FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3017936963> ?p ?o ?g. }

• W3017936963 abstract "Abstract Background Antibiotics are commonly prescribed to treat chronic rhinosinusitis (CRS); however, the effects of antibiotics on the microbiome and secreted proteome remain unknown in regard to CRS. Objective We analyzed the effects of antibiotics on the nasal microbiome and secreted proteome in the context of CRS using multi-omic analysis. Methods Nasal secretions were collected from 29 control, 30 CRS patients without nasal polyps (CRSsNP), and 40 CRS patients with nasal polyps (CRSwNP). A total of 99 subjects were divided into two groups that included subjects who had taken antibiotics 3 months prior to sampling (ABX) and those who had not (NABX). We performed 16S rDNA sequence analyses and Orbitrap mass spectrometry-based proteomic analyses in data-independent acquisition (DIA) on the nasal secretions. Spearman correlation was used to assess the correlations between the nasal microbiome and secreted proteome. Results We observed a strong association between the nasal microbiome and secreted proteome according to disease status. Antibiotic use reduced differences in the microbial community and secreted proteome according to disease status. Interestingly, in nasal polyp (NP) patients, antibiotics exhibited strong effects not only on the nasal microbiome and the secreted proteome but also on their associations. Additionally, their correlations were strengthened in subjects who had taken antibiotics. Conclusion Integrative analyses revealed that the correlations between the microbiome and the secreted proteome could be altered and strengthened in subjects who used antibiotics. These findings provide novel insight into the effects of antibiotics on the nasal environment and the host responses in CRS." @default.
• W3017936963 created "2020-05-01" @default.
• W3017936963 creator A5020947737 @default.
• W3017936963 creator A5038577249 @default.
• W3017936963 creator A5050299530 @default.
• W3017936963 creator A5062719181 @default.
• W3017936963 creator A5085357988 @default.
• W3017936963 creator A5085995979 @default.
• W3017936963 creator A5089590792 @default.
• W3017936963 creator A5091660120 @default.
• W3017936963 date "2020-04-28" @default.
• W3017936963 modified "2023-09-29" @default.
• W3017936963 title "Antibiotic-dependent relationships between nasal microbiome and secreted proteome in chronic rhinosinusitis and nasal polyps" @default.
• W3017936963 cites W1552495850 @default.
• W3017936963 cites W2034285706 @default.
• W3017936963 cites W2034597714 @default.
• W3017936963 cites W2036321220 @default.
• W3017936963 cites W2056279562 @default.
• W3017936963 cites W2062143232 @default.
• W3017936963 cites W2062859898 @default.
• W3017936963 cites W2065578333 @default.
• W3017936963 cites W2072970694 @default.
• W3017936963 cites W2086268256 @default.
• W3017936963 cites W2093734206 @default.
• W3017936963 cites W2099842492 @default.
• W3017936963 cites W2124351063 @default.
• W3017936963 cites W2126608122 @default.
• W3017936963 cites W2130132002 @default.
• W3017936963 cites W2133053842 @default.
• W3017936963 cites W2133856765 @default.
• W3017936963 cites W2137574477 @default.
• W3017936963 cites W2155540159 @default.
• W3017936963 cites W2289316671 @default.
• W3017936963 cites W2319967189 @default.
• W3017936963 cites W2463195069 @default.
• W3017936963 cites W2521634925 @default.
• W3017936963 cites W2523270036 @default.
• W3017936963 cites W2544360569 @default.
• W3017936963 cites W2554506152 @default.
• W3017936963 cites W2566953609 @default.
• W3017936963 cites W2581250649 @default.
• W3017936963 cites W2586021575 @default.
• W3017936963 cites W2612824952 @default.
• W3017936963 cites W2613603843 @default.
• W3017936963 cites W2736294284 @default.
• W3017936963 cites W2761846098 @default.
• W3017936963 cites W2775193936 @default.
• W3017936963 cites W2783845858 @default.
• W3017936963 cites W2785751243 @default.
• W3017936963 cites W2789156667 @default.
• W3017936963 cites W2801973370 @default.
• W3017936963 cites W2804929732 @default.
• W3017936963 cites W2810764565 @default.
• W3017936963 cites W2897558112 @default.
• W3017936963 cites W2904849668 @default.
• W3017936963 cites W2904987851 @default.
• W3017936963 cites W2911230579 @default.
• W3017936963 cites W2913529818 @default.
• W3017936963 cites W2921872958 @default.
• W3017936963 cites W2947189704 @default.
• W3017936963 cites W2948355575 @default.
• W3017936963 cites W2949728293 @default.
• W3017936963 cites W2964261376 @default.
• W3017936963 cites W3005054303 @default.
• W3017936963 cites W3183099619 @default.
• W3017936963 cites W755088251 @default.
• W3017936963 doi "https://doi.org/10.1101/2020.04.26.060764" @default.
• W3017936963 hasPublicationYear "2020" @default.
• W3017936963 type Work @default.
• W3017936963 sameAs 3017936963 @default.
• W3017936963 citedByCount "0" @default.
• W3017936963 crossrefType "posted-content" @default.
• W3017936963 hasAuthorship W3017936963A5020947737 @default.
• W3017936963 hasAuthorship W3017936963A5038577249 @default.
• W3017936963 hasAuthorship W3017936963A5050299530 @default.
• W3017936963 hasAuthorship W3017936963A5062719181 @default.
• W3017936963 hasAuthorship W3017936963A5085357988 @default.
• W3017936963 hasAuthorship W3017936963A5085995979 @default.
• W3017936963 hasAuthorship W3017936963A5089590792 @default.
• W3017936963 hasAuthorship W3017936963A5091660120 @default.
• W3017936963 hasBestOaLocation W30179369631 @default.
• W3017936963 hasConcept C104397665 @default.
• W3017936963 hasConcept C143121216 @default.
• W3017936963 hasConcept C203014093 @default.
• W3017936963 hasConcept C2777768476 @default.
• W3017936963 hasConcept C2781390199 @default.
• W3017936963 hasConcept C3019717275 @default.
• W3017936963 hasConcept C501593827 @default.
• W3017936963 hasConcept C59377437 @default.
• W3017936963 hasConcept C60644358 @default.
• W3017936963 hasConcept C71924100 @default.
• W3017936963 hasConcept C86803240 @default.
• W3017936963 hasConcept C89423630 @default.
• W3017936963 hasConceptScore W3017936963C104397665 @default.
• W3017936963 hasConceptScore W3017936963C143121216 @default.
• W3017936963 hasConceptScore W3017936963C203014093 @default.
• W3017936963 hasConceptScore W3017936963C2777768476 @default.
• W3017936963 hasConceptScore W3017936963C2781390199 @default.
• W3017936963 hasConceptScore W3017936963C3019717275 @default.
• W3017936963 hasConceptScore W3017936963C501593827 @default.

• next