FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3018911280> ?p ?o ?g. }

• W3018911280 abstract "Abstract Cardiac levels of the signal transducer and activator of transcription factor-3 (STAT3) decline with age, and male but not female mice with a cardiomyocyte-specific STAT3 deficiency (CKO) display premature age-related heart failure associated with reduced cardiac capillary density. In the present study isolated male and female CKO-cardiomyocytes exhibit increased prostaglandin (PG)-generating cyclooxygenase-2 (COX-2) expression. The PG-degrading hydroxyprostaglandin-dehydrogenase-15 (HPGD) expression is only reduced in male cardiomyocytes, which is associated with increased PGD 2 secretion from isolated male but not female CKO-cardiomyocytes. Reduced HPGD expression in male cardiomyocytes derive from impaired androgen-receptor-(AR)-signaling due to loss of its co-factor STAT3. Elevated PGD 2 secretion in males is associated with increased white adipocyte accumulation in aged male but not female hearts. Adipocyte differentiation is enhanced in isolated SCA-1 + -cardiac-progenitor-cells (CPC) from young male CKO-mice compared to the adipocyte differentiation of male wildtype (WT)-CPC and CPC isolated from female mice. Epigenetic analysis in freshly isolated male CKO-CPC display hypermethylation in pro-angiogenic genes ( Fgfr2 , Epas1 ) and hypomethylation in the white adipocyte differentiation gene Zfp423 associated with upregulated ZFP423 expression and a shift from endothelial to white adipocyte differentiation compared to WT-CPC. The expression of the histone-methyltransferase EZH2 is reduced in male CKO-CPC compared to male WT-CPC whereas no differences in the EZH2 expression in female CPC were observed. Clonally expanded CPC can differentiate into endothelial cells or into adipocytes depending on the differentiation conditions. ZFP423 overexpression is sufficient to induce white adipocyte differentiation of clonal CPC. In isolated WT-CPC, PGD 2 stimulation reduces the expression of EZH2 thereby upregulating ZFP423 expression and promoting white adipocyte differentiation. Thus, cardiomyocyte STAT3-deficiency leads to age-related and sex-specific cardiac remodeling and failure in part due to sex-specific alterations in PGD 2 secretion and subsequent epigenetic impairment of the differentiation potential of CPC. Causally involved is the impaired AR signaling in absence of STAT3, which reduces the expression of the PG degrading enzyme HPGD." @default.
• W3018911280 created "2020-05-01" @default.
• W3018911280 creator A5000286275 @default.
• W3018911280 creator A5022378009 @default.
• W3018911280 creator A5032263710 @default.
• W3018911280 creator A5042647916 @default.
• W3018911280 creator A5048696331 @default.
• W3018911280 creator A5053832400 @default.
• W3018911280 creator A5057910314 @default.
• W3018911280 creator A5060414344 @default.
• W3018911280 creator A5061321087 @default.
• W3018911280 creator A5065734555 @default.
• W3018911280 creator A5066349732 @default.
• W3018911280 creator A5074416601 @default.
• W3018911280 creator A5084381587 @default.
• W3018911280 creator A5084386114 @default.
• W3018911280 date "2020-04-24" @default.
• W3018911280 modified "2023-09-27" @default.
• W3018911280 title "Increased prostaglandin-D2 in male but not female STAT3-deficient hearts shifts cardiac progenitor cells from endothelial to white adipocyte differentiation" @default.
• W3018911280 cites W1969241521 @default.
• W3018911280 cites W1978966324 @default.
• W3018911280 cites W1979090251 @default.
• W3018911280 cites W1987003028 @default.
• W3018911280 cites W1990937720 @default.
• W3018911280 cites W1991447679 @default.
• W3018911280 cites W1996956937 @default.
• W3018911280 cites W2000819127 @default.
• W3018911280 cites W2030982691 @default.
• W3018911280 cites W2036288752 @default.
• W3018911280 cites W2036897871 @default.
• W3018911280 cites W2040419432 @default.
• W3018911280 cites W2048748125 @default.
• W3018911280 cites W2053421436 @default.
• W3018911280 cites W2060935391 @default.
• W3018911280 cites W2061908858 @default.
• W3018911280 cites W2067394446 @default.
• W3018911280 cites W2068732521 @default.
• W3018911280 cites W2072969092 @default.
• W3018911280 cites W2074814691 @default.
• W3018911280 cites W2088404163 @default.
• W3018911280 cites W2088447803 @default.
• W3018911280 cites W2090535095 @default.
• W3018911280 cites W2098656972 @default.
• W3018911280 cites W2102619694 @default.
• W3018911280 cites W2113162775 @default.
• W3018911280 cites W2120384767 @default.
• W3018911280 cites W2122686130 @default.
• W3018911280 cites W2125416593 @default.
• W3018911280 cites W2125567855 @default.
• W3018911280 cites W2132124040 @default.
• W3018911280 cites W2141229724 @default.
• W3018911280 cites W2158804744 @default.
• W3018911280 cites W2183417521 @default.
• W3018911280 cites W2186978757 @default.
• W3018911280 cites W2291982250 @default.
• W3018911280 cites W2404171570 @default.
• W3018911280 cites W2551225596 @default.
• W3018911280 cites W2601054993 @default.
• W3018911280 cites W2614757888 @default.
• W3018911280 cites W2624678267 @default.
• W3018911280 cites W2749205090 @default.
• W3018911280 cites W2782360171 @default.
• W3018911280 cites W2783946086 @default.
• W3018911280 cites W2788776197 @default.
• W3018911280 cites W2804665662 @default.
• W3018911280 cites W2861366762 @default.
• W3018911280 cites W2897388509 @default.
• W3018911280 cites W2906598935 @default.
• W3018911280 cites W2912635732 @default.
• W3018911280 cites W2914092998 @default.
• W3018911280 cites W2916042189 @default.
• W3018911280 cites W2972618106 @default.
• W3018911280 cites W2977551462 @default.
• W3018911280 cites W2993468772 @default.
• W3018911280 cites W4237567990 @default.
• W3018911280 doi "https://doi.org/10.1101/2020.04.24.059287" @default.
• W3018911280 hasPublicationYear "2020" @default.
• W3018911280 type Work @default.
• W3018911280 sameAs 3018911280 @default.
• W3018911280 citedByCount "0" @default.
• W3018911280 crossrefType "posted-content" @default.
• W3018911280 hasAuthorship W3018911280A5000286275 @default.
• W3018911280 hasAuthorship W3018911280A5022378009 @default.
• W3018911280 hasAuthorship W3018911280A5032263710 @default.
• W3018911280 hasAuthorship W3018911280A5042647916 @default.
• W3018911280 hasAuthorship W3018911280A5048696331 @default.
• W3018911280 hasAuthorship W3018911280A5053832400 @default.
• W3018911280 hasAuthorship W3018911280A5057910314 @default.
• W3018911280 hasAuthorship W3018911280A5060414344 @default.
• W3018911280 hasAuthorship W3018911280A5061321087 @default.
• W3018911280 hasAuthorship W3018911280A5065734555 @default.
• W3018911280 hasAuthorship W3018911280A5066349732 @default.
• W3018911280 hasAuthorship W3018911280A5074416601 @default.
• W3018911280 hasAuthorship W3018911280A5084381587 @default.
• W3018911280 hasAuthorship W3018911280A5084386114 @default.
• W3018911280 hasBestOaLocation W30189112801 @default.
• W3018911280 hasConcept C126322002 @default.
• W3018911280 hasConcept C134018914 @default.
• W3018911280 hasConcept C171089720 @default.
• W3018911280 hasConcept C201750760 @default.

• next