Matches in SemOpenAlex for { <https://semopenalex.org/work/W3018823230> ?p ?o ?g. }
- W3018823230 endingPage "179" @default.
- W3018823230 startingPage "159" @default.
- W3018823230 abstract "Human malaria is a pathogenic disease mainly caused by Plasmodium falciparum, which was responsible for about 405,000 deaths globally in the year 2018. To date, several vaccine candidates have been evaluated for prevention, which failed to produce optimal output at various preclinical/clinical stages. This study is based on designing of polypeptide vaccines (PVs) against human malaria that cover almost all stages of life-cycle of Plasmodium and for the same 5 genome derived predicted antigenic proteins (GDPAP) have been used. For the development of a multi-immune inducer, 15 PVs were initially designed using T-cell epitope ensemble, which covered >99% human population as well as linear B-cell epitopes with or without adjuvants. The immune simulation of PVs showed higher levels of T-cell and B-cell activities compared to positive and negative vaccine controls. Furthermore, in silico cloning of PVs and codon optimization followed by enhanced expression within Lactococcus lactis host system was also explored. Although, the study has sound theoretical and in silico findings, the in vitro/in vivo evaluation seems imperative to warrant the immunogenicity and safety of PVs towards management of P. falciparum infection in the future." @default.
- W3018823230 created "2020-05-01" @default.
- W3018823230 creator A5019018404 @default.
- W3018823230 creator A5034194890 @default.
- W3018823230 creator A5043541023 @default.
- W3018823230 creator A5070710258 @default.
- W3018823230 creator A5075566188 @default.
- W3018823230 creator A5087473918 @default.
- W3018823230 date "2020-09-01" @default.
- W3018823230 modified "2023-10-16" @default.
- W3018823230 title "A cutting-edge immunoinformatics approach for design of multi-epitope oral vaccine against dreadful human malaria" @default.
- W3018823230 cites W108224684 @default.
- W3018823230 cites W1565974182 @default.
- W3018823230 cites W1651271348 @default.
- W3018823230 cites W1869576842 @default.
- W3018823230 cites W1927805349 @default.
- W3018823230 cites W1963017213 @default.
- W3018823230 cites W1964594321 @default.
- W3018823230 cites W1967117573 @default.
- W3018823230 cites W1967351936 @default.
- W3018823230 cites W1968159209 @default.
- W3018823230 cites W1976316617 @default.
- W3018823230 cites W1977455495 @default.
- W3018823230 cites W1977465237 @default.
- W3018823230 cites W1978790143 @default.
- W3018823230 cites W1982293312 @default.
- W3018823230 cites W1986191025 @default.
- W3018823230 cites W1988966248 @default.
- W3018823230 cites W1991773233 @default.
- W3018823230 cites W1994942139 @default.
- W3018823230 cites W2004773897 @default.
- W3018823230 cites W2006295948 @default.
- W3018823230 cites W2008504678 @default.
- W3018823230 cites W2013232647 @default.
- W3018823230 cites W2020111407 @default.
- W3018823230 cites W2023218619 @default.
- W3018823230 cites W2025190578 @default.
- W3018823230 cites W2025662227 @default.
- W3018823230 cites W2035240910 @default.
- W3018823230 cites W2040299410 @default.
- W3018823230 cites W2040545420 @default.
- W3018823230 cites W2041556389 @default.
- W3018823230 cites W2043937662 @default.
- W3018823230 cites W2056140371 @default.
- W3018823230 cites W2057021995 @default.
- W3018823230 cites W2057289558 @default.
- W3018823230 cites W2061647899 @default.
- W3018823230 cites W2068361619 @default.
- W3018823230 cites W2074986801 @default.
- W3018823230 cites W2075666223 @default.
- W3018823230 cites W2075817888 @default.
- W3018823230 cites W2081147529 @default.
- W3018823230 cites W2081555185 @default.
- W3018823230 cites W2090211342 @default.
- W3018823230 cites W2090564296 @default.
- W3018823230 cites W2096354903 @default.
- W3018823230 cites W2101340968 @default.
- W3018823230 cites W2105422109 @default.
- W3018823230 cites W2120403054 @default.
- W3018823230 cites W2122256714 @default.
- W3018823230 cites W2124672930 @default.
- W3018823230 cites W2125093561 @default.
- W3018823230 cites W2126946980 @default.
- W3018823230 cites W2129186216 @default.
- W3018823230 cites W2130145174 @default.
- W3018823230 cites W2134671775 @default.
- W3018823230 cites W2142748660 @default.
- W3018823230 cites W2145216692 @default.
- W3018823230 cites W2148780611 @default.
- W3018823230 cites W2149639160 @default.
- W3018823230 cites W2156731388 @default.
- W3018823230 cites W2157427941 @default.
- W3018823230 cites W2157801980 @default.
- W3018823230 cites W2161440397 @default.
- W3018823230 cites W2163861382 @default.
- W3018823230 cites W2166637863 @default.
- W3018823230 cites W2168036974 @default.
- W3018823230 cites W2168341480 @default.
- W3018823230 cites W2169656611 @default.
- W3018823230 cites W2217812638 @default.
- W3018823230 cites W2287500273 @default.
- W3018823230 cites W2323929490 @default.
- W3018823230 cites W2395403452 @default.
- W3018823230 cites W2467449187 @default.
- W3018823230 cites W2472994826 @default.
- W3018823230 cites W2494438678 @default.
- W3018823230 cites W2538319129 @default.
- W3018823230 cites W2562638954 @default.
- W3018823230 cites W2562930371 @default.
- W3018823230 cites W2582692751 @default.
- W3018823230 cites W2586246990 @default.
- W3018823230 cites W2589374924 @default.
- W3018823230 cites W2617066807 @default.
- W3018823230 cites W2734658056 @default.
- W3018823230 cites W2739307655 @default.
- W3018823230 cites W2740657077 @default.
- W3018823230 cites W2744401611 @default.
- W3018823230 cites W2748834817 @default.