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• W3018439210 abstract "We performed a retrospective study to evaluate clinical effectiveness of vancomycin loading strategy and factors associated with achieving optimal Cmin. Patients administered vancomycin for ≥72 h from January to June 2018 were enrolled. Patients were divided into two groups: loading (LD) and non-loading (NLD). LD was defined as initial vancomycin dose ≥20 mg/kg and ≥120% of maintenance dose. During study period, 70 and 71 received initial LD (24.2 ± 2.5 mg/kg) and NLD (17.3 ± 3.3 mg/kg) doses of vancomycin, respectively (p < .001). Achievement of optimal Cmin was not different before administration of the third dose (24.4% in LD versus 18.2% in NLD, p = .484) and within 72 h (22.9% versus 28.2%, p = .759). Risk factors for failure to achieve optimal Cmin before administration of the third dose were higher creatinine clearance and higher level of serum albumin. Therefore, more sufficient loading or patient-specific dose strategies should be used to achieve optimal serum vancomycin Cmin." @default.
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• W3018439210 date "2020-04-23" @default.
• W3018439210 modified "2023-09-23" @default.
• W3018439210 title "Weight-based vancomycin loading strategy may not improve achievement of optimal vancomycin concentration in patients with preserved renal function" @default.
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• W3018439210 doi "https://doi.org/10.1080/1120009x.2020.1755590" @default.
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