Matches in SemOpenAlex for { <https://semopenalex.org/work/W3018595823> ?p ?o ?g. }
- W3018595823 abstract "Abstract Type 1 diabetes (T1D) is an autoimmune disease in which insulin-producing pancreatic β-cells are destroyed. Intestinal helminths can cause asymptomatic chronic and immunosuppressive infections and suppress disease in rodent models of T1D. However, the underlying regulatory mechanisms for this protection are unclear. Here, we report that CD8 + regulatory T (Treg) cells prevent the onset of streptozotocin -induced diabetes by a rodent intestinal nematode. Trehalose derived from nematodes affects the intestinal microbiota and increases the abundance of Ruminococcus spp., resulting in the induction of CD8 + Treg cells. Furthermore, trehalose has therapeutic effects on both streptozotocin-induced diabetes and in the NOD mouse model of T1D. In addition, compared with healthy volunteers, patients with T1D have fewer CD8 + Treg cells, and the abundance of intestinal Ruminococcus positively correlates with the number of CD8 + Treg cells in humans." @default.
- W3018595823 created "2020-05-01" @default.
- W3018595823 creator A5002489205 @default.
- W3018595823 creator A5006932569 @default.
- W3018595823 creator A5011821552 @default.
- W3018595823 creator A5015501925 @default.
- W3018595823 creator A5019631374 @default.
- W3018595823 creator A5024316557 @default.
- W3018595823 creator A5028348296 @default.
- W3018595823 creator A5029489298 @default.
- W3018595823 creator A5030074986 @default.
- W3018595823 creator A5031801047 @default.
- W3018595823 creator A5047452461 @default.
- W3018595823 creator A5050525360 @default.
- W3018595823 creator A5068801482 @default.
- W3018595823 creator A5074965316 @default.
- W3018595823 creator A5084232644 @default.
- W3018595823 date "2020-04-22" @default.
- W3018595823 modified "2023-10-17" @default.
- W3018595823 title "CD8+ regulatory T cells are critical in prevention of autoimmune-mediated diabetes" @default.
- W3018595823 cites W1575489109 @default.
- W3018595823 cites W1729698063 @default.
- W3018595823 cites W1809561724 @default.
- W3018595823 cites W1969582479 @default.
- W3018595823 cites W1970868994 @default.
- W3018595823 cites W1992445331 @default.
- W3018595823 cites W1998572804 @default.
- W3018595823 cites W1999906527 @default.
- W3018595823 cites W2000673348 @default.
- W3018595823 cites W2020697796 @default.
- W3018595823 cites W2033239478 @default.
- W3018595823 cites W2037798159 @default.
- W3018595823 cites W2038100201 @default.
- W3018595823 cites W2047307433 @default.
- W3018595823 cites W2057588398 @default.
- W3018595823 cites W2064426162 @default.
- W3018595823 cites W2073983079 @default.
- W3018595823 cites W2075436742 @default.
- W3018595823 cites W2078329315 @default.
- W3018595823 cites W2100930848 @default.
- W3018595823 cites W2102473693 @default.
- W3018595823 cites W2103992462 @default.
- W3018595823 cites W2110188726 @default.
- W3018595823 cites W2111731663 @default.
- W3018595823 cites W2111896604 @default.
- W3018595823 cites W2117457769 @default.
- W3018595823 cites W2136798761 @default.
- W3018595823 cites W2138947021 @default.
- W3018595823 cites W2148067809 @default.
- W3018595823 cites W2151178653 @default.
- W3018595823 cites W2164386968 @default.
- W3018595823 cites W2169733549 @default.
- W3018595823 cites W2170075617 @default.
- W3018595823 cites W2272650560 @default.
- W3018595823 cites W2337621927 @default.
- W3018595823 cites W2345813655 @default.
- W3018595823 cites W2411494581 @default.
- W3018595823 cites W2573636906 @default.
- W3018595823 cites W2615856274 @default.
- W3018595823 cites W2766405184 @default.
- W3018595823 doi "https://doi.org/10.1038/s41467-020-15857-x" @default.
- W3018595823 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7176710" @default.
- W3018595823 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32321922" @default.
- W3018595823 hasPublicationYear "2020" @default.
- W3018595823 type Work @default.
- W3018595823 sameAs 3018595823 @default.
- W3018595823 citedByCount "55" @default.
- W3018595823 countsByYear W30185958232020 @default.
- W3018595823 countsByYear W30185958232021 @default.
- W3018595823 countsByYear W30185958232022 @default.
- W3018595823 countsByYear W30185958232023 @default.
- W3018595823 crossrefType "journal-article" @default.
- W3018595823 hasAuthorship W3018595823A5002489205 @default.
- W3018595823 hasAuthorship W3018595823A5006932569 @default.
- W3018595823 hasAuthorship W3018595823A5011821552 @default.
- W3018595823 hasAuthorship W3018595823A5015501925 @default.
- W3018595823 hasAuthorship W3018595823A5019631374 @default.
- W3018595823 hasAuthorship W3018595823A5024316557 @default.
- W3018595823 hasAuthorship W3018595823A5028348296 @default.
- W3018595823 hasAuthorship W3018595823A5029489298 @default.
- W3018595823 hasAuthorship W3018595823A5030074986 @default.
- W3018595823 hasAuthorship W3018595823A5031801047 @default.
- W3018595823 hasAuthorship W3018595823A5047452461 @default.
- W3018595823 hasAuthorship W3018595823A5050525360 @default.
- W3018595823 hasAuthorship W3018595823A5068801482 @default.
- W3018595823 hasAuthorship W3018595823A5074965316 @default.
- W3018595823 hasAuthorship W3018595823A5084232644 @default.
- W3018595823 hasBestOaLocation W30185958231 @default.
- W3018595823 hasConcept C126322002 @default.
- W3018595823 hasConcept C134018914 @default.
- W3018595823 hasConcept C167672396 @default.
- W3018595823 hasConcept C203014093 @default.
- W3018595823 hasConcept C2776090121 @default.
- W3018595823 hasConcept C2778013207 @default.
- W3018595823 hasConcept C2778296632 @default.
- W3018595823 hasConcept C2779134260 @default.
- W3018595823 hasConcept C2779280383 @default.
- W3018595823 hasConcept C2780027724 @default.
- W3018595823 hasConcept C2780130043 @default.
- W3018595823 hasConcept C2781232474 @default.