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- W3018277836 abstract "Microgravity induces a number of significant physiological changes in the cardiovascular, nervous, immune systems, as well as the bone tissue of astronauts. Changes in cell adhesion properties are one aspect affected during long-term spaceflights in mammalian cells. Cellular adhesion behaviors can be divided into cell–cell and cell–matrix adhesion. These behaviors trigger cell–cell recognition, conjugation, migration, cytoskeletal rearrangement, and signal transduction. Cellular adhesion molecule (CAM) is a general term for macromolecules that mediate the contact and binding between cells or between cells and the extracellular matrix (ECM). In this review, we summarize the four major classes of adhesion molecules that regulate cell adhesion, including integrins, immunoglobulin superfamily (Ig-SF), cadherins, and selectin. Moreover, we discuss the effects of spaceflight and simulated microgravity on the adhesion of endothelial cells, immune cells, tumor cells, stem cells, osteoblasts, muscle cells, and other types of cells. Further studies on the effects of microgravity on cell adhesion and the corresponding physiological behaviors may help increase the safety and improve the health of astronauts in space." @default.
- W3018277836 created "2020-05-01" @default.
- W3018277836 creator A5002149105 @default.
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- W3018277836 creator A5020968950 @default.
- W3018277836 creator A5027693027 @default.
- W3018277836 creator A5040765501 @default.
- W3018277836 creator A5062670319 @default.
- W3018277836 date "2020-04-25" @default.
- W3018277836 modified "2023-10-03" @default.
- W3018277836 title "The Impact of Spaceflight and Simulated Microgravity on Cell Adhesion" @default.
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