FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3018489634> ?p ?o ?g. }

• W3018489634 endingPage "65" @default.
• W3018489634 startingPage "59" @default.
• W3018489634 abstract "Human lungs single-cell RNA sequencing data from healthy donors (elderly and young; GEO accession no. GSE122960) were analyzed to isolate and specifically study gene expression in alveolar type II cells. Colocalization of angiotensin-converting enzyme 2 (ACE2) and TMPRSS2 enables severe acute respiratory syndrome coronavirus 2 (SARS-CoV 2) to enter the cells. Expression levels of these genes in the alveolar type II cells of elderly and young patients were comparable and, therefore, do not seem to be responsible for worse outcomes observed in coronavirus disease 2019 (COVID-19) affected elderly. In cells from the elderly, 263 genes were downregulated and 95 upregulated. Superoxide dismutase 3 (SOD3) was identified as the top-ranked gene that was most downregulated in the elderly. Other redox-active genes that were also downregulated in cells from the elderly included activating transcription factor 4 (ATF4) and metallothionein 2A (M2TA). ATF4 is an endoplasmic reticulum stress sensor that defends lungs via induction of heme oxygenase 1. The study of downstream factors known to be induced by ATF4, according to Ingenuity Pathway Analysis™, identified 24 candidates. Twenty-one of these were significantly downregulated in the cells from the elderly. These downregulated candidates were subjected to enrichment using the Reactome Database identifying that in the elderly, the ability to respond to heme deficiency and the ATF4-dependent ability to respond to endoplasmic reticulum stress is significantly compromised. SOD3-based therapeutic strategies have provided beneficial results in treating lung disorders including fibrosis. The findings of this study propose the hypotheses that lung-specific delivery of SOD3/ATF4-related antioxidants will work in synergy with promising antiviral drugs such as remdesivir to further improve COVID-19 outcomes in the elderly." @default.
• W3018489634 created "2020-05-01" @default.
• W3018489634 creator A5050636457 @default.
• W3018489634 creator A5056267400 @default.
• W3018489634 creator A5076274278 @default.
• W3018489634 creator A5083420969 @default.
• W3018489634 date "2020-07-10" @default.
• W3018489634 modified "2023-10-06" @default.
• W3018489634 title "Is Low Alveolar Type II Cell<i>SOD3</i>in the Lungs of Elderly Linked to the Observed Severity of COVID-19?" @default.
• W3018489634 cites W1586165122 @default.
• W3018489634 cites W1965092945 @default.
• W3018489634 cites W2017292179 @default.
• W3018489634 cites W2041607432 @default.
• W3018489634 cites W2069089843 @default.
• W3018489634 cites W2111079603 @default.
• W3018489634 cites W2133676879 @default.
• W3018489634 cites W2137569729 @default.
• W3018489634 cites W2157125647 @default.
• W3018489634 cites W2172199562 @default.
• W3018489634 cites W2462113069 @default.
• W3018489634 cites W2753969837 @default.
• W3018489634 cites W2766630179 @default.
• W3018489634 cites W2782133916 @default.
• W3018489634 cites W2883745760 @default.
• W3018489634 cites W2904478560 @default.
• W3018489634 cites W2907514116 @default.
• W3018489634 cites W2914134723 @default.
• W3018489634 cites W2969997631 @default.
• W3018489634 cites W2972054198 @default.
• W3018489634 cites W3001118548 @default.
• W3018489634 cites W3009912996 @default.
• W3018489634 cites W3009994579 @default.
• W3018489634 cites W3012253443 @default.
• W3018489634 cites W3012421327 @default.
• W3018489634 cites W329654239 @default.
• W3018489634 cites W4241350782 @default.
• W3018489634 doi "https://doi.org/10.1089/ars.2020.8111" @default.
• W3018489634 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7307702" @default.
• W3018489634 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32323565" @default.
• W3018489634 hasPublicationYear "2020" @default.
• W3018489634 type Work @default.
• W3018489634 sameAs 3018489634 @default.
• W3018489634 citedByCount "76" @default.
• W3018489634 countsByYear W30184896342020 @default.
• W3018489634 countsByYear W30184896342021 @default.
• W3018489634 countsByYear W30184896342022 @default.
• W3018489634 countsByYear W30184896342023 @default.
• W3018489634 crossrefType "journal-article" @default.
• W3018489634 hasAuthorship W3018489634A5050636457 @default.
• W3018489634 hasAuthorship W3018489634A5056267400 @default.
• W3018489634 hasAuthorship W3018489634A5076274278 @default.
• W3018489634 hasAuthorship W3018489634A5083420969 @default.
• W3018489634 hasBestOaLocation W30184896342 @default.
• W3018489634 hasConcept C104317684 @default.
• W3018489634 hasConcept C126322002 @default.
• W3018489634 hasConcept C127561419 @default.
• W3018489634 hasConcept C139447449 @default.
• W3018489634 hasConcept C158617107 @default.
• W3018489634 hasConcept C203014093 @default.
• W3018489634 hasConcept C2776348555 @default.
• W3018489634 hasConcept C2777714996 @default.
• W3018489634 hasConcept C2780900454 @default.
• W3018489634 hasConcept C2781244666 @default.
• W3018489634 hasConcept C502942594 @default.
• W3018489634 hasConcept C54355233 @default.
• W3018489634 hasConcept C71924100 @default.
• W3018489634 hasConcept C86803240 @default.
• W3018489634 hasConcept C95444343 @default.
• W3018489634 hasConceptScore W3018489634C104317684 @default.
• W3018489634 hasConceptScore W3018489634C126322002 @default.
• W3018489634 hasConceptScore W3018489634C127561419 @default.
• W3018489634 hasConceptScore W3018489634C139447449 @default.
• W3018489634 hasConceptScore W3018489634C158617107 @default.
• W3018489634 hasConceptScore W3018489634C203014093 @default.
• W3018489634 hasConceptScore W3018489634C2776348555 @default.
• W3018489634 hasConceptScore W3018489634C2777714996 @default.
• W3018489634 hasConceptScore W3018489634C2780900454 @default.
• W3018489634 hasConceptScore W3018489634C2781244666 @default.
• W3018489634 hasConceptScore W3018489634C502942594 @default.
• W3018489634 hasConceptScore W3018489634C54355233 @default.
• W3018489634 hasConceptScore W3018489634C71924100 @default.
• W3018489634 hasConceptScore W3018489634C86803240 @default.
• W3018489634 hasConceptScore W3018489634C95444343 @default.
• W3018489634 hasIssue "2" @default.
• W3018489634 hasLocation W30184896341 @default.
• W3018489634 hasLocation W30184896342 @default.
• W3018489634 hasLocation W30184896343 @default.
• W3018489634 hasLocation W30184896344 @default.
• W3018489634 hasOpenAccess W3018489634 @default.
• W3018489634 hasPrimaryLocation W30184896341 @default.
• W3018489634 hasRelatedWork W1492346107 @default.
• W3018489634 hasRelatedWork W2030135333 @default.
• W3018489634 hasRelatedWork W2037001212 @default.
• W3018489634 hasRelatedWork W2157644862 @default.
• W3018489634 hasRelatedWork W2579230892 @default.
• W3018489634 hasRelatedWork W2597074004 @default.
• W3018489634 hasRelatedWork W2888422165 @default.
• W3018489634 hasRelatedWork W3009495596 @default.

• next