FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3019021138> ?p ?o ?g. }

• W3019021138 endingPage "1650" @default.
• W3019021138 startingPage "1644" @default.
• W3019021138 abstract "Background Pulmonary gas exchange efficiency, determined by the alveolar-to-arterial Po2 difference (A-aDo2), progressively worsens during exercise at sea-level; this response is further elevated during exercise in hypoxia. Traditionally, pulmonary gas exchange efficiency is assessed through measurements of ventilation and end-tidal gases paired with direct arterial blood gas (ABG) sampling. Because these measures have a number of caveats, particularly invasive blood sampling, the development of new approaches for the noninvasive assessment of pulmonary gas exchange is needed. Research Question Is a noninvasive method of assessing pulmonary gas exchange valid during rest and exercise in acute hypoxia? Study Design and Methods Twenty-five healthy participants (10 female) completed a staged maximal exercise test on a cycle ergometer in a hypoxic chamber (Fio2 = 0.11). Simultaneous ABGs via a radial arterial catheter and noninvasive gas-exchange measurements (AGM100) were obtained in 2-minute intervals. Noninvasive gas exchange, termed the O2 deficit, was calculated from the difference between the end-tidal and the calculated Pao2 (via pulse oximetry and corrected for the Bohr effect by using the end-tidal Pco2). Noninvasive O2 deficit was compared with the traditional alveolar to arterial oxygen difference (A-aDo2), using the traditional Riley analysis. Results Under conditions of rest at room air, hypoxic rest, and hypoxic exercise, strong correlations between the calculated gPao2 and directly measured Pao2 (R2 = 0.97; P < .001; mean bias = 1.70 mm Hg) were observed. At hypoxic rest and exercise, strong relationships between the estimated and directly measured Pao2 (R2 = 0.68; P < .001; mean bias = 1.01 mm Hg) and O2 deficit with the traditional A-aDo2 (R2 = 0.70; P < .001; mean bias = 5.24 mm Hg) remained. Interpretations Our findings support the use of a noninvasive measure of gas exchange during acute hypoxic exercise in heathy humans. Further studies are required to determine whether this approach can be used clinically as a tool during normoxic exercise in patients with preexisting impairments in gas exchange efficiency. Pulmonary gas exchange efficiency, determined by the alveolar-to-arterial Po2 difference (A-aDo2), progressively worsens during exercise at sea-level; this response is further elevated during exercise in hypoxia. Traditionally, pulmonary gas exchange efficiency is assessed through measurements of ventilation and end-tidal gases paired with direct arterial blood gas (ABG) sampling. Because these measures have a number of caveats, particularly invasive blood sampling, the development of new approaches for the noninvasive assessment of pulmonary gas exchange is needed. Is a noninvasive method of assessing pulmonary gas exchange valid during rest and exercise in acute hypoxia? Twenty-five healthy participants (10 female) completed a staged maximal exercise test on a cycle ergometer in a hypoxic chamber (Fio2 = 0.11). Simultaneous ABGs via a radial arterial catheter and noninvasive gas-exchange measurements (AGM100) were obtained in 2-minute intervals. Noninvasive gas exchange, termed the O2 deficit, was calculated from the difference between the end-tidal and the calculated Pao2 (via pulse oximetry and corrected for the Bohr effect by using the end-tidal Pco2). Noninvasive O2 deficit was compared with the traditional alveolar to arterial oxygen difference (A-aDo2), using the traditional Riley analysis. Under conditions of rest at room air, hypoxic rest, and hypoxic exercise, strong correlations between the calculated gPao2 and directly measured Pao2 (R2 = 0.97; P < .001; mean bias = 1.70 mm Hg) were observed. At hypoxic rest and exercise, strong relationships between the estimated and directly measured Pao2 (R2 = 0.68; P < .001; mean bias = 1.01 mm Hg) and O2 deficit with the traditional A-aDo2 (R2 = 0.70; P < .001; mean bias = 5.24 mm Hg) remained. Our findings support the use of a noninvasive measure of gas exchange during acute hypoxic exercise in heathy humans. Further studies are required to determine whether this approach can be used clinically as a tool during normoxic exercise in patients with preexisting impairments in gas exchange efficiency." @default.
• W3019021138 created "2020-05-01" @default.
• W3019021138 creator A5005489723 @default.
• W3019021138 creator A5018677185 @default.
• W3019021138 creator A5059274315 @default.
• W3019021138 creator A5065359883 @default.
• W3019021138 creator A5065805547 @default.
• W3019021138 date "2020-10-01" @default.
• W3019021138 modified "2023-10-10" @default.
• W3019021138 title "Validation of a Noninvasive Assessment of Pulmonary Gas Exchange During Exercise in Hypoxia" @default.
• W3019021138 cites W1586695636 @default.
• W3019021138 cites W1772262635 @default.
• W3019021138 cites W1993290881 @default.
• W3019021138 cites W2015795623 @default.
• W3019021138 cites W2033396053 @default.
• W3019021138 cites W2062115818 @default.
• W3019021138 cites W2064805792 @default.
• W3019021138 cites W2122546182 @default.
• W3019021138 cites W2124589006 @default.
• W3019021138 cites W2131144720 @default.
• W3019021138 cites W2161766609 @default.
• W3019021138 cites W2192145728 @default.
• W3019021138 cites W2215611262 @default.
• W3019021138 cites W2273749813 @default.
• W3019021138 cites W2511883439 @default.
• W3019021138 cites W2758786452 @default.
• W3019021138 cites W2776453592 @default.
• W3019021138 cites W2786957063 @default.
• W3019021138 cites W2794272841 @default.
• W3019021138 cites W2896781077 @default.
• W3019021138 cites W2921781055 @default.
• W3019021138 cites W2969803641 @default.
• W3019021138 doi "https://doi.org/10.1016/j.chest.2020.04.017" @default.
• W3019021138 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32343965" @default.
• W3019021138 hasPublicationYear "2020" @default.
• W3019021138 type Work @default.
• W3019021138 sameAs 3019021138 @default.
• W3019021138 citedByCount "8" @default.
• W3019021138 countsByYear W30190211382020 @default.
• W3019021138 countsByYear W30190211382021 @default.
• W3019021138 countsByYear W30190211382023 @default.
• W3019021138 crossrefType "journal-article" @default.
• W3019021138 hasAuthorship W3019021138A5005489723 @default.
• W3019021138 hasAuthorship W3019021138A5018677185 @default.
• W3019021138 hasAuthorship W3019021138A5059274315 @default.
• W3019021138 hasAuthorship W3019021138A5065359883 @default.
• W3019021138 hasAuthorship W3019021138A5065805547 @default.
• W3019021138 hasBestOaLocation W30190211382 @default.
• W3019021138 hasConcept C116254018 @default.
• W3019021138 hasConcept C126322002 @default.
• W3019021138 hasConcept C164705383 @default.
• W3019021138 hasConcept C178790620 @default.
• W3019021138 hasConcept C185592680 @default.
• W3019021138 hasConcept C2777140959 @default.
• W3019021138 hasConcept C2777953023 @default.
• W3019021138 hasConcept C2779537118 @default.
• W3019021138 hasConcept C2780124106 @default.
• W3019021138 hasConcept C2910590557 @default.
• W3019021138 hasConcept C2988731192 @default.
• W3019021138 hasConcept C42219234 @default.
• W3019021138 hasConcept C540031477 @default.
• W3019021138 hasConcept C71924100 @default.
• W3019021138 hasConcept C7836513 @default.
• W3019021138 hasConcept C84393581 @default.
• W3019021138 hasConceptScore W3019021138C116254018 @default.
• W3019021138 hasConceptScore W3019021138C126322002 @default.
• W3019021138 hasConceptScore W3019021138C164705383 @default.
• W3019021138 hasConceptScore W3019021138C178790620 @default.
• W3019021138 hasConceptScore W3019021138C185592680 @default.
• W3019021138 hasConceptScore W3019021138C2777140959 @default.
• W3019021138 hasConceptScore W3019021138C2777953023 @default.
• W3019021138 hasConceptScore W3019021138C2779537118 @default.
• W3019021138 hasConceptScore W3019021138C2780124106 @default.
• W3019021138 hasConceptScore W3019021138C2910590557 @default.
• W3019021138 hasConceptScore W3019021138C2988731192 @default.
• W3019021138 hasConceptScore W3019021138C42219234 @default.
• W3019021138 hasConceptScore W3019021138C540031477 @default.
• W3019021138 hasConceptScore W3019021138C71924100 @default.
• W3019021138 hasConceptScore W3019021138C7836513 @default.
• W3019021138 hasConceptScore W3019021138C84393581 @default.
• W3019021138 hasFunder F4320320230 @default.
• W3019021138 hasIssue "4" @default.
• W3019021138 hasLocation W30190211381 @default.
• W3019021138 hasLocation W30190211382 @default.
• W3019021138 hasOpenAccess W3019021138 @default.
• W3019021138 hasPrimaryLocation W30190211381 @default.
• W3019021138 hasRelatedWork W1938669439 @default.
• W3019021138 hasRelatedWork W1981955259 @default.
• W3019021138 hasRelatedWork W1993217020 @default.
• W3019021138 hasRelatedWork W2062973780 @default.
• W3019021138 hasRelatedWork W2156715186 @default.
• W3019021138 hasRelatedWork W2417769795 @default.
• W3019021138 hasRelatedWork W2938254392 @default.
• W3019021138 hasRelatedWork W3019021138 @default.
• W3019021138 hasRelatedWork W4206184379 @default.
• W3019021138 hasRelatedWork W60354093 @default.
• W3019021138 hasVolume "158" @default.
• W3019021138 isParatext "false" @default.

• next