Matches in SemOpenAlex for { <https://semopenalex.org/work/W3018900532> ?p ?o ?g. }
- W3018900532 endingPage "578" @default.
- W3018900532 startingPage "570" @default.
- W3018900532 abstract "The saphenous vein is the most commonly used bypass graft in patients with coronary artery disease. During routine coronary artery bypass, grafting the vascular damage inflicted on the vein is likely to stimulate the release of endothelin-1, a potent endothelium-derived vasoconstrictor that also possesses cell proliferation and inflammatory properties, conditions associated with vein graft failure. In both in vitro and in vivo studies, endothelin receptor antagonists reduce neointimal thickening. The mechanisms underlying these observations are multifactorial and include an effect on cell proliferation and cell/tissue damage. Much of the data supporting the beneficial action of endothelin-1 receptor antagonism at reducing intimal thickening and occlusion in experimental vein grafts were published over 20 years ago. The theme of the recent ET-16 conference in Kobe was “Visiting Old and Learning New”. This short review article provides an overview of studies showing the potential of endothelin receptor antagonists to offer an adjuvant therapeutic approach for reducing saphenous vein graft failure and poses the question why this important area of research has not been translated from bench to bedside given the potential benefit for coronary artery bypass patients." @default.
- W3018900532 created "2020-05-01" @default.
- W3018900532 creator A5040763960 @default.
- W3018900532 creator A5077915447 @default.
- W3018900532 date "2020-09-01" @default.
- W3018900532 modified "2023-09-26" @default.
- W3018900532 title "Endothelin-1, endothelin receptor antagonists, and vein graft occlusion in coronary artery bypass surgery: 20 years on and still no journey from bench to bedside" @default.
- W3018900532 cites W1485386970 @default.
- W3018900532 cites W1533086133 @default.
- W3018900532 cites W1542924658 @default.
- W3018900532 cites W1964549548 @default.
- W3018900532 cites W1969711591 @default.
- W3018900532 cites W1973839592 @default.
- W3018900532 cites W1975755648 @default.
- W3018900532 cites W1977513074 @default.
- W3018900532 cites W1977794018 @default.
- W3018900532 cites W1985833668 @default.
- W3018900532 cites W1986070439 @default.
- W3018900532 cites W1987260202 @default.
- W3018900532 cites W1997592986 @default.
- W3018900532 cites W1998540497 @default.
- W3018900532 cites W2003196651 @default.
- W3018900532 cites W2007006539 @default.
- W3018900532 cites W2019432437 @default.
- W3018900532 cites W2020355200 @default.
- W3018900532 cites W2020513024 @default.
- W3018900532 cites W2020819292 @default.
- W3018900532 cites W2023195079 @default.
- W3018900532 cites W2025252445 @default.
- W3018900532 cites W2026980150 @default.
- W3018900532 cites W2031634631 @default.
- W3018900532 cites W2034628419 @default.
- W3018900532 cites W2037492971 @default.
- W3018900532 cites W2038012085 @default.
- W3018900532 cites W2038188017 @default.
- W3018900532 cites W2042274135 @default.
- W3018900532 cites W2049010318 @default.
- W3018900532 cites W2050530109 @default.
- W3018900532 cites W2056387044 @default.
- W3018900532 cites W2058053947 @default.
- W3018900532 cites W2060336882 @default.
- W3018900532 cites W2077375838 @default.
- W3018900532 cites W2078120099 @default.
- W3018900532 cites W2084935848 @default.
- W3018900532 cites W2085973231 @default.
- W3018900532 cites W2088611940 @default.
- W3018900532 cites W2094759820 @default.
- W3018900532 cites W2094852775 @default.
- W3018900532 cites W2104343492 @default.
- W3018900532 cites W2105256775 @default.
- W3018900532 cites W2110809908 @default.
- W3018900532 cites W2124110375 @default.
- W3018900532 cites W2124874264 @default.
- W3018900532 cites W2132931180 @default.
- W3018900532 cites W2143563121 @default.
- W3018900532 cites W2146046550 @default.
- W3018900532 cites W2148692835 @default.
- W3018900532 cites W2150108723 @default.
- W3018900532 cites W2153023405 @default.
- W3018900532 cites W2162651746 @default.
- W3018900532 cites W2162804111 @default.
- W3018900532 cites W2256290157 @default.
- W3018900532 cites W2283495751 @default.
- W3018900532 cites W2298417091 @default.
- W3018900532 cites W2317121661 @default.
- W3018900532 cites W2321079144 @default.
- W3018900532 cites W2415367732 @default.
- W3018900532 cites W2530856099 @default.
- W3018900532 cites W2623279330 @default.
- W3018900532 cites W2784484344 @default.
- W3018900532 cites W2920491490 @default.
- W3018900532 cites W2921688102 @default.
- W3018900532 cites W2968603864 @default.
- W3018900532 cites W2983063065 @default.
- W3018900532 cites W4210343616 @default.
- W3018900532 cites W1998275697 @default.
- W3018900532 doi "https://doi.org/10.1139/cjpp-2019-0598" @default.
- W3018900532 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32343914" @default.
- W3018900532 hasPublicationYear "2020" @default.
- W3018900532 type Work @default.
- W3018900532 sameAs 3018900532 @default.
- W3018900532 citedByCount "4" @default.
- W3018900532 countsByYear W30189005322020 @default.
- W3018900532 countsByYear W30189005322021 @default.
- W3018900532 countsByYear W30189005322022 @default.
- W3018900532 countsByYear W30189005322023 @default.
- W3018900532 crossrefType "journal-article" @default.
- W3018900532 hasAuthorship W3018900532A5040763960 @default.
- W3018900532 hasAuthorship W3018900532A5077915447 @default.
- W3018900532 hasBestOaLocation W30189005322 @default.
- W3018900532 hasConcept C126322002 @default.
- W3018900532 hasConcept C141071460 @default.
- W3018900532 hasConcept C144980905 @default.
- W3018900532 hasConcept C164705383 @default.
- W3018900532 hasConcept C170493617 @default.
- W3018900532 hasConcept C2776820930 @default.
- W3018900532 hasConcept C2776992346 @default.
- W3018900532 hasConcept C2777202286 @default.