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• W3018032995 startingPage "105976" @default.
• W3018032995 abstract "• Photodynamic inactivation (PDI) is a promising approach to antimicrobial resistance • The efficacy of PDI is limited, particularly in Gram-negative bacteria • Tetrahydroporphyrin-tetratosylate (THPTS)-based PDI has led to promising results • The effects of THPTS-based PDI in a variety of multidrug-resistant bacteria are explored • The feasibility of light-emitting diode (LED) light application for THPS-based PDI is explored Photodynamic inactivation (PDI) is a promising approach to treat multidrug-resistant infections. However, effectiveness of PDI is limited, particularly in Gram-negative bacteria. The use of photosensitizer (PS) 3,3′,3′′,3′′′-(7,8,17,18-tetrahydro-21H,23H-porphyrine-5,10,15,20-tetrayl)tetrakis[1-methyl-pyridinium]tetratosylate (THPTS) and laser light has led to very promising results. This study focuses on the effects of THPTS in various critical multidrug-resistant bacterial strains and explores the possibility of light-emitting diode (LED)-based activation as a clinically more feasible alternative to laser light. THPTS was further chemically characterized and in vitro testing of PDI of different multidrug-resistant bacterial strains was performed under various experimental conditions, including varying drug concentration, incubation time, light source (laser and LED) and light intensity, by determination of viable bacteria after treatment. The effect of hyaluronic acid as an adjuvant for medical applications was also evaluated. Bacterial density of all investigated bacterial strains was reduced by several orders of magnitude, irrespective of multidrug-resistance or hyaluronic acid addition. The effect was less intense in Gram-negative strains (disinfection), and more pronounced in Gram-positive strains (sterilization), even at reduced THPTS concentrations or decreased light treatment intensity. Controls without THPTS or without light treatment did not indicate reduced bacterial density. PDI with THPTS and laser light was effective in all investigated bacterial strains. Gram-negative strains were less, but sufficiently, susceptible to PDI. Adding hyaluronic acid did not reduce the antibacterial treatment effect. LED-based PDI is equally effective when illumination duration is increased to compensate for reduced light intensity." @default.
• W3018032995 created "2020-05-01" @default.
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• W3018032995 date "2020-06-01" @default.
• W3018032995 modified "2023-10-18" @default.
• W3018032995 title "Tetrahydroporphyrin-tetratosylate (THPTS)-based photodynamic inactivation of critical multidrug-resistant bacteria in vitro" @default.
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• W3018032995 doi "https://doi.org/10.1016/j.ijantimicag.2020.105976" @default.
• W3018032995 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32325201" @default.
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