Matches in SemOpenAlex for { <https://semopenalex.org/work/W3018303399> ?p ?o ?g. }
- W3018303399 endingPage "19.2020" @default.
- W3018303399 startingPage "ENEURO.0500" @default.
- W3018303399 abstract "Cortical neuronal circuits along the sensorimotor pathways are shaped by experience during critical periods of heightened plasticity in early postnatal development. After closure of critical periods, measured histologically by the formation and maintenance of extracellular matrix structures called perineuronal nets (PNNs), the adult mouse brain exhibits restricted plasticity and maturity. Mature PNNs are typically considered to be stable structures that restrict synaptic plasticity on cortical parvalbumin+ (PV+) GABAergic neurons. Changes in environment (i.e., novel behavioral training) or social contexts (i.e., motherhood) are known to elicit synaptic plasticity in relevant neural circuitry. However, little is known about concomitant changes in the PNNs surrounding the cortical PV+ GABAergic neurons. Here, we show novel changes in PNN density in the primary somatosensory cortex (SS1) of adult female mice after maternal experience [called surrogate (Sur)], using systematic microscopy analysis of a whole brain region. On average, PNNs were increased in the right barrel field and decreased in the left forelimb regions. Individual mice had left hemisphere dominance in PNN density. Using adult female mice deficient in methyl-CpG-binding protein 2 (MECP2), an epigenetic regulator involved in regulating experience-dependent plasticity, we found that MECP2 is critical for this precise and dynamic expression of PNN. Adult naive Mecp2-heterozygous (Het) females had increased PNN density in specific subregions in both hemispheres before maternal experience, compared with wild-type (WT) littermate controls. The laterality in PNN expression seen in naive Het (NH) was lost after maternal experience in Sur Het (SH) mice, suggesting possible intact mechanisms for plasticity. Together, our results identify subregion and hemisphere-specific alterations in PNN expression in adult females, suggesting extracellular matrix plasticity as a possible neurobiological mechanism for adult behaviors in rodents." @default.
- W3018303399 created "2020-05-01" @default.
- W3018303399 creator A5002511372 @default.
- W3018303399 creator A5017727012 @default.
- W3018303399 creator A5035551133 @default.
- W3018303399 creator A5038631781 @default.
- W3018303399 creator A5040614367 @default.
- W3018303399 creator A5050630309 @default.
- W3018303399 creator A5050699822 @default.
- W3018303399 creator A5052246695 @default.
- W3018303399 creator A5066424668 @default.
- W3018303399 creator A5071459482 @default.
- W3018303399 creator A5082393598 @default.
- W3018303399 creator A5088932134 @default.
- W3018303399 creator A5091124725 @default.
- W3018303399 date "2020-04-24" @default.
- W3018303399 modified "2023-09-24" @default.
- W3018303399 title "Lateralized Expression of Cortical Perineuronal Nets during Maternal Experience is Dependent on MECP2" @default.
- W3018303399 cites W1156101481 @default.
- W3018303399 cites W1501527294 @default.
- W3018303399 cites W1558633943 @default.
- W3018303399 cites W1559185481 @default.
- W3018303399 cites W1559742681 @default.
- W3018303399 cites W1562783671 @default.
- W3018303399 cites W1599240209 @default.
- W3018303399 cites W1966167828 @default.
- W3018303399 cites W1986126224 @default.
- W3018303399 cites W1986214383 @default.
- W3018303399 cites W1988371720 @default.
- W3018303399 cites W1988690693 @default.
- W3018303399 cites W1988993555 @default.
- W3018303399 cites W1989780964 @default.
- W3018303399 cites W1990520898 @default.
- W3018303399 cites W1993916224 @default.
- W3018303399 cites W1999828796 @default.
- W3018303399 cites W2001936578 @default.
- W3018303399 cites W2006225961 @default.
- W3018303399 cites W2006628284 @default.
- W3018303399 cites W2007162991 @default.
- W3018303399 cites W2011786851 @default.
- W3018303399 cites W2014364856 @default.
- W3018303399 cites W2014960948 @default.
- W3018303399 cites W2015734897 @default.
- W3018303399 cites W2019492932 @default.
- W3018303399 cites W2020405318 @default.
- W3018303399 cites W2025806474 @default.
- W3018303399 cites W2025990173 @default.
- W3018303399 cites W2026751327 @default.
- W3018303399 cites W2030127666 @default.
- W3018303399 cites W2030631663 @default.
- W3018303399 cites W2032089725 @default.
- W3018303399 cites W2033388169 @default.
- W3018303399 cites W2033614083 @default.
- W3018303399 cites W2035016973 @default.
- W3018303399 cites W2035410949 @default.
- W3018303399 cites W2039276157 @default.
- W3018303399 cites W2039539900 @default.
- W3018303399 cites W2040502575 @default.
- W3018303399 cites W2042726318 @default.
- W3018303399 cites W2044185100 @default.
- W3018303399 cites W2044233502 @default.
- W3018303399 cites W2046022138 @default.
- W3018303399 cites W2057493537 @default.
- W3018303399 cites W2059480421 @default.
- W3018303399 cites W2065527300 @default.
- W3018303399 cites W2065637628 @default.
- W3018303399 cites W2067214903 @default.
- W3018303399 cites W2067367200 @default.
- W3018303399 cites W2068111240 @default.
- W3018303399 cites W2068523411 @default.
- W3018303399 cites W2069718976 @default.
- W3018303399 cites W2070661973 @default.
- W3018303399 cites W2072661586 @default.
- W3018303399 cites W2076578269 @default.
- W3018303399 cites W2078474557 @default.
- W3018303399 cites W2081756408 @default.
- W3018303399 cites W2085900799 @default.
- W3018303399 cites W2091187766 @default.
- W3018303399 cites W2092620953 @default.
- W3018303399 cites W2097087118 @default.
- W3018303399 cites W2099540110 @default.
- W3018303399 cites W2106489369 @default.
- W3018303399 cites W2108470366 @default.
- W3018303399 cites W2112406695 @default.
- W3018303399 cites W2113548375 @default.
- W3018303399 cites W2127311839 @default.
- W3018303399 cites W2129032286 @default.
- W3018303399 cites W2138401085 @default.
- W3018303399 cites W2138412572 @default.
- W3018303399 cites W2149119305 @default.
- W3018303399 cites W2152504800 @default.
- W3018303399 cites W2155543956 @default.
- W3018303399 cites W2239279248 @default.
- W3018303399 cites W2239707532 @default.
- W3018303399 cites W2268380328 @default.
- W3018303399 cites W2320983896 @default.
- W3018303399 cites W2410908538 @default.
- W3018303399 cites W2553239728 @default.