Matches in SemOpenAlex for { <https://semopenalex.org/work/W3017903966> ?p ?o ?g. }
- W3017903966 endingPage "2002" @default.
- W3017903966 startingPage "1994" @default.
- W3017903966 abstract "Cocaine addiction is a chronic illness characterized by maladaptive drug-induced neuroplastic changes that confer lasting vulnerability to relapse. Over several weeks we observed the effects of the M1 receptor-selective agonist VU0364572 in adult male rats that self-administer cocaine in a cocaine vs. food choice procedure. The drug showed unusual long-lasting effects, as rats gradually stopped self-administering cocaine, reallocating behavior towards the food reinforcer. The effect lasted as long as tested and at least 4 weeks. To begin to elucidate how VU0364572 modulates cocaine self-administration, we then examined its long-term effects using dual-probe in vivo dopamine and glutamate microdialysis in nucleus accumbens and medial prefrontal cortex, and ex vivo striatal dopamine reuptake. Microdialysis revealed marked decreases in cocaine-induced dopamine and glutamate outflow 4 weeks after VU0364572 treatment, without significant changes in dopamine uptake function. These lasting and marked effects of M1 receptor stimulation reinforce our interest in this target as potential treatment of cocaine addiction. M1 receptors are known to modulate medium spiny neuron responses to corticostriatal glutamatergic signaling acutely, and we hypothesize that VU0364572 may oppose the addiction-related effects of cocaine by causing lasting changes in this system." @default.
- W3017903966 created "2020-05-01" @default.
- W3017903966 creator A5013981616 @default.
- W3017903966 creator A5031395961 @default.
- W3017903966 creator A5083833114 @default.
- W3017903966 date "2020-04-28" @default.
- W3017903966 modified "2023-10-18" @default.
- W3017903966 title "Effects of muscarinic M1 receptor stimulation on reinforcing and neurochemical effects of cocaine in rats" @default.
- W3017903966 cites W1543271211 @default.
- W3017903966 cites W1776364276 @default.
- W3017903966 cites W1823260965 @default.
- W3017903966 cites W1874938414 @default.
- W3017903966 cites W1889428062 @default.
- W3017903966 cites W1916293712 @default.
- W3017903966 cites W1967292256 @default.
- W3017903966 cites W1976323601 @default.
- W3017903966 cites W1976864358 @default.
- W3017903966 cites W1981762957 @default.
- W3017903966 cites W1984727326 @default.
- W3017903966 cites W1987996701 @default.
- W3017903966 cites W1997065612 @default.
- W3017903966 cites W1998777125 @default.
- W3017903966 cites W2000825098 @default.
- W3017903966 cites W2006518174 @default.
- W3017903966 cites W2008702443 @default.
- W3017903966 cites W2014127226 @default.
- W3017903966 cites W2016232482 @default.
- W3017903966 cites W2020245525 @default.
- W3017903966 cites W2021594631 @default.
- W3017903966 cites W2023455262 @default.
- W3017903966 cites W2025170140 @default.
- W3017903966 cites W2030612633 @default.
- W3017903966 cites W2032228733 @default.
- W3017903966 cites W2034322646 @default.
- W3017903966 cites W2035636882 @default.
- W3017903966 cites W2035721067 @default.
- W3017903966 cites W2037255773 @default.
- W3017903966 cites W2041858605 @default.
- W3017903966 cites W2042148521 @default.
- W3017903966 cites W2043496808 @default.
- W3017903966 cites W2046185031 @default.
- W3017903966 cites W2048255799 @default.
- W3017903966 cites W2057089006 @default.
- W3017903966 cites W2077763205 @default.
- W3017903966 cites W2078530990 @default.
- W3017903966 cites W2078584968 @default.
- W3017903966 cites W2085430427 @default.
- W3017903966 cites W2085465429 @default.
- W3017903966 cites W2103057436 @default.
- W3017903966 cites W2106719141 @default.
- W3017903966 cites W2108168723 @default.
- W3017903966 cites W2110405906 @default.
- W3017903966 cites W2112824246 @default.
- W3017903966 cites W2135090757 @default.
- W3017903966 cites W2136267239 @default.
- W3017903966 cites W2154850432 @default.
- W3017903966 cites W2156023315 @default.
- W3017903966 cites W2171464354 @default.
- W3017903966 cites W2174927484 @default.
- W3017903966 cites W2278823400 @default.
- W3017903966 cites W2328543694 @default.
- W3017903966 cites W2345672368 @default.
- W3017903966 cites W2414103203 @default.
- W3017903966 cites W2460802970 @default.
- W3017903966 cites W2490270569 @default.
- W3017903966 cites W2491859250 @default.
- W3017903966 cites W2561153484 @default.
- W3017903966 cites W2589774909 @default.
- W3017903966 cites W2590245649 @default.
- W3017903966 cites W2603378790 @default.
- W3017903966 cites W2611268510 @default.
- W3017903966 cites W2622234382 @default.
- W3017903966 cites W2728852205 @default.
- W3017903966 cites W2760657087 @default.
- W3017903966 cites W2771701431 @default.
- W3017903966 cites W2791870770 @default.
- W3017903966 cites W2801645749 @default.
- W3017903966 cites W2805882949 @default.
- W3017903966 cites W2900630721 @default.
- W3017903966 cites W2936554496 @default.
- W3017903966 cites W4246659915 @default.
- W3017903966 doi "https://doi.org/10.1038/s41386-020-0684-1" @default.
- W3017903966 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7547714" @default.
- W3017903966 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32344426" @default.
- W3017903966 hasPublicationYear "2020" @default.
- W3017903966 type Work @default.
- W3017903966 sameAs 3017903966 @default.
- W3017903966 citedByCount "8" @default.
- W3017903966 countsByYear W30179039662020 @default.
- W3017903966 countsByYear W30179039662021 @default.
- W3017903966 countsByYear W30179039662022 @default.
- W3017903966 countsByYear W30179039662023 @default.
- W3017903966 crossrefType "journal-article" @default.
- W3017903966 hasAuthorship W3017903966A5013981616 @default.
- W3017903966 hasAuthorship W3017903966A5031395961 @default.
- W3017903966 hasAuthorship W3017903966A5083833114 @default.
- W3017903966 hasBestOaLocation W30179039661 @default.
- W3017903966 hasConcept C120069818 @default.