FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3018428298> ?p ?o ?g. }

• W3018428298 abstract "Abstract Obstructive sleep apnea (OSA) is a common sleep disorder associated with obesity. Emerging evidence suggest that OSA increases the risk of cardiovascular morbidity and mortality partly via accelerating the process of cellular aging. Thus, we sought to examine the effects of intermittent hypoxia (IH), a hallmark of OSA, on senescence in human white preadipocytes. We demonstrate that chronic IH is associated with an increased generation of mitochondrial reactive oxygen species along with increased prevalence of cells with nuclear localization of γH2AX & p16. A higher prevalence of cells positive for senescence-associated β-galactosidase activity was also evident with chronic IH exposure. Intervention with aspirin, atorvastatin or renin-angiotensin system (RAS) inhibitors effectively attenuated IH-mediated senescence-like phenotype. Importantly, the validity of in vitro findings was confirmed by examination of the subcutaneous abdominal adipose tissue which showed that OSA patients had a significantly higher percentage of cells with nuclear localization of γH2AX & p16 than non-OSA individuals (20.1 ± 10.8% vs. 10.3 ± 2.7%, P adjusted < 0.001). Furthermore, the frequency of dual positive γH2AX & p16 nuclei in adipose tissue of OSA patients receiving statin, aspirin, and/or RAS inhibitors was comparable to non-OSA individuals. This study identifies chronic IH as a trigger of senescence-like phenotype in preadipocytes. Together, our data suggest that OSA may be considered as a senescence-related disorder." @default.
• W3018428298 created "2020-05-01" @default.
• W3018428298 creator A5003195595 @default.
• W3018428298 creator A5023558309 @default.
• W3018428298 creator A5023934036 @default.
• W3018428298 creator A5026563863 @default.
• W3018428298 creator A5072679208 @default.
• W3018428298 creator A5077261111 @default.
• W3018428298 creator A5084645609 @default.
• W3018428298 creator A5090382017 @default.
• W3018428298 date "2020-04-22" @default.
• W3018428298 modified "2023-10-16" @default.
• W3018428298 title "Chronic Intermittent Hypoxia Triggers a Senescence-like Phenotype in Human White Preadipocytes" @default.
• W3018428298 cites W1279301897 @default.
• W3018428298 cites W1535485604 @default.
• W3018428298 cites W1591584417 @default.
• W3018428298 cites W1608849851 @default.
• W3018428298 cites W180946569 @default.
• W3018428298 cites W1965516597 @default.
• W3018428298 cites W1973133147 @default.
• W3018428298 cites W1974284080 @default.
• W3018428298 cites W1974548284 @default.
• W3018428298 cites W1976416423 @default.
• W3018428298 cites W1982481909 @default.
• W3018428298 cites W1984520586 @default.
• W3018428298 cites W1984668226 @default.
• W3018428298 cites W1986751808 @default.
• W3018428298 cites W1998914290 @default.
• W3018428298 cites W2004206534 @default.
• W3018428298 cites W2010254570 @default.
• W3018428298 cites W2019276374 @default.
• W3018428298 cites W2020717634 @default.
• W3018428298 cites W2038043270 @default.
• W3018428298 cites W2040456946 @default.
• W3018428298 cites W2046859561 @default.
• W3018428298 cites W2047877950 @default.
• W3018428298 cites W2049680139 @default.
• W3018428298 cites W2060097209 @default.
• W3018428298 cites W2067400934 @default.
• W3018428298 cites W2069119991 @default.
• W3018428298 cites W2072648757 @default.
• W3018428298 cites W2072741172 @default.
• W3018428298 cites W2077450385 @default.
• W3018428298 cites W2078184649 @default.
• W3018428298 cites W2099540110 @default.
• W3018428298 cites W2102979143 @default.
• W3018428298 cites W2108887402 @default.
• W3018428298 cites W2110230208 @default.
• W3018428298 cites W2121141378 @default.
• W3018428298 cites W2131250713 @default.
• W3018428298 cites W2133481218 @default.
• W3018428298 cites W2151079160 @default.
• W3018428298 cites W2153316977 @default.
• W3018428298 cites W2160629168 @default.
• W3018428298 cites W2160848960 @default.
• W3018428298 cites W2165301441 @default.
• W3018428298 cites W2167644260 @default.
• W3018428298 cites W2168032910 @default.
• W3018428298 cites W2191745121 @default.
• W3018428298 cites W2266290735 @default.
• W3018428298 cites W2279209513 @default.
• W3018428298 cites W2309787605 @default.
• W3018428298 cites W2504155943 @default.
• W3018428298 cites W2504372097 @default.
• W3018428298 cites W2508221593 @default.
• W3018428298 cites W2605674430 @default.
• W3018428298 cites W2737063622 @default.
• W3018428298 cites W2772876937 @default.
• W3018428298 cites W2890201783 @default.
• W3018428298 cites W2906721882 @default.
• W3018428298 cites W2946076739 @default.
• W3018428298 cites W3023775830 @default.
• W3018428298 doi "https://doi.org/10.1038/s41598-020-63761-7" @default.
• W3018428298 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7176724" @default.
• W3018428298 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32321999" @default.
• W3018428298 hasPublicationYear "2020" @default.
• W3018428298 type Work @default.
• W3018428298 sameAs 3018428298 @default.
• W3018428298 citedByCount "18" @default.
• W3018428298 countsByYear W30184282982021 @default.
• W3018428298 countsByYear W30184282982022 @default.
• W3018428298 countsByYear W30184282982023 @default.
• W3018428298 crossrefType "journal-article" @default.
• W3018428298 hasAuthorship W3018428298A5003195595 @default.
• W3018428298 hasAuthorship W3018428298A5023558309 @default.
• W3018428298 hasAuthorship W3018428298A5023934036 @default.
• W3018428298 hasAuthorship W3018428298A5026563863 @default.
• W3018428298 hasAuthorship W3018428298A5072679208 @default.
• W3018428298 hasAuthorship W3018428298A5077261111 @default.
• W3018428298 hasAuthorship W3018428298A5084645609 @default.
• W3018428298 hasAuthorship W3018428298A5090382017 @default.
• W3018428298 hasBestOaLocation W30184282981 @default.
• W3018428298 hasConcept C104317684 @default.
• W3018428298 hasConcept C126322002 @default.
• W3018428298 hasConcept C127716648 @default.
• W3018428298 hasConcept C134018914 @default.
• W3018428298 hasConcept C151955695 @default.
• W3018428298 hasConcept C171089720 @default.
• W3018428298 hasConcept C178790620 @default.
• W3018428298 hasConcept C185592680 @default.

• next