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- W3018679920 endingPage "iii27" @default.
- W3018679920 startingPage "iii17" @default.
- W3018679920 abstract "Abstract For decades, the treatment of GCA has relied on glucocorticoids. Work over the past two decades has supported a modest efficacy of MTX but no clear benefit from anti-TNF-based therapies. More recently, the therapeutic armamentarium for GCA has expanded. The availability of agents targeting specific cytokines, cytokine receptors or signalling pathways, along with a better, although still limited, understanding of the immunopathology of GCA, are opening further therapeutic possibilities. Blocking IL-6 receptor with tocilizumab has been effective in maintaining remission and reducing glucocorticoid exposure and tocilizumab has been approved for the treatment of GCA. However, nearly half of the patients do not benefit from tocilizumab and additional options need to be investigated. This review focuses on standard therapeutic approaches and on targeted therapies that have been or are currently under investigation." @default.
- W3018679920 created "2020-05-01" @default.
- W3018679920 creator A5000989837 @default.
- W3018679920 creator A5028626675 @default.
- W3018679920 creator A5044632715 @default.
- W3018679920 creator A5059764745 @default.
- W3018679920 date "2020-04-29" @default.
- W3018679920 modified "2023-10-09" @default.
- W3018679920 title "Treatment of giant-cell arteritis: from broad spectrum immunosuppressive agents to targeted therapies" @default.
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- W3018679920 doi "https://doi.org/10.1093/rheumatology/kez645" @default.