FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3017700713> ?p ?o ?g. }

• W3017700713 endingPage "1934578X2092048" @default.
• W3017700713 startingPage "1934578X2092048" @default.
• W3017700713 abstract "Recently, additional therapeutic potentials of classical antibiotics are gaining considerable attention. The discovery of penicillin in the 1920s had a major impact on the history of human health. Penicillin has been used for the treatment for fatal microbial infections in humans and has led to the discovery of several new antibiotics. d-(+)-Cycloserine (DCS) is an antibiotic isolated from Streptomyces orchidaceous and is used in conjunction with other drugs in the treatment of tuberculosis. However, there have been no studies on the anti-inflammatory effects of DCS in RAW 264.7 macrophage cell line. To investigate the anti-inflammatory effects of DCS, we examined the ability of DCS to inhibit the inflammatory responses in lipopolysaccharide (LPS)-induced RAW 264.7 macrophages in this study. Cell viability was analyzed using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. The cells were pretreated with various concentrations (2, 4, and 6 mM) of DCS, then treated with 1 μg/mL LPS to detect its anti-inflammatory effects. d-(+)-Cycloserine inhibited the production of nitric oxide (NO) in a concentration-dependent manner, and to some extent, inhibited the production of prostaglandin E 2 . Consistent with these findings, DCS suppressed the expression of pro-inflammatory cytokines such as interleukin (IL)-1β and IL-6. However, it had no effect on the expression of tumor necrosis factor-α. Western blot analysis demonstrated that DCS inhibited inducible nitric oxide synthase and suppressed cyclooxygenase type-2 (COX-2) expression. In addition, investigation of its effects on nuclear factor kappa B signaling showed that DCS inhibited phosphorylation of inhibitory kappa B-α (IκB-α) and increased intracellular IκB-α in a concentration-dependent manner. Furthermore, DCS inhibited the phosphorylation of LPS-induced extracellular signal-regulated kinase, however it did not affect phosphorylation of c-jun N-terminal kinase and p38. Further studies confirmed that the inhibition of phosphorylation of IκB-α was mediated through the inhibition of phosphoinositide 3-kinase/Akt (PI3K/Akt) pathway. To determine the applicability of DCS to the skin, cytotoxicity on HaCaT keratinocytes was measured following treatment with various concentrations (2, 4, 6, 8, and 10 mM) of DCS using MTT assay. These results suggest that DCS may be used as a potential drug for the treatment of inflammatory diseases." @default.
• W3017700713 created "2020-05-01" @default.
• W3017700713 creator A5019761462 @default.
• W3017700713 creator A5047819039 @default.
• W3017700713 date "2020-04-01" @default.
• W3017700713 modified "2023-10-16" @default.
• W3017700713 title "Anti-inflammatory Effect of d-(+)-Cycloserine Through Inhibition of NF-κB and MAPK Signaling Pathways in LPS-Induced RAW 264.7 Macrophages" @default.
• W3017700713 cites W1126381461 @default.
• W3017700713 cites W1536033096 @default.
• W3017700713 cites W1577949359 @default.
• W3017700713 cites W1947791771 @default.
• W3017700713 cites W1985953874 @default.
• W3017700713 cites W1988255391 @default.
• W3017700713 cites W1990381196 @default.
• W3017700713 cites W1994168958 @default.
• W3017700713 cites W2001623063 @default.
• W3017700713 cites W2008039800 @default.
• W3017700713 cites W2010417491 @default.
• W3017700713 cites W2019795889 @default.
• W3017700713 cites W2024322742 @default.
• W3017700713 cites W2036603858 @default.
• W3017700713 cites W2041871330 @default.
• W3017700713 cites W2046975355 @default.
• W3017700713 cites W2056821401 @default.
• W3017700713 cites W2062835892 @default.
• W3017700713 cites W2066171146 @default.
• W3017700713 cites W2067649855 @default.
• W3017700713 cites W2080783630 @default.
• W3017700713 cites W2081274536 @default.
• W3017700713 cites W2082139548 @default.
• W3017700713 cites W2091053479 @default.
• W3017700713 cites W2093073024 @default.
• W3017700713 cites W2156761302 @default.
• W3017700713 cites W2169322299 @default.
• W3017700713 cites W2169405258 @default.
• W3017700713 cites W2289517083 @default.
• W3017700713 cites W2765732544 @default.
• W3017700713 cites W2765737057 @default.
• W3017700713 cites W2782555529 @default.
• W3017700713 cites W2900771627 @default.
• W3017700713 cites W2901257350 @default.
• W3017700713 cites W2901527348 @default.
• W3017700713 cites W2920443386 @default.
• W3017700713 cites W2946984128 @default.
• W3017700713 cites W2951600526 @default.
• W3017700713 cites W2979798808 @default.
• W3017700713 cites W4245868295 @default.
• W3017700713 doi "https://doi.org/10.1177/1934578x20920481" @default.
• W3017700713 hasPublicationYear "2020" @default.
• W3017700713 type Work @default.
• W3017700713 sameAs 3017700713 @default.
• W3017700713 citedByCount "7" @default.
• W3017700713 countsByYear W30177007132020 @default.
• W3017700713 countsByYear W30177007132021 @default.
• W3017700713 countsByYear W30177007132022 @default.
• W3017700713 countsByYear W30177007132023 @default.
• W3017700713 crossrefType "journal-article" @default.
• W3017700713 hasAuthorship W3017700713A5019761462 @default.
• W3017700713 hasAuthorship W3017700713A5047819039 @default.
• W3017700713 hasBestOaLocation W30177007131 @default.
• W3017700713 hasConcept C104317684 @default.
• W3017700713 hasConcept C1491633281 @default.
• W3017700713 hasConcept C178790620 @default.
• W3017700713 hasConcept C17991360 @default.
• W3017700713 hasConcept C185592680 @default.
• W3017700713 hasConcept C203014093 @default.
• W3017700713 hasConcept C2776415932 @default.
• W3017700713 hasConcept C2777622882 @default.
• W3017700713 hasConcept C2778754761 @default.
• W3017700713 hasConcept C519581460 @default.
• W3017700713 hasConcept C53227056 @default.
• W3017700713 hasConcept C55493867 @default.
• W3017700713 hasConcept C86803240 @default.
• W3017700713 hasConcept C89423630 @default.
• W3017700713 hasConcept C98274493 @default.
• W3017700713 hasConceptScore W3017700713C104317684 @default.
• W3017700713 hasConceptScore W3017700713C1491633281 @default.
• W3017700713 hasConceptScore W3017700713C178790620 @default.
• W3017700713 hasConceptScore W3017700713C17991360 @default.
• W3017700713 hasConceptScore W3017700713C185592680 @default.
• W3017700713 hasConceptScore W3017700713C203014093 @default.
• W3017700713 hasConceptScore W3017700713C2776415932 @default.
• W3017700713 hasConceptScore W3017700713C2777622882 @default.
• W3017700713 hasConceptScore W3017700713C2778754761 @default.
• W3017700713 hasConceptScore W3017700713C519581460 @default.
• W3017700713 hasConceptScore W3017700713C53227056 @default.
• W3017700713 hasConceptScore W3017700713C55493867 @default.
• W3017700713 hasConceptScore W3017700713C86803240 @default.
• W3017700713 hasConceptScore W3017700713C89423630 @default.
• W3017700713 hasConceptScore W3017700713C98274493 @default.
• W3017700713 hasIssue "4" @default.
• W3017700713 hasLocation W30177007131 @default.
• W3017700713 hasOpenAccess W3017700713 @default.
• W3017700713 hasPrimaryLocation W30177007131 @default.
• W3017700713 hasRelatedWork W1971526531 @default.
• W3017700713 hasRelatedWork W1985855187 @default.
• W3017700713 hasRelatedWork W1986555336 @default.
• W3017700713 hasRelatedWork W2010868322 @default.

• next