FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3018367384> ?p ?o ?g. }

• W3018367384 abstract "Abstract Biofilms have significant role in microbial persistence, antibiotic resistance and chronic infections; consequently, there is a pressing need for development of novel “anti-biofilm strategies”. One of the fundamental mechanisms involved in biofilm formation is protein-protein interactions of ‘amyloid like proteins’ (ALPs) in extracellular matrix. Such interactions could be potential targets for development of novel anti-biofilm strategies; therefore, assessing the structural features of these interactions could be of great scientific value. Characterization of biomolecular interaction with conventional structure biology tools including X-Ray diffraction and Nuclear Magnetic Resonance is technically challenging, expensive and time-consuming. In contrast, modelling such interactions is time-efficient, economical and might provide deeper understanding of structural basis of interactions. Therefore, during the present study, protein-protein interaction of TasA (28-261) –TapA (33-253) (which is a decisive process for biofilm formation by Bacillus subtilis ) was modeled using in silico approaches viz., molecular modelling, protein-protein docking and molecular dynamics simulations. Results identified amino-acid residues present within intrinsically disordered regions of both proteins to be critical for interaction. These results were further supported with PCA and FEL analyses. Results presented here represent novel finding and we hypothesize that aa identified during the present study could be targeted for inhibition of biofilm formation by B. subtilis ." @default.
• W3018367384 created "2020-05-01" @default.
• W3018367384 creator A5013671037 @default.
• W3018367384 creator A5016334179 @default.
• W3018367384 creator A5034175379 @default.
• W3018367384 creator A5034944928 @default.
• W3018367384 creator A5067101223 @default.
• W3018367384 creator A5082120780 @default.
• W3018367384 date "2020-04-27" @default.
• W3018367384 modified "2023-09-25" @default.
• W3018367384 title "Computational investigation for modelling the protein-protein interaction of TasA(28-261) – TapA(33-253): a decisive process in biofilm formation by Bacillus subtilis" @default.
• W3018367384 cites W1575401889 @default.
• W3018367384 cites W1607931568 @default.
• W3018367384 cites W1881113194 @default.
• W3018367384 cites W1967239401 @default.
• W3018367384 cites W1981369081 @default.
• W3018367384 cites W1986191025 @default.
• W3018367384 cites W1995441620 @default.
• W3018367384 cites W1996251178 @default.
• W3018367384 cites W2005237666 @default.
• W3018367384 cites W2021785060 @default.
• W3018367384 cites W2029667189 @default.
• W3018367384 cites W2053820259 @default.
• W3018367384 cites W2067014806 @default.
• W3018367384 cites W2070300719 @default.
• W3018367384 cites W2079953901 @default.
• W3018367384 cites W2086603752 @default.
• W3018367384 cites W2104700141 @default.
• W3018367384 cites W2120978086 @default.
• W3018367384 cites W2124380622 @default.
• W3018367384 cites W2127322768 @default.
• W3018367384 cites W2129115026 @default.
• W3018367384 cites W2129562311 @default.
• W3018367384 cites W2130606742 @default.
• W3018367384 cites W2131900949 @default.
• W3018367384 cites W2132589721 @default.
• W3018367384 cites W2143027164 @default.
• W3018367384 cites W2152042119 @default.
• W3018367384 cites W2152191747 @default.
• W3018367384 cites W2155796229 @default.
• W3018367384 cites W2160451368 @default.
• W3018367384 cites W2160544821 @default.
• W3018367384 cites W2162683592 @default.
• W3018367384 cites W2170564629 @default.
• W3018367384 cites W2399812463 @default.
• W3018367384 cites W2537623931 @default.
• W3018367384 cites W2572080171 @default.
• W3018367384 cites W2761783016 @default.
• W3018367384 cites W2789731003 @default.
• W3018367384 cites W2899355381 @default.
• W3018367384 cites W4213354399 @default.
• W3018367384 cites W4230690150 @default.
• W3018367384 cites W4230784961 @default.
• W3018367384 doi "https://doi.org/10.1101/2020.04.26.062109" @default.
• W3018367384 hasPublicationYear "2020" @default.
• W3018367384 type Work @default.
• W3018367384 sameAs 3018367384 @default.
• W3018367384 citedByCount "0" @default.
• W3018367384 crossrefType "posted-content" @default.
• W3018367384 hasAuthorship W3018367384A5013671037 @default.
• W3018367384 hasAuthorship W3018367384A5016334179 @default.
• W3018367384 hasAuthorship W3018367384A5034175379 @default.
• W3018367384 hasAuthorship W3018367384A5034944928 @default.
• W3018367384 hasAuthorship W3018367384A5067101223 @default.
• W3018367384 hasAuthorship W3018367384A5082120780 @default.
• W3018367384 hasBestOaLocation W30183673841 @default.
• W3018367384 hasConcept C104317684 @default.
• W3018367384 hasConcept C11804247 @default.
• W3018367384 hasConcept C12554922 @default.
• W3018367384 hasConcept C185592680 @default.
• W3018367384 hasConcept C2775905019 @default.
• W3018367384 hasConcept C2777272437 @default.
• W3018367384 hasConcept C47701112 @default.
• W3018367384 hasConcept C523546767 @default.
• W3018367384 hasConcept C54355233 @default.
• W3018367384 hasConcept C55493867 @default.
• W3018367384 hasConcept C58123911 @default.
• W3018367384 hasConcept C70721500 @default.
• W3018367384 hasConcept C86803240 @default.
• W3018367384 hasConceptScore W3018367384C104317684 @default.
• W3018367384 hasConceptScore W3018367384C11804247 @default.
• W3018367384 hasConceptScore W3018367384C12554922 @default.
• W3018367384 hasConceptScore W3018367384C185592680 @default.
• W3018367384 hasConceptScore W3018367384C2775905019 @default.
• W3018367384 hasConceptScore W3018367384C2777272437 @default.
• W3018367384 hasConceptScore W3018367384C47701112 @default.
• W3018367384 hasConceptScore W3018367384C523546767 @default.
• W3018367384 hasConceptScore W3018367384C54355233 @default.
• W3018367384 hasConceptScore W3018367384C55493867 @default.
• W3018367384 hasConceptScore W3018367384C58123911 @default.
• W3018367384 hasConceptScore W3018367384C70721500 @default.
• W3018367384 hasConceptScore W3018367384C86803240 @default.
• W3018367384 hasLocation W30183673841 @default.
• W3018367384 hasOpenAccess W3018367384 @default.
• W3018367384 hasPrimaryLocation W30183673841 @default.
• W3018367384 hasRelatedWork W13899322 @default.
• W3018367384 hasRelatedWork W16968007 @default.
• W3018367384 hasRelatedWork W17368162 @default.
• W3018367384 hasRelatedWork W17468178 @default.
• W3018367384 hasRelatedWork W17594683 @default.

• next