FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3017830108> ?p ?o ?g. }

• W3017830108 endingPage "643" @default.
• W3017830108 startingPage "643" @default.
• W3017830108 abstract "Immunogenic cell death (ICD) refers to a unique form of cell death that activates an adaptive immune response against dead-cell-associated antigens. Accumulating evidence indicates that the efficacy of conventional anticancer agents relies on not only their direct cytostatic/cytotoxic effects but also the activation of antitumor ICD. Common anticancer ICD inducers include certain chemotherapeutic agents (such as anthracyclines, oxaliplatin, and bortezomib), radiotherapy, photodynamic therapy (PDT), and oncolytic virotherapies. However, most chemotherapeutic reagents are inefficient or fail to trigger ICD. Therefore, better understanding on the molecular determinants of chemotherapy-induced ICD will help in the development of more efficient combinational anticancer strategies through converting non- or relatively weak ICD inducers into bona fide ICD inducers. In this study, we found that sequential, but not concurrent, treatment of cancer cells with interferon β (IFNβ), a type I IFN, and cisplatin (an inefficient ICD inducer) can enhance the expression of ICD biomarkers in cancer cells, including surface translocation of an endoplasmic reticulum (ER) chaperone, calreticulin (CRT), and phosphorylation of the eukaryotic translation initiation factor alpha (eIF2α). These results suggest that exogenous IFNβ may activate molecular determinants that convert cisplatin into an ICD inducer. Further bioinformatics and in vitro experimental analyses found that interferon regulatory factor 1 (IRF1) acted as an essential mediator of surface CRT exposure by sequential IFNβ-cisplatin combination. Our findings not only help to design more effective combinational anticancer therapy using IFNβ and cisplatin, but also provide a novel insight into the role of IRF1 in connecting the type I IFN responses and ICD." @default.
• W3017830108 created "2020-05-01" @default.
• W3017830108 creator A5007435688 @default.
• W3017830108 creator A5034407820 @default.
• W3017830108 creator A5043358331 @default.
• W3017830108 creator A5062803843 @default.
• W3017830108 creator A5080902707 @default.
• W3017830108 date "2020-04-21" @default.
• W3017830108 modified "2023-10-03" @default.
• W3017830108 title "Sequential Interferon β-Cisplatin Treatment Enhances the Surface Exposure of Calreticulin in Cancer Cells via an Interferon Regulatory Factor 1-Dependent Manner" @default.
• W3017830108 cites W1911271782 @default.
• W3017830108 cites W1942176190 @default.
• W3017830108 cites W1967329857 @default.
• W3017830108 cites W1970403122 @default.
• W3017830108 cites W1971254854 @default.
• W3017830108 cites W1979908884 @default.
• W3017830108 cites W1982935652 @default.
• W3017830108 cites W1983623971 @default.
• W3017830108 cites W1988325794 @default.
• W3017830108 cites W1991189794 @default.
• W3017830108 cites W1997062395 @default.
• W3017830108 cites W1999998145 @default.
• W3017830108 cites W2000175632 @default.
• W3017830108 cites W2000177767 @default.
• W3017830108 cites W2003801865 @default.
• W3017830108 cites W2016612145 @default.
• W3017830108 cites W2025483501 @default.
• W3017830108 cites W2028297274 @default.
• W3017830108 cites W2033417996 @default.
• W3017830108 cites W2051361539 @default.
• W3017830108 cites W2057714372 @default.
• W3017830108 cites W2059384319 @default.
• W3017830108 cites W2081796577 @default.
• W3017830108 cites W2085190762 @default.
• W3017830108 cites W2090750060 @default.
• W3017830108 cites W2091103707 @default.
• W3017830108 cites W2093424661 @default.
• W3017830108 cites W2096173332 @default.
• W3017830108 cites W2101595088 @default.
• W3017830108 cites W2114790501 @default.
• W3017830108 cites W2118258530 @default.
• W3017830108 cites W2123106337 @default.
• W3017830108 cites W2130153302 @default.
• W3017830108 cites W2130410032 @default.
• W3017830108 cites W2139154967 @default.
• W3017830108 cites W2141037581 @default.
• W3017830108 cites W2142153200 @default.
• W3017830108 cites W2147389335 @default.
• W3017830108 cites W2163252162 @default.
• W3017830108 cites W2166291558 @default.
• W3017830108 cites W2166937531 @default.
• W3017830108 cites W2170245529 @default.
• W3017830108 cites W2171249989 @default.
• W3017830108 cites W2210453860 @default.
• W3017830108 cites W2214074259 @default.
• W3017830108 cites W2320177900 @default.
• W3017830108 cites W2339527241 @default.
• W3017830108 cites W2343700125 @default.
• W3017830108 cites W2397222906 @default.
• W3017830108 cites W2398665740 @default.
• W3017830108 cites W2536322725 @default.
• W3017830108 cites W2595092778 @default.
• W3017830108 cites W2784314693 @default.
• W3017830108 cites W2800160879 @default.
• W3017830108 cites W2900569176 @default.
• W3017830108 cites W2901550388 @default.
• W3017830108 cites W2912593436 @default.
• W3017830108 cites W2995643185 @default.
• W3017830108 doi "https://doi.org/10.3390/biom10040643" @default.
• W3017830108 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7226424" @default.
• W3017830108 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32326356" @default.
• W3017830108 hasPublicationYear "2020" @default.
• W3017830108 type Work @default.
• W3017830108 sameAs 3017830108 @default.
• W3017830108 citedByCount "20" @default.
• W3017830108 countsByYear W30178301082020 @default.
• W3017830108 countsByYear W30178301082021 @default.
• W3017830108 countsByYear W30178301082022 @default.
• W3017830108 countsByYear W30178301082023 @default.
• W3017830108 crossrefType "journal-article" @default.
• W3017830108 hasAuthorship W3017830108A5007435688 @default.
• W3017830108 hasAuthorship W3017830108A5034407820 @default.
• W3017830108 hasAuthorship W3017830108A5043358331 @default.
• W3017830108 hasAuthorship W3017830108A5062803843 @default.
• W3017830108 hasAuthorship W3017830108A5080902707 @default.
• W3017830108 hasBestOaLocation W30178301081 @default.
• W3017830108 hasConcept C104317684 @default.
• W3017830108 hasConcept C121608353 @default.
• W3017830108 hasConcept C158617107 @default.
• W3017830108 hasConcept C203014093 @default.
• W3017830108 hasConcept C2776178377 @default.
• W3017830108 hasConcept C2776694085 @default.
• W3017830108 hasConcept C2777877232 @default.
• W3017830108 hasConcept C2778239845 @default.
• W3017830108 hasConcept C3020616263 @default.
• W3017830108 hasConcept C32300475 @default.
• W3017830108 hasConcept C47450691 @default.
• W3017830108 hasConcept C502942594 @default.

• next