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- W3019110035 endingPage "200050" @default.
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- W3019110035 abstract "A new series of N'-substituted benzylidene-2-(4-oxo-2-phenyl-1,4-dihydroquinazolin-3(2H)-yl)acetohydrazide ( 5a–5h ) has been synthesized, characterized by FT-IR, NMR spectroscopy and mass spectrometry and tested against human monoamine oxidase (MAO) A and B. Only (4-hydroxy-3-methoxybenzylidene) substituted compounds gave submicromolar inhibition of MAO-A and MAO-B. Changing the phenyl substituent to methyl on the unsaturated quinazoline ring ( 12a–12d ) decreased inhibition, but a less flexible linker ( 14a–14d ) resulted in selective micromolar inhibition of hMAO-B providing insight for ongoing design." @default.
- W3019110035 created "2020-05-01" @default.
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- W3019110035 date "2020-04-01" @default.
- W3019110035 modified "2023-10-02" @default.
- W3019110035 title "Design, synthesis, molecular modelling and<i>in vitro</i>screening of monoamine oxidase inhibitory activities of novel quinazolyl hydrazine derivatives" @default.
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- W3019110035 doi "https://doi.org/10.1098/rsos.200050" @default.
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