FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3018637709> ?p ?o ?g. }

• W3018637709 endingPage "998" @default.
• W3018637709 startingPage "989" @default.
• W3018637709 abstract "Background: Peroxynitrite, a nitrating and oxidizing agent, is formed by the interaction between nitric oxide and superoxide radicals. H2A histone is a basic nucleoprotein and is one of the major core histones responsible for packaging DNA. It has been shown that they are highly sensitive to oxidizing and nitrating agents. Objective: Nitration of tyrosine residues in proteins by peroxynitrite is regarded as a marker of nitrosative damage. The dityrosine bond, an oxidative covalent cross-link between two tyrosines in protein, is increasingly identified as a marker of oxidative stress, aging and neurodegerative diseases. Methods: Peroxinitrite-mediated nitration and dinitration in H2A histone was assessed by various biophysical techniques. Results: The data presented in this study showed that the dityrosine content was found to be elevated in H2A histone modified with peroxynitrite. The formation of dityrosine showed a decrease in fluorescence intensity, generation of a new peak in FT-IR, increase in hydrodynamic size, and loss of secondary and tertiary structure of H2A resulting in a partially folded structure. Conclusion: We report that H2A may undergo conformational and structural changes under nitrosative and oxidative stress from the deleterious effects of peroxynitrite." @default.
• W3018637709 created "2020-05-01" @default.
• W3018637709 creator A5027178689 @default.
• W3018637709 creator A5038861653 @default.
• W3018637709 creator A5042446340 @default.
• W3018637709 creator A5058640631 @default.
• W3018637709 creator A5087611465 @default.
• W3018637709 date "2020-11-02" @default.
• W3018637709 modified "2023-10-16" @default.
• W3018637709 title "Peroxynitrite-Mediated Structural Changes in Histone H2A: Biochemical and Biophysical Analysis" @default.
• W3018637709 cites W1587532579 @default.
• W3018637709 cites W1589162257 @default.
• W3018637709 cites W1856132172 @default.
• W3018637709 cites W1965518852 @default.
• W3018637709 cites W1967274652 @default.
• W3018637709 cites W1970711821 @default.
• W3018637709 cites W1982251931 @default.
• W3018637709 cites W1985841329 @default.
• W3018637709 cites W1986046103 @default.
• W3018637709 cites W1986787846 @default.
• W3018637709 cites W1988535831 @default.
• W3018637709 cites W1999589434 @default.
• W3018637709 cites W2005127542 @default.
• W3018637709 cites W2010048885 @default.
• W3018637709 cites W2015444280 @default.
• W3018637709 cites W2019859522 @default.
• W3018637709 cites W2023761623 @default.
• W3018637709 cites W2025225742 @default.
• W3018637709 cites W2031987411 @default.
• W3018637709 cites W2038443620 @default.
• W3018637709 cites W2041834967 @default.
• W3018637709 cites W2050863140 @default.
• W3018637709 cites W2055805017 @default.
• W3018637709 cites W2058137293 @default.
• W3018637709 cites W2060545093 @default.
• W3018637709 cites W2062228103 @default.
• W3018637709 cites W2064053352 @default.
• W3018637709 cites W2070213522 @default.
• W3018637709 cites W2078528113 @default.
• W3018637709 cites W2079711912 @default.
• W3018637709 cites W2089082619 @default.
• W3018637709 cites W2121538550 @default.
• W3018637709 cites W2129995310 @default.
• W3018637709 cites W2141352921 @default.
• W3018637709 cites W2144792857 @default.
• W3018637709 cites W2149655280 @default.
• W3018637709 cites W268238884 @default.
• W3018637709 cites W2756324351 @default.
• W3018637709 cites W2787052956 @default.
• W3018637709 cites W2792351762 @default.
• W3018637709 doi "https://doi.org/10.2174/0929866527666200427213722" @default.
• W3018637709 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32342801" @default.
• W3018637709 hasPublicationYear "2020" @default.
• W3018637709 type Work @default.
• W3018637709 sameAs 3018637709 @default.
• W3018637709 citedByCount "2" @default.
• W3018637709 countsByYear W30186377092021 @default.
• W3018637709 countsByYear W30186377092022 @default.
• W3018637709 crossrefType "journal-article" @default.
• W3018637709 hasAuthorship W3018637709A5027178689 @default.
• W3018637709 hasAuthorship W3018637709A5038861653 @default.
• W3018637709 hasAuthorship W3018637709A5042446340 @default.
• W3018637709 hasAuthorship W3018637709A5058640631 @default.
• W3018637709 hasAuthorship W3018637709A5087611465 @default.
• W3018637709 hasConcept C12554922 @default.
• W3018637709 hasConcept C178790620 @default.
• W3018637709 hasConcept C181199279 @default.
• W3018637709 hasConcept C185592680 @default.
• W3018637709 hasConcept C2775856698 @default.
• W3018637709 hasConcept C2776151105 @default.
• W3018637709 hasConcept C2777622882 @default.
• W3018637709 hasConcept C2778784160 @default.
• W3018637709 hasConcept C2779385521 @default.
• W3018637709 hasConcept C2780795997 @default.
• W3018637709 hasConcept C2911203004 @default.
• W3018637709 hasConcept C3020296196 @default.
• W3018637709 hasConcept C519581460 @default.
• W3018637709 hasConcept C552990157 @default.
• W3018637709 hasConcept C55493867 @default.
• W3018637709 hasConcept C57600042 @default.
• W3018637709 hasConcept C64927066 @default.
• W3018637709 hasConcept C86803240 @default.
• W3018637709 hasConceptScore W3018637709C12554922 @default.
• W3018637709 hasConceptScore W3018637709C178790620 @default.
• W3018637709 hasConceptScore W3018637709C181199279 @default.
• W3018637709 hasConceptScore W3018637709C185592680 @default.
• W3018637709 hasConceptScore W3018637709C2775856698 @default.
• W3018637709 hasConceptScore W3018637709C2776151105 @default.
• W3018637709 hasConceptScore W3018637709C2777622882 @default.
• W3018637709 hasConceptScore W3018637709C2778784160 @default.
• W3018637709 hasConceptScore W3018637709C2779385521 @default.
• W3018637709 hasConceptScore W3018637709C2780795997 @default.
• W3018637709 hasConceptScore W3018637709C2911203004 @default.
• W3018637709 hasConceptScore W3018637709C3020296196 @default.
• W3018637709 hasConceptScore W3018637709C519581460 @default.
• W3018637709 hasConceptScore W3018637709C552990157 @default.
• W3018637709 hasConceptScore W3018637709C55493867 @default.
• W3018637709 hasConceptScore W3018637709C57600042 @default.

• next