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- W3018284986 endingPage "5079" @default.
- W3018284986 startingPage "5068" @default.
- W3018284986 abstract "Central to proteopathies and leading to most age‐related neurodegenerative disorders is a failure in protein quality control (PQC). To harness the toxicity of misfolded and damaged disease proteins, such proteins are either refolded, degraded by temporal PQC, or sequestered by spatial PQC into specific, organelle‐associated, compartments within the cell. Here, we discuss the impact of vesicle trafficking pathways in general, and syntaxin 5 in particular, as key players in spatial PQC directing misfolded proteins to the surface of vacuole and mitochondria, which facilitates their clearance and detoxification. Since boosting vesicle trafficking genetically can positively impact on spatial PQC and make cells less sensitive to misfolded disease proteins, we speculate that regulators of such trafficking might serve as therapeutic targets for age‐related neurological disorders." @default.
- W3018284986 created "2020-05-01" @default.
- W3018284986 creator A5006266911 @default.
- W3018284986 creator A5041540706 @default.
- W3018284986 creator A5056671566 @default.
- W3018284986 date "2020-05-10" @default.
- W3018284986 modified "2023-09-30" @default.
- W3018284986 title "Hitchhiking on vesicles: a way to harness age‐related proteopathies?" @default.
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