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- W3018526463 abstract "We have shown that oligosaccharide supplementation can modulate the gut flora in neonates, and the microbiome is known to drive the maturation of the enteric glial cell (EGC) network postnatally. Here, we test the effects of dietary oligosaccharides on postnatal changes in the EGC network and intestinal morphology in a neonatal pig model.After suckling colostrum for 24-hours, one-day-old pigs were grouped onto one of three formula-based diets: control, high oligosaccharide (1:1 mixture of galactooligosaccharide and polydextrose, 8g/L), or low oligosaccharide (4g/L). Small intestine and colon samples were collected at 1- 7- 14- and 21- days-of-age for western blot and histological analysis. Preliminary histological results indicate a trend toward a decreased small intestinal villus length in the high oligosaccharide group at 7-days-of-age, indicative of accelerated intestinal maturity. Expression of the EGC marker glial fibrillary acidic protein is increased in the small intestinal mucosa at 7- and 14-days-of-age in the high oligosaccharide group based on a preliminary western blot (n=1). Following ongoing work to assess crypt morphology and quantify additional EGC markers S100B, PLP-1, Sox10 in the small intestine and colon, we expect to find increased mucosal expression of EGC markers earlier in postnatal development in the high oligosaccharide group, as well as histological changes consistent with enhanced rates of gut maturation in pigs fed a high oligosaccharide diet. Understanding how dietary inputs drive intestinal development postnatally may improve practices for managing optimal gut heath early in life. Support or Funding Information NIH K01 OD 028207, NIH P30 DK 034987, NIH-NICHD R01 HD095876, USDA-NIFA VMCG-0065" @default.
- W3018526463 created "2020-05-01" @default.
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- W3018526463 date "2020-04-01" @default.
- W3018526463 modified "2023-09-25" @default.
- W3018526463 title "Effects of Oligosaccharide Supplementation on Intestinal Morphology and Enteric Glial Cell Marker Expression in a Neonatal Pig Model" @default.
- W3018526463 doi "https://doi.org/10.1096/fasebj.2020.34.s1.09457" @default.
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