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• W3017992007 abstract "Abstract Previous studies have found that the primary pathogenesis of liver cancer progression is linked to excessive cancer cell proliferation and rapid metastasis. Although therapeutic advances have been made for the treatment of liver cancer, the mechanism underlying the liver cancer progression has not been fully addressed. In the present study, we explored the role of spliced X‐box binding protein 1 (XBP1) in regulating the viability and death of liver cancer cells in vitro. Our study demonstrated that XBP1 was upregulated in liver cancer cells when compared to the primary hepatocytes. Interestingly, the deletion of XBP1 could reduce the viability of liver cancer cells in vitro via inducing apoptotic response. Further, we found that XBP1 downregulation was also linked to proliferation arrest and migration inhibition. At the molecular levels, XBP1 inhibition is followed by activation of the Mst1 pathway which promoted the phosphorylation of c‐Jun N‐terminal kinase (JNK). Then, the active Mst1‐JNK pathway mediated mitochondrial reactive oxygen species (mROS) overproduction and then excessive ROS induced cancer cell death. Therefore, our study demonstrated a novel role played by XBP1 in modulating the viability of liver cancer cells via the Mst1‐JNK‐mROS pathways." @default.
• W3017992007 created "2020-05-01" @default.
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• W3017992007 date "2020-04-26" @default.
• W3017992007 modified "2023-09-23" @default.
• W3017992007 title "Spliced X‐box binding protein 1 induces liver cancer cell death via activating the Mst1‐JNK‐mROS signalling pathway" @default.
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• W3017992007 cites W2766354075 @default.
• W3017992007 cites W2766924760 @default.
• W3017992007 cites W2767847390 @default.
• W3017992007 cites W2768194723 @default.
• W3017992007 cites W2768752546 @default.
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• W3017992007 cites W2783371345 @default.
• W3017992007 cites W2783611772 @default.
• W3017992007 cites W2784251793 @default.
• W3017992007 cites W2790919646 @default.
• W3017992007 cites W2790957310 @default.
• W3017992007 cites W2791010363 @default.
• W3017992007 cites W2791414150 @default.
• W3017992007 cites W2791861468 @default.
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• W3017992007 cites W2793634709 @default.
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• W3017992007 doi "https://doi.org/10.1002/jcp.29742" @default.
• W3017992007 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32335916" @default.
• W3017992007 hasPublicationYear "2020" @default.
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