Matches in SemOpenAlex for { <https://semopenalex.org/work/W3018520061> ?p ?o ?g. }
- W3018520061 abstract "Abstract Alcohol consumption is a consistent protective factor for the development of autoimmune diseases such as rheumatoid arthritis (RA). The underlying mechanism for this tolerance-inducing effect of alcohol, however, is unknown. Here we show that alcohol and its metabolite acetate alter the functional state of T follicular helper (T FH ) cells in vitro and in vivo, thereby exerting immune regulatory and tolerance-inducing properties. Alcohol-exposed mice have reduced Bcl6 and PD-1 expression as well as IL-21 production by T FH cells, preventing proper spatial organization of T FH cells to form T FH :B cell conjugates in germinal centers. This effect is associated with impaired autoantibody formation, and mitigates experimental autoimmune arthritis. By contrast, T cell independent immune responses and passive models of arthritis are not affected by alcohol exposure. These data clarify the immune regulatory and tolerance-inducing effect of alcohol consumption." @default.
- W3018520061 created "2020-05-01" @default.
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- W3018520061 date "2020-04-24" @default.
- W3018520061 modified "2023-10-16" @default.
- W3018520061 title "Ethanol consumption inhibits TFH cell responses and the development of autoimmune arthritis" @default.
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- W3018520061 doi "https://doi.org/10.1038/s41467-020-15855-z" @default.
- W3018520061 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7181688" @default.