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- W3018601919 abstract "Phyllanthus emblica (P. emblica) is a traditionally edible fruit that is good for treatment of biliary diseases, bronchitis, etc. It has obvious anti-inflammatory activity, but few studies focus on its anti-inflammatory active substance basis. The purpose of this study was to explore the material basis of anti-inflammatory activity of P. emblica, purify, and identify anti-inflammatory active monomers. Fisetin and gallic acid, which were identified after separation from ethanol extract components of P. emblica, exhibited the best anti-inflammatory effects, markedly inhibiting nitric oxide and proinflammatory cytokine levels in LPS-stimulated macrophages. In particular, fisetin with significant anti-inflammatory activity was firstly identified from P. emblica. For the first time, our research systematically revealed the material basis of the anti-inflammatory effects of P. emblica from the perspective of the composition of the bioactive substances and provided scientific research methods and ideas for researching bioactive monomers in other plant extracts." @default.
- W3018601919 created "2020-05-01" @default.
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- W3018601919 date "2020-04-22" @default.
- W3018601919 modified "2023-10-13" @default.
- W3018601919 title "Bioactivity‐guided isolation of anti‐inflammatory components from <i>Phyllanthus emblica</i>" @default.
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- W3018601919 doi "https://doi.org/10.1002/fsn3.1553" @default.
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