Matches in SemOpenAlex for { <https://semopenalex.org/work/W3018586675> ?p ?o ?g. }
- W3018586675 abstract "Abstract Classical dendritic cells (cDCs) are rare sentinel cells specialized in the regulation of adaptive immunity. Modeling cDC development is crucial to study cDCs and harness their therapeutic potential. Here we address whether cDCs could differentiate in response to trophic cues delivered by mesenchymal components of the hematopoietic niche. We find that mesenchymal stromal cells engineered to express membrane-bound FLT3L and stem cell factor (SCF) together with CXCL12 induce the specification of human cDCs from CD34 + hematopoietic stem and progenitor cells (HSPCs). Engraftment of engineered mesenchymal stromal cells (eMSCs) together with CD34 + HSPCs creates an in vivo synthetic niche in the dermis of immunodeficient mice driving the differentiation of cDCs and CD123 + AXL + CD327 + pre/AS-DCs. cDC2s generated in vivo display higher levels of resemblance with human blood cDCs unattained by in vitro-generated subsets. Altogether, eMSCs provide a unique platform recapitulating the full spectrum of cDC subsets enabling their functional characterization in vivo." @default.
- W3018586675 created "2020-05-01" @default.
- W3018586675 creator A5008273299 @default.
- W3018586675 creator A5013013357 @default.
- W3018586675 creator A5019955649 @default.
- W3018586675 creator A5026436234 @default.
- W3018586675 creator A5027444394 @default.
- W3018586675 creator A5044978234 @default.
- W3018586675 creator A5045293467 @default.
- W3018586675 creator A5053777631 @default.
- W3018586675 creator A5060666271 @default.
- W3018586675 creator A5064741298 @default.
- W3018586675 creator A5065110287 @default.
- W3018586675 creator A5075973125 @default.
- W3018586675 date "2020-04-28" @default.
- W3018586675 modified "2023-09-30" @default.
- W3018586675 title "Engineered niches support the development of human dendritic cells in humanized mice" @default.
- W3018586675 cites W1589080607 @default.
- W3018586675 cites W1661544713 @default.
- W3018586675 cites W1689372518 @default.
- W3018586675 cites W1979345147 @default.
- W3018586675 cites W1980942129 @default.
- W3018586675 cites W1981858801 @default.
- W3018586675 cites W1997384271 @default.
- W3018586675 cites W2000927180 @default.
- W3018586675 cites W2007987850 @default.
- W3018586675 cites W2012056552 @default.
- W3018586675 cites W2014035331 @default.
- W3018586675 cites W2018420076 @default.
- W3018586675 cites W2019546595 @default.
- W3018586675 cites W2036138390 @default.
- W3018586675 cites W2037224058 @default.
- W3018586675 cites W2038426170 @default.
- W3018586675 cites W2041357218 @default.
- W3018586675 cites W2052221015 @default.
- W3018586675 cites W2052730253 @default.
- W3018586675 cites W2070503238 @default.
- W3018586675 cites W2084403455 @default.
- W3018586675 cites W2089187782 @default.
- W3018586675 cites W2090685407 @default.
- W3018586675 cites W2091403646 @default.
- W3018586675 cites W2091525085 @default.
- W3018586675 cites W2095085751 @default.
- W3018586675 cites W2101014100 @default.
- W3018586675 cites W2101037339 @default.
- W3018586675 cites W2101595031 @default.
- W3018586675 cites W2101758099 @default.
- W3018586675 cites W2106883237 @default.
- W3018586675 cites W2108886544 @default.
- W3018586675 cites W2110974754 @default.
- W3018586675 cites W2113747277 @default.
- W3018586675 cites W2113896298 @default.
- W3018586675 cites W2116673455 @default.
- W3018586675 cites W2116763454 @default.
- W3018586675 cites W2120315525 @default.
- W3018586675 cites W2121236896 @default.
- W3018586675 cites W2126705611 @default.
- W3018586675 cites W2127144270 @default.
- W3018586675 cites W2130410032 @default.
- W3018586675 cites W2131761283 @default.
- W3018586675 cites W2133867101 @default.
- W3018586675 cites W2135200515 @default.
- W3018586675 cites W2138165953 @default.
- W3018586675 cites W2141925741 @default.
- W3018586675 cites W2142084466 @default.
- W3018586675 cites W2144829409 @default.
- W3018586675 cites W2144980184 @default.
- W3018586675 cites W2150780552 @default.
- W3018586675 cites W2151014102 @default.
- W3018586675 cites W2156831625 @default.
- W3018586675 cites W2161354474 @default.
- W3018586675 cites W2161472648 @default.
- W3018586675 cites W2168248700 @default.
- W3018586675 cites W2168401979 @default.
- W3018586675 cites W2169324807 @default.
- W3018586675 cites W2169456326 @default.
- W3018586675 cites W2170933182 @default.
- W3018586675 cites W2179438025 @default.
- W3018586675 cites W2271750147 @default.
- W3018586675 cites W2556671754 @default.
- W3018586675 cites W2572253813 @default.
- W3018586675 cites W2605810679 @default.
- W3018586675 cites W2674242699 @default.
- W3018586675 cites W2736397295 @default.
- W3018586675 cites W2773232299 @default.
- W3018586675 cites W2796897898 @default.
- W3018586675 cites W2803822216 @default.
- W3018586675 cites W2885298105 @default.
- W3018586675 cites W2887504455 @default.
- W3018586675 cites W2889326414 @default.
- W3018586675 cites W2970751796 @default.
- W3018586675 cites W4230096730 @default.
- W3018586675 cites W78744612 @default.
- W3018586675 doi "https://doi.org/10.1038/s41467-020-15937-y" @default.
- W3018586675 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7189247" @default.
- W3018586675 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32345968" @default.
- W3018586675 hasPublicationYear "2020" @default.
- W3018586675 type Work @default.
- W3018586675 sameAs 3018586675 @default.
- W3018586675 citedByCount "19" @default.