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- W301777778 abstract "This chapter describes novel approaches and formulations in the delivery of biologics to the central nervous system (CNS). We begin by discussing the increasing global burden of CNS disorders as well as providing an overview of the current market share of pharmaceuticals for CNS indications. We then briefly review the structure and function of the blood–brain barrier (BBB) and discuss a market survey of U.S. Food and Drug Administration (FDA)-approved CNS drugs, followed by a review of the current clinically available strategies, both physical and chemical, for overcoming the BBB. We conclude by discussing recently developed directions in CNS delivery of biologics that rely on natural transport pathways, vector-mediated delivery systems, stem cells, and nanomaterials." @default.
- W301777778 created "2016-06-24" @default.
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- W301777778 date "2015-01-01" @default.
- W301777778 modified "2023-10-14" @default.
- W301777778 title "Novel Approaches for the Delivery of Biologics to the Central Nervous System" @default.
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- W301777778 doi "https://doi.org/10.1016/b978-0-12-416603-5.00004-3" @default.
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