FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3018182199> ?p ?o ?g. }

• W3018182199 endingPage "R1067" @default.
• W3018182199 startingPage "R1058" @default.
• W3018182199 abstract "Circadian rhythms are endogenous and entrainable daily patterns of physiology and behavior. Molecular mechanisms underlie circadian rhythms, characterized by an ~24-h pattern of gene expression of core clock genes. Although it has long been known that breathing exhibits circadian rhythms, little is known concerning clock gene expression in any element of the neuromuscular system controlling breathing. Furthermore, we know little concerning gene expression necessary for specific respiratory functions, such as phrenic motor plasticity. Thus, we tested the hypotheses that transcripts for clock genes ( Bmal1, Clock, Per1, and Per2) and molecules necessary for phrenic motor plasticity ( Htr2a, Htr2b, Bdnf, and Ntrk2) oscillate in regions critical for phrenic/diaphragm motor function via RT-PCR. Tissues were collected from male Sprague-Dawley rats entrained to a 12-h light-dark cycle at 4 zeitgeber times (ZT; n = 8 rats/group): ZT5, ZT11, ZT17, and ZT23; ZT0 = lights on. Here, we demonstrate that 1) circadian clock genes ( Bmal1, Clock, Per1, and Per2) oscillate in regions critical for phrenic/diaphragm function, including the caudal medulla, ventral C3–C5 cervical spinal cord, and diaphragm; 2) the clock protein BMAL1 is localized within CtB-labeled phrenic motor neurons; 3) genes necessary for intermittent hypoxia-induced phrenic/diaphragm motor plasticity ( Htr2b and Bdnf) oscillate in the caudal medulla and ventral C3–C5 spinal cord; and 4) there is higher intensity of immunofluorescent BDNF protein within phrenic motor neurons at ZT23 compared with ZT11 ( n = 11 rats/group). These results suggest local circadian clocks exist in the phrenic motor system and confirm the potential for local circadian regulation of neuroplasticity and other elements of the neural network controlling breathing." @default.
• W3018182199 created "2020-05-01" @default.
• W3018182199 creator A5013954157 @default.
• W3018182199 creator A5038968297 @default.
• W3018182199 creator A5039796691 @default.
• W3018182199 creator A5070206960 @default.
• W3018182199 creator A5071105467 @default.
• W3018182199 creator A5076149882 @default.
• W3018182199 creator A5084518388 @default.
• W3018182199 creator A5086018301 @default.
• W3018182199 date "2020-06-01" @default.
• W3018182199 modified "2023-10-14" @default.
• W3018182199 title "Circadian clock genes and respiratory neuroplasticity genes oscillate in the phrenic motor system" @default.
• W3018182199 cites W1481869011 @default.
• W3018182199 cites W1567764795 @default.
• W3018182199 cites W1630693898 @default.
• W3018182199 cites W1731008665 @default.
• W3018182199 cites W1966825652 @default.
• W3018182199 cites W1967727674 @default.
• W3018182199 cites W1969169860 @default.
• W3018182199 cites W1972205356 @default.
• W3018182199 cites W1979125819 @default.
• W3018182199 cites W1983042938 @default.
• W3018182199 cites W1983888346 @default.
• W3018182199 cites W1986608768 @default.
• W3018182199 cites W1999742858 @default.
• W3018182199 cites W2011135037 @default.
• W3018182199 cites W2012698810 @default.
• W3018182199 cites W2014058257 @default.
• W3018182199 cites W2014313900 @default.
• W3018182199 cites W2016843706 @default.
• W3018182199 cites W2024061689 @default.
• W3018182199 cites W2034226385 @default.
• W3018182199 cites W2038123411 @default.
• W3018182199 cites W2038279594 @default.
• W3018182199 cites W2051779022 @default.
• W3018182199 cites W2053866174 @default.
• W3018182199 cites W2057080091 @default.
• W3018182199 cites W2070007868 @default.
• W3018182199 cites W2073713086 @default.
• W3018182199 cites W2077868571 @default.
• W3018182199 cites W2081878991 @default.
• W3018182199 cites W2087027867 @default.
• W3018182199 cites W2092144373 @default.
• W3018182199 cites W2093256771 @default.
• W3018182199 cites W2095493405 @default.
• W3018182199 cites W2099897858 @default.
• W3018182199 cites W2100177722 @default.
• W3018182199 cites W2107277218 @default.
• W3018182199 cites W2112643503 @default.
• W3018182199 cites W2117889752 @default.
• W3018182199 cites W2120115128 @default.
• W3018182199 cites W2121157972 @default.
• W3018182199 cites W2131664710 @default.
• W3018182199 cites W2135557712 @default.
• W3018182199 cites W2136352565 @default.
• W3018182199 cites W2139154697 @default.
• W3018182199 cites W2155034518 @default.
• W3018182199 cites W2156046417 @default.
• W3018182199 cites W2164824098 @default.
• W3018182199 cites W2166161417 @default.
• W3018182199 cites W2175705613 @default.
• W3018182199 cites W2189913914 @default.
• W3018182199 cites W2272744191 @default.
• W3018182199 cites W2275703865 @default.
• W3018182199 cites W2341489134 @default.
• W3018182199 cites W2357321999 @default.
• W3018182199 cites W2399259649 @default.
• W3018182199 cites W2472563750 @default.
• W3018182199 cites W2534086390 @default.
• W3018182199 cites W2536252358 @default.
• W3018182199 cites W254228499 @default.
• W3018182199 cites W2567503091 @default.
• W3018182199 cites W2727146109 @default.
• W3018182199 cites W2738520358 @default.
• W3018182199 cites W2810179221 @default.
• W3018182199 cites W2887174371 @default.
• W3018182199 cites W2904372366 @default.
• W3018182199 cites W2910084517 @default.
• W3018182199 cites W2914488439 @default.
• W3018182199 cites W2923168006 @default.
• W3018182199 cites W2951010171 @default.
• W3018182199 cites W2996362238 @default.
• W3018182199 cites W4232526644 @default.
• W3018182199 cites W56215486 @default.
• W3018182199 doi "https://doi.org/10.1152/ajpregu.00010.2020" @default.
• W3018182199 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7311680" @default.
• W3018182199 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32348679" @default.
• W3018182199 hasPublicationYear "2020" @default.
• W3018182199 type Work @default.
• W3018182199 sameAs 3018182199 @default.
• W3018182199 citedByCount "13" @default.
• W3018182199 countsByYear W30181821992021 @default.
• W3018182199 countsByYear W30181821992022 @default.
• W3018182199 countsByYear W30181821992023 @default.
• W3018182199 crossrefType "journal-article" @default.
• W3018182199 hasAuthorship W3018182199A5013954157 @default.
• W3018182199 hasAuthorship W3018182199A5038968297 @default.

• next