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- W3017776224 abstract "Eosinophilic pneumonia (EP), including acute EP and chronic EP, is characterized by the massive pulmonary infiltration of eosinophils into the lung. However, the mechanisms underlying the selective accumulation of eosinophils in EP have not yet been fully elucidated. We reported that bronchoalveolar lavage fluid (BALF) from EP patients induced the transmigration of eosinophils across endothelial cells in vitro. The concentrations of eotaxin-2 (CCL24) and monocyte chemotactic protein (MCP)-4 (CCL13), which are CC chemokine receptor (CCR) 3 ligands, were elevated in the BALF of EP patients, and anti-CCR3 monoclonal antibody inhibited the eosinophil transmigration induced by the BALF of EP patients. The concentration of macrophage inflammatory protein 1β (CCL4), a CCR5 ligand that induces eosinophil migration, was increased in the BALF of EP patients. Furthermore, the concentration of interleukin (IL) 5 was increased in the BALF of EP patients, and it has been reported that anti-IL-5 antibody treatment resulted in remission and the reduction of glucocorticoid use in some cases of chronic EP. The concentrations of lipid mediators, such as leukotriene (LT) B4, damage-associated molecular pattern molecules (DAMPs), such as uric acid, or extracellular matrix proteins, such as periostin, were also increased in the BALF of EP patients. These findings suggest that chemokines, such as CCR3/CCR5 ligands, cytokines, such as IL-5, lipid mediators, such as LTB4, DAMPs, and extracellular matrix proteins may play roles in the accumulation or activation of eosinophils in EP." @default.
- W3017776224 created "2020-05-01" @default.
- W3017776224 creator A5057313515 @default.
- W3017776224 creator A5081937545 @default.
- W3017776224 date "2020-04-21" @default.
- W3017776224 modified "2023-10-14" @default.
- W3017776224 title "Possible Mechanisms of Eosinophil Accumulation in Eosinophilic Pneumonia" @default.
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- W3017776224 doi "https://doi.org/10.3390/biom10040638" @default.
- W3017776224 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7226607" @default.
- W3017776224 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32326200" @default.
- W3017776224 hasPublicationYear "2020" @default.
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