3017655345 cites W2792764089 @default.
- W3017655345 cites W2804480350 @default.
- W3017655345 cites W2804549148 @default.
- W3017655345 cites W2891152891 @default.
- W3017655345 cites W2904077699 @default.
- W3017655345 cites W2935954941 @default.
- W3017655345 cites W2954900551 @default.
- W3017655345 cites W296319558 @default.
- W3017655345 cites W2980546523 @default.
- W3017655345 cites W4234012993 @default.
- W3017655345 cites W4250290305 @default.
- W3017655345 doi "https://doi.org/10.3389/fphys.2020.00367" @default.
- W3017655345 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7188947" @default.
- W3017655345 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32390869" @default.
- W3017655345 hasPublicationYear "2020" @default.
- W3017655345 type Work @default.
- W3017655345 sameAs 3017655345 @default.
- W3017655345 citedByCount "13" @default.
- W3017655345 countsByYear W30176553452021 @default.
- W3017655345 countsByYear W30176553452022 @default.
- W3017655345 countsByYear W30176553452023 @default.
- W3017655345 crossrefType "journal-article" @default.
- W3017655345 hasAuthorship W3017655345A5008726894 @default.
- W3017655345 hasAuthorship W3017655345A5010607811 @default.
- W3017655345 hasAuthorship W3017655345A5024639292 @default.
- W3017655345 hasAuthorship W3017655345A5035701638 @default.
- W3017655345 hasAuthorship W3017655345A5042241049 @default.