FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3018133722> ?p ?o ?g. }

• W3018133722 endingPage "2000013" @default.
• W3018133722 startingPage "2000013" @default.
• W3018133722 abstract "Tumor hypoxia severely impedes the therapeutic efficacy of type II photodynamic therapy (PDT) depending on singlet oxygen (1O2) generation. To combat hypoxic tumors, herein, a new approach is devised to boost superoxide radical (O2•−) photogeneration for type I PDT. Heavy atoms are introduced onto aza-BODIPY molecules (iodine substituted butoxy-aza-BODIPY, IBAB) to promote their intersystem-crossing (ISC) ability. Meanwhile, methoxy-poly(ethylene glycol)-b-poly(2-(diisopropylamino) ethyl methacrylate) (mPEG-PPDA) with enhanced electron-donating efficiency is employed as a coating matrix to encapsulate IBAB, thereby obtaining amphiphilic aza-BODIPY nanoplatforms (PPIAB NPs). Under irradiation, triplet-state IBAB in PPIAB NPs is efficiently generated from singlet state favored by the elevated ISC ability. The electron-rich environment provided by mPEG-PPDA can donate triplet-state IBAB with one electron to form charge-separated-state IBAB, which in turn transfers electron to O2 for O2•− production. Significantly, owing to recyclable O2 generated by disproportionation or Harber–Weiss/Fenton reaction, prominent O2•− is generated by PPIAB NPs even in a severe hypoxic environment (2% O2), enabling superior therapeutic efficacy (96.2% tumor-inhibition rate) over NPs not following this strategy. Thus, the proof-of-concept design of ISC-enhanced and electron-rich polymer encapsulating PPIAB NPs illuminates the path to preparing O2•− photogenerator for hypoxic cancer treatment." @default.
• W3018133722 created "2020-05-01" @default.
• W3018133722 creator A5014923027 @default.
• W3018133722 creator A5016131399 @default.
• W3018133722 creator A5019878035 @default.
• W3018133722 creator A5020186059 @default.
• W3018133722 creator A5034237051 @default.
• W3018133722 creator A5050219087 @default.
• W3018133722 creator A5060718181 @default.
• W3018133722 creator A5087996919 @default.
• W3018133722 creator A5089295119 @default.
• W3018133722 date "2020-04-19" @default.
• W3018133722 modified "2023-10-15" @default.
• W3018133722 title "Boosting O₂^•−Photogeneration via Promoting Intersystem‐Crossing and Electron‐Donating Efficiency of Aza‐BODIPY‐Based Nanoplatforms for Hypoxic‐Tumor Photodynamic Therapy" @default.
• W3018133722 cites W1878710360 @default.
• W3018133722 cites W2032012867 @default.
• W3018133722 cites W2101837290 @default.
• W3018133722 cites W2160626915 @default.
• W3018133722 cites W2256492013 @default.
• W3018133722 cites W2268788143 @default.
• W3018133722 cites W2320574135 @default.
• W3018133722 cites W2320589001 @default.
• W3018133722 cites W2524283095 @default.
• W3018133722 cites W2549509928 @default.
• W3018133722 cites W2563570451 @default.
• W3018133722 cites W2586840087 @default.
• W3018133722 cites W2589168153 @default.
• W3018133722 cites W2619224638 @default.
• W3018133722 cites W2727271995 @default.
• W3018133722 cites W2737866071 @default.
• W3018133722 cites W2745249303 @default.
• W3018133722 cites W2764028271 @default.
• W3018133722 cites W2765779358 @default.
• W3018133722 cites W2767074976 @default.
• W3018133722 cites W2767090914 @default.
• W3018133722 cites W2772326466 @default.
• W3018133722 cites W2782879922 @default.
• W3018133722 cites W2783110230 @default.
• W3018133722 cites W2808855660 @default.
• W3018133722 cites W2883621014 @default.
• W3018133722 cites W2893999721 @default.
• W3018133722 cites W2895785860 @default.
• W3018133722 cites W2896727027 @default.
• W3018133722 cites W2910747725 @default.
• W3018133722 cites W2916375270 @default.
• W3018133722 cites W2921584104 @default.
• W3018133722 cites W2943824421 @default.
• W3018133722 cites W2945876533 @default.
• W3018133722 cites W2950349405 @default.
• W3018133722 cites W2967687719 @default.
• W3018133722 cites W2986434230 @default.
• W3018133722 doi "https://doi.org/10.1002/smtd.202000013" @default.
• W3018133722 hasPublicationYear "2020" @default.
• W3018133722 type Work @default.
• W3018133722 sameAs 3018133722 @default.
• W3018133722 citedByCount "84" @default.
• W3018133722 countsByYear W30181337222020 @default.
• W3018133722 countsByYear W30181337222021 @default.
• W3018133722 countsByYear W30181337222022 @default.
• W3018133722 countsByYear W30181337222023 @default.
• W3018133722 crossrefType "journal-article" @default.
• W3018133722 hasAuthorship W3018133722A5014923027 @default.
• W3018133722 hasAuthorship W3018133722A5016131399 @default.
• W3018133722 hasAuthorship W3018133722A5019878035 @default.
• W3018133722 hasAuthorship W3018133722A5020186059 @default.
• W3018133722 hasAuthorship W3018133722A5034237051 @default.
• W3018133722 hasAuthorship W3018133722A5050219087 @default.
• W3018133722 hasAuthorship W3018133722A5060718181 @default.
• W3018133722 hasAuthorship W3018133722A5087996919 @default.
• W3018133722 hasAuthorship W3018133722A5089295119 @default.
• W3018133722 hasConcept C121332964 @default.
• W3018133722 hasConcept C178790620 @default.
• W3018133722 hasConcept C181500209 @default.
• W3018133722 hasConcept C185544564 @default.
• W3018133722 hasConcept C185592680 @default.
• W3018133722 hasConcept C192562407 @default.
• W3018133722 hasConcept C2777516457 @default.
• W3018133722 hasConcept C2781323092 @default.
• W3018133722 hasConcept C2781374752 @default.
• W3018133722 hasConcept C2781469039 @default.
• W3018133722 hasConcept C32909587 @default.
• W3018133722 hasConcept C33062035 @default.
• W3018133722 hasConcept C540031477 @default.
• W3018133722 hasConcept C62520636 @default.
• W3018133722 hasConcept C73978554 @default.
• W3018133722 hasConcept C75473681 @default.
• W3018133722 hasConcept C76766466 @default.
• W3018133722 hasConcept C91881484 @default.
• W3018133722 hasConceptScore W3018133722C121332964 @default.
• W3018133722 hasConceptScore W3018133722C178790620 @default.
• W3018133722 hasConceptScore W3018133722C181500209 @default.
• W3018133722 hasConceptScore W3018133722C185544564 @default.
• W3018133722 hasConceptScore W3018133722C185592680 @default.
• W3018133722 hasConceptScore W3018133722C192562407 @default.
• W3018133722 hasConceptScore W3018133722C2777516457 @default.
• W3018133722 hasConceptScore W3018133722C2781323092 @default.
• W3018133722 hasConceptScore W3018133722C2781374752 @default.
• W3018133722 hasConceptScore W3018133722C2781469039 @default.

• next