Matches in SemOpenAlex for { <https://semopenalex.org/work/W3019067353> ?p ?o ?g. }
- W3019067353 endingPage "442" @default.
- W3019067353 startingPage "423" @default.
- W3019067353 abstract "Abstract Intracellular protein degradation is essential for the survival of all organisms, but its role in interspecies interaction is unknown. Here, we show that the ClpXP protease of Pseudomonas aeruginosa suppresses its antimicrobial activity against Staphylococcus aureus , a common pathogen co‐isolated with P. aeruginosa from polymicrobial human infections. Using proteomic, biochemical, and molecular genetic approaches, we found that this effect is due to the inhibitory effects of ClpXP on the quorum sensing (QS) of P. aeruginosa , mainly by degrading proteins (e.g., PhnA, PhnB, PqsR, and RhlI) which are critical for the production of QS signal molecules PQS and C4‐HSL . We provide evidence that co‐culturing with S. aureus induces a decrease in the activity of ClpXP in P. aeruginosa , an effect which was also achieved by the treatment of P. aeruginosa with N‐acetylglucosamine (GlcNAc), a widespread chemical present on the surface of diverse cell types from bacteria to humans. These findings extend the range of biological events governed by proteolytic machinery to microbial community structure, thus also suggesting that a chemical‐induced alteration of protein homeostasis is a mechanism for interspecies interactions." @default.
- W3019067353 created "2020-05-01" @default.
- W3019067353 creator A5007926032 @default.
- W3019067353 creator A5018791152 @default.
- W3019067353 creator A5025743218 @default.
- W3019067353 creator A5053936942 @default.
- W3019067353 creator A5055519609 @default.
- W3019067353 creator A5061199980 @default.
- W3019067353 creator A5067297930 @default.
- W3019067353 creator A5075423250 @default.
- W3019067353 creator A5080493401 @default.
- W3019067353 creator A5084693085 @default.
- W3019067353 creator A5085370459 @default.
- W3019067353 date "2020-05-08" @default.
- W3019067353 modified "2023-10-14" @default.
- W3019067353 title "Alteration of protein homeostasis mediates the interaction of <i>Pseudomonas aeruginosa</i> with <i>Staphylococcus aureus</i>" @default.
- W3019067353 cites W1512538917 @default.
- W3019067353 cites W1600715779 @default.
- W3019067353 cites W1630001284 @default.
- W3019067353 cites W1749431754 @default.
- W3019067353 cites W1942636041 @default.
- W3019067353 cites W1948277616 @default.
- W3019067353 cites W1972010400 @default.
- W3019067353 cites W1974927036 @default.
- W3019067353 cites W1989889539 @default.
- W3019067353 cites W1997749489 @default.
- W3019067353 cites W2000182306 @default.
- W3019067353 cites W2002319824 @default.
- W3019067353 cites W2003475766 @default.
- W3019067353 cites W2007002493 @default.
- W3019067353 cites W2010542044 @default.
- W3019067353 cites W2012926197 @default.
- W3019067353 cites W2013647096 @default.
- W3019067353 cites W2024471867 @default.
- W3019067353 cites W2026902916 @default.
- W3019067353 cites W2030813162 @default.
- W3019067353 cites W2035782757 @default.
- W3019067353 cites W2036699947 @default.
- W3019067353 cites W2040539560 @default.
- W3019067353 cites W2041350348 @default.
- W3019067353 cites W2054403143 @default.
- W3019067353 cites W2062817953 @default.
- W3019067353 cites W2070925013 @default.
- W3019067353 cites W2076896195 @default.
- W3019067353 cites W2086358238 @default.
- W3019067353 cites W2087491749 @default.
- W3019067353 cites W2089086408 @default.
- W3019067353 cites W2090711340 @default.
- W3019067353 cites W2096008023 @default.
- W3019067353 cites W2098159838 @default.
- W3019067353 cites W2102177890 @default.
- W3019067353 cites W2106884274 @default.
- W3019067353 cites W2107277218 @default.
- W3019067353 cites W2108296508 @default.
- W3019067353 cites W2109545101 @default.
- W3019067353 cites W2112795634 @default.
- W3019067353 cites W2113665955 @default.
- W3019067353 cites W2119158206 @default.
- W3019067353 cites W2129077074 @default.
- W3019067353 cites W2131869707 @default.
- W3019067353 cites W2133093301 @default.
- W3019067353 cites W2135581280 @default.
- W3019067353 cites W2138785360 @default.
- W3019067353 cites W2138999123 @default.
- W3019067353 cites W2140337827 @default.
- W3019067353 cites W2144954424 @default.
- W3019067353 cites W2147898933 @default.
- W3019067353 cites W2148527492 @default.
- W3019067353 cites W2151138933 @default.
- W3019067353 cites W2156731936 @default.
- W3019067353 cites W2162524966 @default.
- W3019067353 cites W2163562422 @default.
- W3019067353 cites W2171974757 @default.
- W3019067353 cites W2193963378 @default.
- W3019067353 cites W2219990459 @default.
- W3019067353 cites W2288575926 @default.
- W3019067353 cites W2314799679 @default.
- W3019067353 cites W2345191754 @default.
- W3019067353 cites W2346143383 @default.
- W3019067353 cites W2401402628 @default.
- W3019067353 cites W2478914105 @default.
- W3019067353 cites W2511941815 @default.
- W3019067353 cites W2529210292 @default.
- W3019067353 cites W2553908226 @default.
- W3019067353 cites W2599504373 @default.
- W3019067353 cites W2704517448 @default.
- W3019067353 cites W2754853133 @default.
- W3019067353 cites W2767921398 @default.
- W3019067353 cites W2773101253 @default.
- W3019067353 cites W2796836297 @default.
- W3019067353 cites W2802064418 @default.
- W3019067353 cites W2804251250 @default.
- W3019067353 cites W2809214793 @default.
- W3019067353 cites W2884958591 @default.
- W3019067353 cites W2885810202 @default.
- W3019067353 cites W2899760200 @default.
- W3019067353 cites W2911732387 @default.
- W3019067353 cites W2912470012 @default.