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- W3017962010 abstract "IL-36R signaling plays an important role in the pathogenesis of psoriasis. We ought to assess the specific function of IL-36R in keratinocytes for the pathology of Aldara-induced psoriasis-like dermatitis. Il36r ΔK mice presenting deletion of IL-36R in keratinocytes were similarly resistant to Aldara-induced ear inflammation as Il36r −/− mice, but acanthosis was only prevented in Il36r −/− mice. FACS analysis revealed that IL-36R signaling in keratinocytes is mandatory for early neutrophil infiltration in Aldara-treated ears. RNASeq and qRT-PCR experiments demonstrated the crucial role of IL-36R signaling in keratinocytes for induction of IL-23, IL-17, and IL-22 at early time points. Taken together, our results demonstrate that IL-36R signaling in keratinocytes plays a major role in the induction of Aldara-induced psoriasis-like dermatitis by triggering early production of IL-23/IL-17/IL-22 cytokines and neutrophil infiltration." @default.
- W3017962010 created "2020-05-01" @default.
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- W3017962010 date "2020-04-28" @default.
- W3017962010 modified "2023-10-10" @default.
- W3017962010 title "IL-36 signaling in keratinocytes controls early IL-23 production in psoriasis-like dermatitis" @default.
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- W3017962010 doi "https://doi.org/10.26508/lsa.202000688" @default.
- W3017962010 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7190273" @default.
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