FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3018220382> ?p ?o ?g. }

• W3018220382 abstract "Heart failure (HF) post-acute myocardial infarction (AMI) leads to a large number of hospitalizations and deaths worldwide. Danqi pill (DQP) is included in the 2015 national pharmacopoeia and widely applied in the treatment of HF in clinics in China. We examined whether DQP acted on glucose metabolism to protect against HF post-AMI via hypoxia inducible factor-1 alpha (HIF-1α)/peroxisome proliferator-activated receptor α co-activator (PGC-1α) pathway.In this study, left anterior descending (LAD) artery ligation induced HF post-AMI rats and oxygen-glucose deprivation-reperfusion (OGD/R)-induced H9C2 cell model were structured to explore the efficacy and mechanism of DQP. Here we showed that DQP protected the heart against ischemic damage as evidenced by improved cardiac functions and attenuated inflammatory infiltration. The expressions of critical proteins involved in glucose intake and transportation such as GLUT4 and PKM2 were up-regulated, while negative regulatory proteins involved in oxidative phosphorylation were attenuated in the treatment of DQP. Moreover, DQP up-regulated NRF1 and TFAM, promoted mitochondrial biogenesis and increased myocardial adenosine triphosphate (ATP) level. The protection effects of DQP were significantly compromised by HIF-1α siRNA, suggesting that HIF-1α signaling pathway was the potential target of DQP on HF post-AMI.DQP exhibits the efficacy to improve myocardial glucose metabolism, mitochondrial oxidative phosphorylation and biogenesis by regulating HIF-1α/PGC-1α signaling pathway in HF post-AMI rats." @default.
• W3018220382 created "2020-05-01" @default.
• W3018220382 creator A5034711601 @default.
• W3018220382 creator A5040621231 @default.
• W3018220382 creator A5046597133 @default.
• W3018220382 creator A5046627141 @default.
• W3018220382 creator A5056378571 @default.
• W3018220382 creator A5066102428 @default.
• W3018220382 creator A5077544471 @default.
• W3018220382 creator A5088068305 @default.
• W3018220382 creator A5089812226 @default.
• W3018220382 date "2020-04-21" @default.
• W3018220382 modified "2023-10-17" @default.
• W3018220382 title "Danqi Pill Protects Against Heart Failure Post-Acute Myocardial Infarction via HIF-1α/PGC-1α Mediated Glucose Metabolism Pathway" @default.
• W3018220382 cites W1483811243 @default.
• W3018220382 cites W1584301804 @default.
• W3018220382 cites W1966954307 @default.
• W3018220382 cites W2001666774 @default.
• W3018220382 cites W2015326030 @default.
• W3018220382 cites W2020161055 @default.
• W3018220382 cites W2034872735 @default.
• W3018220382 cites W2035938633 @default.
• W3018220382 cites W2049111653 @default.
• W3018220382 cites W2052678651 @default.
• W3018220382 cites W2070536001 @default.
• W3018220382 cites W2071518542 @default.
• W3018220382 cites W2072727898 @default.
• W3018220382 cites W2080659100 @default.
• W3018220382 cites W2102308209 @default.
• W3018220382 cites W2104740972 @default.
• W3018220382 cites W2112125919 @default.
• W3018220382 cites W2144602958 @default.
• W3018220382 cites W2152704150 @default.
• W3018220382 cites W2155099139 @default.
• W3018220382 cites W2155446034 @default.
• W3018220382 cites W2280120762 @default.
• W3018220382 cites W2281079411 @default.
• W3018220382 cites W2326439055 @default.
• W3018220382 cites W2335697479 @default.
• W3018220382 cites W2427094903 @default.
• W3018220382 cites W2530161208 @default.
• W3018220382 cites W2564174751 @default.
• W3018220382 cites W2565443325 @default.
• W3018220382 cites W2594370808 @default.
• W3018220382 cites W2598885031 @default.
• W3018220382 cites W2619927515 @default.
• W3018220382 cites W2769614877 @default.
• W3018220382 cites W2770344912 @default.
• W3018220382 cites W2779296043 @default.
• W3018220382 cites W2792680644 @default.
• W3018220382 cites W2793471471 @default.
• W3018220382 cites W2796876599 @default.
• W3018220382 cites W2798144279 @default.
• W3018220382 cites W2803600657 @default.
• W3018220382 cites W2888605276 @default.
• W3018220382 cites W2894500353 @default.
• W3018220382 cites W2898311121 @default.
• W3018220382 cites W2902953556 @default.
• W3018220382 cites W2906890594 @default.
• W3018220382 cites W2955340545 @default.
• W3018220382 cites W4229508205 @default.
• W3018220382 doi "https://doi.org/10.3389/fphar.2020.00458" @default.
• W3018220382 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7187888" @default.
• W3018220382 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32372956" @default.
• W3018220382 hasPublicationYear "2020" @default.
• W3018220382 type Work @default.
• W3018220382 sameAs 3018220382 @default.
• W3018220382 citedByCount "11" @default.
• W3018220382 countsByYear W30182203822021 @default.
• W3018220382 countsByYear W30182203822022 @default.
• W3018220382 countsByYear W30182203822023 @default.
• W3018220382 crossrefType "journal-article" @default.
• W3018220382 hasAuthorship W3018220382A5034711601 @default.
• W3018220382 hasAuthorship W3018220382A5040621231 @default.
• W3018220382 hasAuthorship W3018220382A5046597133 @default.
• W3018220382 hasAuthorship W3018220382A5046627141 @default.
• W3018220382 hasAuthorship W3018220382A5056378571 @default.
• W3018220382 hasAuthorship W3018220382A5066102428 @default.
• W3018220382 hasAuthorship W3018220382A5077544471 @default.
• W3018220382 hasAuthorship W3018220382A5088068305 @default.
• W3018220382 hasAuthorship W3018220382A5089812226 @default.
• W3018220382 hasBestOaLocation W30182203821 @default.
• W3018220382 hasConcept C11960822 @default.
• W3018220382 hasConcept C126322002 @default.
• W3018220382 hasConcept C164705383 @default.
• W3018220382 hasConcept C185592680 @default.
• W3018220382 hasConcept C2778198053 @default.
• W3018220382 hasConcept C2780124434 @default.
• W3018220382 hasConcept C500558357 @default.
• W3018220382 hasConcept C55493867 @default.
• W3018220382 hasConcept C57600042 @default.
• W3018220382 hasConcept C71924100 @default.
• W3018220382 hasConcept C97029542 @default.
• W3018220382 hasConcept C98274493 @default.
• W3018220382 hasConceptScore W3018220382C11960822 @default.
• W3018220382 hasConceptScore W3018220382C126322002 @default.
• W3018220382 hasConceptScore W3018220382C164705383 @default.
• W3018220382 hasConceptScore W3018220382C185592680 @default.
• W3018220382 hasConceptScore W3018220382C2778198053 @default.
• W3018220382 hasConceptScore W3018220382C2780124434 @default.

• next