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• W3018558787 abstract "The aim of this study was to overcome the reported shortcomings of the glutathione (GSH) detection of rhodamine-based fluorescent probes, such as poor selectivity to thiol groups and reversible unstable covalent binding with the thiol groups. Here, we have developed a simple and specific fluorescent probe based on rhodamine B, which can be used to selectively detect GSH in solution and perform bioimaging in living cells. This design strategy uses a specific reaction between allenamide and the GSH thiol group, which proceeds rapidly in a phosphate buffer/tetrahydrofuran (PBS/THF) mixture with specific selectivity, and forms a stable and irreversible conjugate. The combined simplicity and specificity of the recognition process enables it to serve as a fluorescent probe for detecting GSH level changes in living cells. Such a new recognizing strategy thus may open a new window for its further application in detecting GSH levels both in vitro and in vivo." @default.
• W3018558787 created "2020-05-01" @default.
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• W3018558787 date "2020-01-01" @default.
• W3018558787 modified "2023-10-15" @default.
• W3018558787 title "A novel strategy for rhodamine B-based fluorescent probes with a selective glutathione response for bioimaging in living cells" @default.
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• W3018558787 doi "https://doi.org/10.1039/d0an00582g" @default.
• W3018558787 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32436498" @default.
• W3018558787 hasPublicationYear "2020" @default.
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